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Ketazolam

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Identification
Molecular formula
C20H18ClN3O3
CAS number
27229-29-8
IUPAC name
5-[2-(dimethylamino)ethyl]-3-ethylsulfonyl-11-methyl-benzo[b][1,4]benzodiazepin-6-one
State
State

At room temperature, Ketazolam is in a solid state, existing as a crystalline powder.

Melting point (Celsius)
126.00
Melting point (Kelvin)
399.15
Boiling point (Celsius)
502.15
Boiling point (Kelvin)
775.30
General information
Molecular weight
353.45g/mol
Molar mass
353.4540g/mol
Density
1.2800g/cm3
Appearence

Ketazolam typically appears as a white to practically white crystalline powder. It is generally odorless and has a slightly bitter taste.

Comment on solubility

Solubility of 5-[2-(dimethylamino)ethyl]-3-ethylsulfonyl-11-methyl-benzo[b][1,4]benzodiazepin-6-one

The solubility of 5-[2-(dimethylamino)ethyl]-3-ethylsulfonyl-11-methyl-benzo[b][1,4]benzodiazepin-6-one can be a crucial factor in its application, particularly in pharmaceutical formulations. Here are some key points regarding its solubility:

  • Polarity: The presence of polar functional groups, such as the sulfonyl group and the dimethylamino moiety, suggests that the compound may exhibit some degree of solubility in polar solvents, particularly water.
  • Solvent Interactions: Its compatibility with various solvents can widely differ:
    • Commonly, it may dissolve well in organic solvents like ethanol and methanol.
    • Its solubility in non-polar solvents might be limited due to the presence of polar groups.
  • Temperature Effects: As with many compounds, solubility can be temperature-dependent. Increased temperatures often enhance solubility for solids in liquids.

In summary, while the solubility characteristics of this compound lend themselves to being practically useful, empirical testing is essential to accurately determine its solubility in various solvents. As one may quote, "The ability of a compound to dissolve is a reflection of its chemical nature." Understanding these solubility dynamics is fundamental for effective formulation development.

Interesting facts

Interesting Facts about 5-[2-(dimethylamino)ethyl]-3-ethylsulfonyl-11-methyl-benzo[1,4]benzodiazepin-6-one

This compound belongs to the class of benzodiazepines, which are widely recognized for their psychoactive effects. Benzodiazepines are typically used in the treatment of anxiety, insomnia, and seizure disorders. Here, we delve into some interesting aspects of this particular compound:

  • Chemical Structure: The complexity of its structure, consisting of a benzodiazepine core with specific substitutions, enhances its pharmacological properties. The addition of a dimethylaminoethyl group and an ethylsulfonyl moiety plays a crucial role in how the compound interacts with the central nervous system.
  • Mechanism of Action: As with other benzodiazepines, this compound likely exerts its effects by modulating GABAA receptors in the brain, leading to increased inhibitory neurotransmission. This can result in calming effects, muscle relaxation, and potential sedation.
  • Potential Applications: Research indicates that compounds with similar structural frameworks may exhibit promising activity not only as anxiolytics but also as muscle relaxants and anticonvulsants. Therefore, understanding this compound could pave the way for developing new therapeutic agents.
  • Study and Research: Scholars might be particularly interested in investigating the relationship between the compound's structure and its biological activity. Structure-activity relationship (SAR) studies can provide valuable insights into optimizing its efficacy and safety profile.
  • Toxicology and Safety: Like many other benzodiazepine derivatives, safety profiles are essential. Understanding the risks of dependency and side effects is vital as this compound undergoes research, highlighting the need for responsible medication use.

As research continues, the exploration of compounds like 5-[2-(dimethylamino)ethyl]-3-ethylsulfonyl-11-methyl-benzo[1,4]benzodiazepin-6-one can significantly contribute to enhancing mental health therapeutics and our overall understanding of neuropharmacology.

Synonyms
SM-307
22797-20-2
BRN 0722352
11H-Dibenzo(b,e)(1,4)diazepin-11-one, 5,10-dihydro-10-(2-(dimethylamino)ethyl)-8-ethylsulfonyl-5-methyl-
DTXSID90177351
5-25-02-00171 (Beilstein Handbook Reference)
RefChem:236257
DTXCID7099842
5-(2-dimethylaminoethyl)-3-ethylsulfonyl-11-methylbenzo[b][1,4]benzodiazepin-6-one
SCHEMBL29492639