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Cloxazolam

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Identification
Molecular formula
C21H23ClN2O2S
CAS number
24168-13-2
IUPAC name
5-[2-(dimethylamino)ethyl]-2-methylsulfanyl-11H-benzo[b][1,4]benzodiazepin-6-one
State
State

At room temperature, cloxazolam is a solid substance. It usually needs to be stored under specific conditions to maintain its stability and efficacy.

Melting point (Celsius)
181.00
Melting point (Kelvin)
454.15
Boiling point (Celsius)
372.00
Boiling point (Kelvin)
645.15
General information
Molecular weight
384.93g/mol
Molar mass
384.4920g/mol
Density
1.1200g/cm3
Appearence

Cloxazolam appears as a solid compound. It is commonly provided in crystalline form and can be seen as a white to off-white powder.

Comment on solubility

Solubility of 5-[2-(dimethylamino)ethyl]-2-methylsulfanyl-11H-benzo[b][1,4]benzodiazepin-6-one

The solubility of 5-[2-(dimethylamino)ethyl]-2-methylsulfanyl-11H-benzo[b][1,4]benzodiazepin-6-one can be considered complex due to the unique structural features of this compound.

Factors affecting the solubility of this compound include:

  • Functional Groups: The presence of dimethylamino and methylsulfanyl groups can enhance interaction with polar solvents.
  • Molecular Structure: The fused benzodiazepine structure may increase hydrophobicity, influencing solubility in nonpolar solvents.
  • Polarity: The overall polarity of the molecule plays a crucial role; more polar compounds tend to be more soluble in polar solvents.

In general, it is suggested that:

  • The compound may exhibit moderate solubility in organic solvents such as ethanol or DMSO.
  • It could be poorly soluble in water due to its aromatic nature and potential hydrophobic characteristics.
  • Using solvents with varying polarity might help achieve better solubility profiles.

As a rule of thumb, "the like dissolves like" principle may apply, meaning that this compound is expected to dissolve better in nonpolar or slightly polar solvents than in highly polar solvents.

Experimental solubility studies are recommended to confirm these theoretical expectations and to guide practical applications.

Interesting facts

Interesting Facts about 5-[2-(dimethylamino)ethyl]-2-methylsulfanyl-11H-benzo[b][1,4]benzodiazepin-6-one

The compound 5-[2-(dimethylamino)ethyl]-2-methylsulfanyl-11H-benzo[b][1,4]benzodiazepin-6-one, commonly referred to in the realm of medicinal chemistry, showcases a fascinating blend of structural complexity and potential pharmacological applications.

Key Characteristics:

  • Structural Significance: This compound belongs to the benzodiazepine family, known for its broad spectrum of biological activities, particularly as anxiolytics and sedatives.
  • Substituted Amine Influence: The dimethylamino group plays a crucial role in enhancing the compound's activity by affecting lipid solubility and receptor affinity.
  • Sulfur-Methyl Group: The presence of the methylsulfanyl group can influence the pharmacokinetics and pharmacodynamics, potentially affecting how the compound interacts within biological systems.

Due to its intricate structure, researchers are investigating this compound's potential in various therapeutic areas. Benzodiazepines are often sought after for their calming effects, but they also carry a risk of dependence when used long-term. As such, research into compounds like this one seeks to balance efficacy with safety.

Potential Applications:

  • Anxiolytic properties that may help in managing anxiety disorders.
  • Potential use in psychiatry to address mood disorders.
  • Exploration of unique receptor interactions that may lead to the development of novel medications.

As we further our understanding of this compound, it exemplifies the importance of innovation in medicinal chemistry. The ongoing investigations into its mechanisms of action could pave the way for breakthroughs in how we approach mental health treatment. The journey from benzo[b][1,4]benzodiazepine to a therapeutic agent highlights the intricate dance of structure, function, and biological relevance.

Synonyms
BRN 0897637
5H-Dibenzo(b,e)(1,4)diazepin-11-one, 10,11-dihydro-10-(2-(dimethylamino)ethyl)-7-methylthio-
1163-28-6
DTXSID20151341
10-(2-(Dimethylamino)ethyl)-7-methylthio-10,11-dihydro-5H-dibenzo(b,e)(1,4)diazepin-11-one
DTXCID9073832
5-25-02-00170 (beilstein handbook reference)