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Medazepam

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Identification
Molecular formula
C16H15ClN2O
CAS number
2898-12-6
IUPAC name
5-[2-(dimethylamino)ethyl]-3-methoxy-11H-benzo[b][1,4]benzodiazepin-6-one
State
State

At room temperature, medazepam is a solid.

Melting point (Celsius)
122.00
Melting point (Kelvin)
395.15
Boiling point (Celsius)
298.00
Boiling point (Kelvin)
571.15
General information
Molecular weight
340.85g/mol
Molar mass
340.4400g/mol
Density
1.2300g/cm3
Appearence

Medazepam is typically found as a crystalline powder. It is often white to slightly creamy in color and is nearly odorless.

Comment on solubility

Solubility of 5-[2-(dimethylamino)ethyl]-3-methoxy-11H-benzo[b][1,4]benzodiazepin-6-one

The solubility of 5-[2-(dimethylamino)ethyl]-3-methoxy-11H-benzo[b][1,4]benzodiazepin-6-one is a significant aspect that impacts its functionality and applications. This compound belongs to a class of pharmaceutical agents, and understanding its solubility profile can reveal much about its behavior in various environments.

Factors Influencing Solubility

  • Molecular Structure: The presence of the dimethylamino group and methoxy group can influence hydrogen bonding and interactions with solvents.
  • Polarity: The overall polarity of the compound generally affects its solubility in polar versus non-polar solvents.
  • pH Dependence: Since the compound contains nitrogen atoms, changes in pH can alter its solubility due to protonation or deprotonation.

As a result of these factors, this compound is expected to have variable solubility:

  • In organic solvents: Likely soluble because of its hydrophobic regions.
  • In water: Solubility may be limited, typical for many similar benzodiazepine derivatives.

In summary, the solubility of 5-[2-(dimethylamino)ethyl]-3-methoxy-11H-benzo[b][1,4]benzodiazepin-6-one is influenced by multiple chemical and environmental factors, making it crucial to consider these variables during formulation and application development. Understanding its solubility can lead to enhanced efficacy and safety in therapeutic use.

Interesting facts

Interesting Facts about 5-[2-(dimethylamino)ethyl]-3-methoxy-11H-benzo[b][1,4]benzodiazepin-6-one

This fascinating compound belongs to the class of benzodiazepines, which are widely recognized for their effectiveness in producing calming effects. Here are some noteworthy points about this unique structure:

  • Pharmacological Potential: Compounds like this one are often explored for their anxiolytic (anti-anxiety), sedative, and muscle relaxant properties. Research into their pharmacological effects can yield valuable insights into mental health treatments.
  • Structural Complexity: The presence of a dimethylamino group showcases the ease with which modifications can alter the biological activity of benzodiazepines, making this compound a subject of interest in medicinal chemistry.
  • Mechanism of Action: Benzodiazepines typically function by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABAA receptor. Understanding how variations in molecular structure affect this mechanism can lead to more targeted therapies with fewer side effects.
  • Research and Development: This compound may provide a foundation for developing new therapeutic agents, especially considering the ongoing need for better treatments for anxiety disorders and insomnia.
  • Historical Relevance: The benzodiazepine family has a rich history, with its discovery changing the landscape of anxiety and sleep disorder treatments in the mid-20th century. Studying derivatives like this compound can help continue that legacy of innovation.

Overall, 5-[2-(dimethylamino)ethyl]-3-methoxy-11H-benzo[b][1,4]benzodiazepin-6-one serves as an intriguing example of the intersection between chemistry and pharmacology, providing endless opportunities for further exploration and understanding.

Synonyms
1668-66-2
BRN 0898208
10,11-Dihydro-11-oxo-5H-dibenzo(b,e)(1,4)diazepine, 10-(2-(dimethylamino)ethyl)-8-methoxy-
5H-Dibenzo(b,e)(1,4)diazepin-11-one, 10,11-dihydro-10-(2-(dimethylamino)ethyl)-8-methoxy-
5-25-02-00170 (beilstein handbook reference)
5-[2-(dimethylamino)ethyl]-3-methoxy-11H-benzo[b][1,4]benzodiazepin-6-one
DTXSID20937243
10,11-Dihydro-10-[2-(dimethylamino)ethyl]-8-methoxy-5H-dibenzo[b,e][1,4]diazepin-11-one
10-[2-(Dimethylamino)ethyl]-8-methoxy-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one