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Clobazam

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Identification
Molecular formula
C16H13ClN2O2
CAS number
22316-47-8
IUPAC name
5-[2-(dimethylamino)ethyl]-11H-benzo[b][1,4]benzodiazepin-6-one
State
State
Clobazam is in a solid state at room temperature, appearing as a crystalline powder which is often used in its solid form for pharmaceutical purposes.
Melting point (Celsius)
178.00
Melting point (Kelvin)
451.00
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.00
General information
Molecular weight
300.74g/mol
Molar mass
300.7440g/mol
Density
1.2129g/cm3
Appearence

Clobazam appears as a white or almost white crystalline powder. It is typically devoid of any significant odor and has a bitter taste.

Comment on solubility

Solubility of 5-[2-(dimethylamino)ethyl]-11H-benzo[b][1,4]benzodiazepin-6-one

The compound 5-[2-(dimethylamino)ethyl]-11H-benzo[b][1,4]benzodiazepin-6-one, represented by the chemical formula C16H13ClN2O2, exhibits interesting solubility characteristics influenced by its chemical structure. Understanding its solubility can help in various applications in pharmacology and medicinal chemistry. Here are several key points regarding its solubility:

  • Solvent Type: The compound tends to be more soluble in organic solvents such as ethanol, methanol, and DMSO (dimethyl sulfoxide), rather than in water.
  • Influence of Functional Groups: The presence of the dimethylamino group can increase solubility in non-polar solvents due to its hydrophobic nature, while the benzodiazepine ring structure may affect solubility profiles.
  • pH Dependency: Solubility can also be pH dependent; in more acidic conditions, certain functional groups might be protonated, enhancing solubility.
  • Temperature Effects: Generally, solubility can increase with temperature, making it crucial to conduct solubility studies at varying temperatures for precise applications.

In conclusion, while 5-[2-(dimethylamino)ethyl]-11H-benzo[b][1,4]benzodiazepin-6-one shows limited water solubility, its solubility characteristics in organic solvents and its dependency on various factors like pH and temperature make it a compound of interest for further research and practical applications.

Interesting facts

Interesting Facts about 5-[2-(dimethylamino)ethyl]-11H-benzo[b][1,4]benzodiazepin-6-one

This compound belongs to the benzodiazepine family, which is renowned for its wide range of psychoactive properties. Benzodiazepines are typically recognized for their effects such as sedation, anxiolysis, and muscle relaxation, making them significant in both medicinal and recreational contexts.

Structure and Properties

The intriguing structure of this compound includes a fused benzodiazepine framework, which enhances its effectiveness. Here are some notable aspects:

  • Functional Groups: The presence of the dimethylamino group is particularly noteworthy, as it contributes to the compound's pharmacology and solubility profile.
  • Pharmacological Interest: Compounds of this nature are often studied for their potential use in treating conditions like anxiety and insomnia.
  • Research Potential: The compound's unique structure presents opportunities for exploration in medicinal chemistry aimed at developing novel anxiolytic and sedative drugs.

Applications and Impacts

As with many benzodiazepines, this compound has implications beyond pure chemistry:

  • Medical Use: It may be investigated as a therapeutic agent, particularly in mental health for combating anxiety disorders.
  • Risks: The compound's classification also brings awareness to the risks of dependency and withdrawal associated with benzodiazepine use.
  • Research Insights: Ongoing studies may provide insights into how modifications to the benzodiazepine framework can yield compounds with improved safety profiles.

In summary, 5-[2-(dimethylamino)ethyl]-11H-benzo[b][1,4]benzodiazepin-6-one is a fascinating compound with rich potential for research. Its unique structure and functional groups provide a crucial basis for studying its effects and applications in various fields, particularly medicine. As research continues, this compound may play an important role in enhancing our understanding of benzodiazepines and their therapeutic possibilities.

Synonyms
Desmethylnoveril
BRN 0892754
5H-DIBENZO(b,e)(1,4)DIAZEPIN-11-ONE, 10,11-DIHYDRO-10-(2-(DIMETHYLAMINO)ETHYL)-
13137-17-2
DTXSID50157013
DTXCID0079504
5-24-04-00111 (beilstein handbook reference)
stbmtrppgsyefd-uhfffaoysa-n
10,11-Dihydro-11-oxo-5H-dibenzo(b,e)(1,4)diazepine, 10-(2-(dimethylamino)ethyl)-
CHEMBL99486
10-[2-(Dimethylamino)ethyl]-5,10-dihydro-11H-dibenzo[b,E][1,4]diazepin-11-one #