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Diltiazem

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Identification
Molecular formula
C22H26N2O4S
CAS number
42399-41-7
IUPAC name
5-[2-(dimethylamino)ethyl]-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4-one
State
State

At room temperature, Diltiazem is usually found as a solid in the form of a crystalline powder.

Melting point (Celsius)
212.00
Melting point (Kelvin)
485.15
Boiling point (Celsius)
500.00
Boiling point (Kelvin)
773.15
General information
Molecular weight
414.55g/mol
Molar mass
414.5470g/mol
Density
1.2970g/cm3
Appearence

Diltiazem is a white to off-white crystalline powder.

Comment on solubility

Solubility of 5-[2-(dimethylamino)ethyl]-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4-one

The solubility of 5-[2-(dimethylamino)ethyl]-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4-one in various solvents is a vital characteristic influencing its applications and efficacy. Understanding the solubility behavior of this compound can guide scientists and researchers in various fields. Here are some key points regarding its solubility:

  • Polarity: The presence of a dimethylamino group typically increases the polarity of organic compounds, potentially enhancing their solubility in polar solvents.
  • Solvent Interactions: The compound may exhibit different solubility in water, ethanol, and chloroform, depending on the interaction between the solvent and the benzothiazepine structure.
  • Temperature Dependence: Solubility is often temperature-dependent; as temperature increases, solubility in many organic solvents may also increase when determining this compound's practical uses.
  • pH Influence: The solubility might also vary with pH, particularly due to potential protonation of the amino group in acidic conditions, affecting solubility in aqueous environments.

To summarize, evaluating the solubility of 5-[2-(dimethylamino)ethyl]-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4-one requires consideration of its molecular structure and the nature of the solvents involved. Further empirical studies would provide valuable insights into its precise solubility profile.

Interesting facts

Interesting Facts about 5-[2-(dimethylamino)ethyl]-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4-one

This compound, known for its complex structure and unique properties, offers a fascinating insight into the world of organic chemistry and pharmaceuticals. Here are some intriguing aspects of this benzothiazepine derivative:

  • Benzothiazepine Background: Benzothiazepines are a class of compounds recognized for their wide range of biological activities. They often exhibit significant pharmacological effects, which have piqued the interest of researchers.
  • Pharmaceutical Potential: This particular compound structure showcases potential applications in treating conditions such as anxiety and depression, aligning it with the properties of similar psychotropic agents.
  • Dimethylamino Group: The presence of the dimethylamino group is noteworthy as it can enhance the lipophilicity of the compound, which often correlates with increased bioavailability in the body.
  • Research Relevance: Compounds like this are often subjects of research aimed at understanding their mechanism of action, side effects, and interactions with human biological systems.
  • Complex Synthesis: The synthesis of such compounds can be quite challenging, involving multi-step processes that require careful control of reaction conditions.

As a student or scientist, consider the implications of such compounds in medicinal chemistry. Engaging with the material synthesis and biological testing can lead to breakthroughs in understanding how these compounds affect the human body.

Furthermore, the compound’s intricate structure not only highlights the art of organic synthesis but also serves as a reminder of the continual evolution of medicinal compounds in the quest to improve human health. This is a prime example of how scientific exploration can lead to transformative therapies.

Synonyms
Tiazesim
THIAZESIM
Tiazesima
Tiazesime
Tiazesimum
Tiazesim [INN:BAN]
Tiazesime [INN-French]
Tiazesimum [INN-Latin]
Tiazesima [INN-Spanish]
UNII-44G76ZB85O
44G76ZB85O
THIAZESIM [MI]
TIAZESIM [INN]
Tiazesime (INN-French)
Tiazesimum (INN-Latin)
Tiazesima (INN-Spanish)
5-[2-(Dimethylamino)ethyl]-2,3-dihydro-2-phenyl-1,5-benzothiazepin-4(5H)-one
1,5-benzothiazepin-4(5H)-one, 5-(2-Dimethylaminoethyl)-2,3-dihydro-2-phenyl-
5-(2-(DIMETHYLAMINO)ETHYL)-2,3-DIHYDRO-2-PHENYL-1,5-BENZOTHIAZEPIN-4(5H)-ONE
qjjxoefwxsqisu-uhfffaoysa-n
5845-26-1
5-[2-(dimethylamino)ethyl]-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4-one
1,5-Benzothiazepin-4(5H)-one, 5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-phenyl-
5-(2-Dimethylaminoethyl)-2,3-dihydro-2-phenyl-1,5-benzothiazepin-4(5H)-one
1,5-Benzothiazepin-4(5H)-one, 5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-phenyl-
NSC169509
Altinil (*Hydrochloride*)
Oprea1_483346
SCHEMBL49862
CHEMBL2111123
DTXSID30863620
SQ 10496 (*Hydrochloride*)
CHEBI:135391
SQ 10,496 (*Hydrochloride*)
5-(2-dimethylaminoethyl)-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4-one
Q7800304
5-[2-(Dimethylamino)ethyl]-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one #