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Diazepam

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Identification
Molecular formula
C16H13ClN2O
CAS number
439-14-5
IUPAC name
5-[2-(dimethylamino)ethyl]-11-methyl-benzo[b][1,4]benzodiazepin-6-one
State
State

Diazepam is typically at a solid state at room temperature.

Melting point (Celsius)
131.50
Melting point (Kelvin)
404.65
Boiling point (Celsius)
310.00
Boiling point (Kelvin)
583.15
General information
Molecular weight
284.75g/mol
Molar mass
284.7470g/mol
Density
1.3000g/cm3
Appearence

Diazepam commonly appears as a white to light yellow crystalline powder. It is odorless and has a slightly bitter taste.

Comment on solubility

Solubility of 5-[2-(dimethylamino)ethyl]-11-methyl-benzo[b][1,4]benzodiazepin-6-one

The solubility of 5-[2-(dimethylamino)ethyl]-11-methyl-benzo[b][1,4]benzodiazepin-6-one is an important aspect to consider, especially in pharmaceutical applications. Here’s what you should know about its solubility:

  • Solvent Dependency: This compound's solubility can vary significantly depending on the solvent used. Generally, it exhibits better solubility in polar organic solvents.
  • Temperature Influence: Like many organic compounds, its solubility tends to increase with rising temperature, making it more soluble in warm solvents.
  • pH Sensitivity: The solubility may also be affected by the pH of the solution. In certain conditions, ionization can enhance solubility, especially in biological systems.

As a general rule, “solubility is a major contributor to bioavailability,” which is directly relevant for compounds intended for medicinal use. Understanding the solubility profile can guide formulations and effective delivery mechanisms for this compound.

Overall, studying the solubility behavior of 5-[2-(dimethylamino)ethyl]-11-methyl-benzo[b][1,4]benzodiazepin-6-one may provide critical insights into its potential applications and effectiveness in therapeutic settings.

Interesting facts

Interesting Facts about 5-[2-(Dimethylamino)ethyl]-11-methyl-benzo[b][1,4]benzodiazepin-6-one

This intriguing compound belongs to the class of substances known as benzodiazepines, which are widely recognized for their calming effects and use in treating anxiety, insomnia, and other related disorders. Here are some interesting insights of this compound:

  • Structural Complexity: The compound exhibits a fused bicyclic structure, characteristic of benzodiazepines, combining elements of both a benzene and a diazepine ring. This unique architecture contributes to its biological activity.
  • Dimethylamino Group: The presence of a dimethylamino group may enhance its ability to cross the blood-brain barrier, potentially increasing its efficacy as a psychoactive agent.
  • Synthetic Pathways: The development and synthesis of this compound can involve a variety of organic reactions, showcasing intricate chemistry and the skills of synthetic chemists.
  • Research Implications: Benzodiazepines, as a whole, play a critical role in neuroscience and pharmacology, making this compound of interest for further research on its pharmacodynamic and pharmacokinetic properties.
  • Potential Therapeutic Uses: Beyond anxiety and insomnia, research suggests that benzodiazepines may have applications in neurology and psychiatry, aiding in the treatment of seizures and muscle spasms.

As a molecule, 5-[2-(dimethylamino)ethyl]-11-methyl-benzo[b][1,4]benzodiazepin-6-one serves as a noteworthy example of the diverse capabilities and applications of benzodiazepine derivatives. Its structural features and resultant interactions in biological systems invite continued exploration and study.

In the words of renowned chemist Robert H. Grubbs, “The magic of chemistry lies in discovering the beauty of molecular architectures.” Indeed, the complexity of this compound exemplifies that beauty and the vast potential it holds in medicinal chemistry.

Synonyms
Dibenzepin
4498-32-2
Dibenzepine
Dibenzepina
Dibenzepinum
Dibenzepin [INN:BAN]
Dibenzepine [INN-French]
Dibenzepinum [INN-Latin]
Dibenzepina [INN-Spanish]
UNII-510SJZ1Y6L
Dibenzepin (INN)
BRN 0894708
510SJZ1Y6L
DIBENZEPIN [MI]
DIBENZEPIN [INN]
5-[2-(dimethylamino)ethyl]-11-methylbenzo[b][1,4]benzodiazepin-6-one
DIBENZEPIN [WHO-DD]
10-(2-(Dimethylamino)ethyl)-5-methyl-5H-dibenzo(b,e)(1,4)diazepin-11(10H)-one
11H-Dibenzo[b,e][1,4]diazepin-11-one, 10-[2-(dimethylamino)ethyl]-5,10-dihydro-5-methyl-
5,10-Dihydro-10-(2-(dimethylamino)ethyl)-5-methyl-11H-dibenzo(b,e)(1,4)diazepin-11-one
5H-Dibenzo(b,e)(1,4)diazepin-11(10H)-one, 10-(2-(dimethylamino)ethyl)-5-methyl-
DTXSID7022916
11H-Dibenzo(b,e)(1,4)diazepin-11-one, 10-(2-(dimethylamino)ethyl)-5,10-dihydro-5-methyl-
11H-Dibenzo(b,e)(1,4)diazepin-11-one, 5,10-dihydro-10-(2-(dimethylamino)ethyl)-5-methyl-
Ecatril hydrochloride
Dibenzepine (INN-French)
Dibenzepinum (INN-Latin)
Dibenzepina (INN-Spanish)
10-[2-(Dimethylamino)ethyl]-5,10-dihydro-5-methyl-11-H-dibenzo[b,e][1,4]diazepin-11-one
10-[2-(Dimethylamino)ethyl]-5-methyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one
10-(2-(DIMETHYLAMINO)ETHYL)-5,10-DIHYDRO-5-METHYL-11-H-DIBENZO(B,E)(1,4)DIAZEPIN-11-ONE
10-[2-(Dimethylamino)ethyl]-5,10-dihydro-5-methyl-11H-dibenzo[b,e][1,4]diazepin-11-one; Dibenzepin;HF 1927
NSC169412
NCGC00160395-01
SR-05000001528
5-(2-(dimethylamino)ethyl)-11-methylbenzo(b)(1,4)benzodiazepin-6-one
Dibenzepin (free base)
Biomol-NT_000090
Oprea1_703590
SCHEMBL49286
BPBio1_001093
DTXCID702916
CHEMBL1442422
CHEBI:93394
N06AA08
HMS2090H08
EX-A2948
BDBM50101814
AKOS023249382
DB13225
FD21524
NCGC00160395-02
NCGC00160395-03
NS00008457
D07812
AB01275527-01
AB01275527_02
EN300-18563712
Q412107
SR-05000001528-1
BRD-K79145749-001-01-8
BRD-K79145749-003-02-2
5-(2-dimethylaminoethyl)-11-methyl-benzo[b][1,4]benzodiazepin-6-one
5-[2-(dimethylamino)ethyl]-11-methyl-6-benzo[b][1,4]benzodiazepinone
10-[2-(Dimethylamino)ethyl]-5,10-dihydro-5-methyl-11H-dibenzo[b,e][1 ,4]diazepin-11-one;5-Methyl-10b-dimethylaminoethyl-10,11-dihydro -11-oxodibenzo[b,e][1,4]diazepine
10-[2-(Dimethylamino)ethyl]-5-methyl-5,10-dihydro-11H-dibenzo[b,E][1,4]diazepin-11-one #
9-[2-(dimethylamino)ethyl]-2-methyl-2,9-diazatricyclo[9.4.0.0,3,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-10-one