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Tegafur

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Identification
Molecular formula
C8H9ClFN3O2
CAS number
17902-23-7
IUPAC name
5-[2-chloroethyl(2-fluoroethyl)amino]-6-methyl-1H-pyrimidine-2,4-dione
State
State

At room temperature, Tegafur exists as a solid.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
420.00
Boiling point (Kelvin)
693.15
General information
Molecular weight
241.69g/mol
Molar mass
241.6870g/mol
Density
1.3800g/cm3
Appearence

Tegafur appears as a white crystalline powder. It is odorless and has a bitter taste.

Comment on solubility

Solubility of 5-[2-chloroethyl(2-fluoroethyl)amino]-6-methyl-1H-pyrimidine-2,4-dione

The solubility of 5-[2-chloroethyl(2-fluoroethyl)amino]-6-methyl-1H-pyrimidine-2,4-dione is an important characteristic that affects its application in various fields. This compound, with its unique molecular structure, exhibits specific solubility traits influenced by several factors:

  • Polarity: Due to the presence of electronegative atoms such as chlorine and fluorine, the compound likely has polar characteristics. This often leads to increased solubility in polar solvents, such as water.
  • Hydrogen Bonding: The functional groups within the compound may allow for hydrogen bonding with solvents, enhancing its solubility profile.
  • Molecular Weight: With a relatively high molecular weight, the solubility may be lower compared to lighter compounds. This is a common trend observed in organic compounds.
  • Temperature Influence: As is the case with many chemicals, solubility may increase with temperature, potentially allowing for greater dissolution rates at elevated temperatures.

In summary, understanding the solubility of 5-[2-chloroethyl(2-fluoroethyl)amino]-6-methyl-1H-pyrimidine-2,4-dione is crucial for its practical applications, particularly in pharmaceutical and biochemical settings. Remarks from previous studies suggest, “solubility characteristics are vital for determining the bioavailability of compounds within biological systems.” Thus, careful consideration of solubility will guide researchers and chemists in effectively utilizing this compound.

Interesting facts

Interesting Facts about 5-[2-chloroethyl(2-fluoroethyl)amino]-6-methyl-1H-pyrimidine-2,4-dione

This compound, often considered in the realm of medicinal chemistry, presents a fascinating case study with its unique structure and potential applications. Here are some interesting aspects:

  • Pharmaceutical Relevance: This compound belongs to a class of pyrimidine derivatives, which are notable for their biological activities, notably in drug design. Compounds like these have been explored for their ability to inhibit specific enzymes or pathways, thus aiding in the treatment of various diseases.
  • Mechanism of Action: As a building block in some therapeutic agents, the presence of both chloro and fluoro substituents can enhance the bioavailability and stability of the compound, making it a prime candidate for further investigation.
  • Importance of Substituents: The addition of different halogen atoms such as chlorine and fluorine can drastically alter a compound's properties. These substitutions may influence solubility, reactivity, and interaction with biological targets, thus playing a crucial role in its function as a drug.
  • Structural Complexity: The complex structure of this compound allows for interesting conformational variations. Studying these variations can provide insight into how the compound interacts with biomolecular sites, which is a vital aspect of drug design and development.
  • Research Potential: Given its structural features, this compound could be a promising candidate for research in areas such as cancer therapy, antimicrobial agents, or other therapeutic avenues. Its synthesis and characterization are significant topics in chemical research.

In conclusion, 5-[2-chloroethyl(2-fluoroethyl)amino]-6-methyl-1H-pyrimidine-2,4-dione has captured the interest of scientists due to its potential applications in drug development and its intriguing structural characteristics. As research continues, this compound may pave the way for new therapeutic agents.

Synonyms
Fluorodopan
Ftordopan
Fluorpan
Fluoropan
Fluorothane
Ftorpan
Fluorodopane
NSC 73754
Ftordopane
O1EXJ975PT
5-((2-Chloroethyl)(2-fluoroethyl)amino)-6-methyluracil
5-((2-Chloroethyl)(2-fluoroethyl)amino)-6-methyl-2,4(1H,3H)-pyrimidinedione
NSC73754
NSC-73754
Uracil, 5-((2-chloroethyl)-(2-fluoroethyl)amino)-6-methyl-
UNII-O1EXJ975PT
2,4(1H,3H)-Pyrimidinedione, 5-((2-chloroethyl)(2-fluoroethyl)amino)-6-methyl-
Uracil, 5-((2-chloroethyl)(2-fluoroethyl)amino)-6-methyl-
DTXSID60232320
Uracil, 5-[(2-chloroethyl)-(2-fluoroethyl)amino]-6-methyl-
5-[(2-Chloroethyl)(2-fluoroethyl)amino]-6-methyl-2,4(1H,3H)-pyrimidinedione
DTXCID60154811
2,4(1H,3H)-Pyrimidinedione, 5-((2-chloroethyl)(2-fluoroethyl)amino)-6-methyl-(9CI)
odacnrqbnvvgai-uhfffaoysa-n
834-91-3
5-[2-chloroethyl(2-fluoroethyl)amino]-6-methyl-1H-pyrimidine-2,4-dione
5-((2-Chloroethyl)(2-fluoroethyl)amino)-6-methylpyrimidine-2,4(1H,3H)-dione
NCIOpen2_003853
CHEMBL450727
SCHEMBL13840898
NCI60_041616
2,3H)-Pyrimidinedione, 5-[(2-chloroethyl)(2-fluoroethyl)amino]-6-methyl-
Uracil, 5-[(2-chloroethyl)-(2-fluoroethyl)amino]-6-methyl-2,4 (1H,3H)-Pyrimidinedione, 5-[(2-chloroethyl)(2-fluoroethyl)amino]-6-methyl-