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Clonazepam

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Identification
Molecular formula
C15H10ClN3O3
CAS number
1622-61-3
IUPAC name
5-[2-(dimethylamino)ethyl]-3-methyl-11H-benzo[b][1,4]benzodiazepin-6-one
State
State
Clonazepam is a solid at room temperature. It is often found in a powder form when discussed in chemistry contexts, while in pharmaceutical contexts, it is often in tablet form.
Melting point (Celsius)
239.00
Melting point (Kelvin)
512.15
Boiling point (Celsius)
428.50
Boiling point (Kelvin)
701.65
General information
Molecular weight
315.75g/mol
Molar mass
315.7540g/mol
Density
1.2000g/cm3
Appearence

Clonazepam typically appears as a white, crystalline powder. It is essentially odorless and has a slightly bitter taste. The compound is often prepared in tablet form for pharmaceutical use.

Comment on solubility

Solubility of 5-[2-(dimethylamino)ethyl]-3-methyl-11H-benzo‘[1,4]benzodiazepin-6-one

The solubility of 5-[2-(dimethylamino)ethyl]-3-methyl-11H-benzo‘[1,4]benzodiazepin-6-one can be characterized by several factors. Understanding these aspects is crucial for applications in various fields such as pharmacology and chemical synthesis.

Factors Influencing Solubility

  • Polarity: The presence of the dimethylamino group significantly affects the compound's polarity, which in turn influences its solubility in polar solvents such as water.
  • Temperature: Generally, increasing the temperature enhances solubility, making the compound more soluble in organic solvents at elevated temperatures.
  • pH Levels: The ionization state of the compound can change with pH, affecting its solubility. For example, under acidic conditions, dimethylamino groups can become protonated, potentially increasing solubility in water.

Additionally, it is important to note that:

  • The compound may exhibit varying solubility in different organic solvents including ethanol, methanol, and DMSO.
  • Experimental data suggest that solubility can change with concentration and the presence of other solutes.
  • Formulation conditions are critical when considering usage in pharmaceutical applications.

In conclusion, while specific solubility values may vary, understanding the molecular characteristics and environmental conditions is essential for predicting how 5-[2-(dimethylamino)ethyl]-3-methyl-11H-benzo‘[1,4]benzodiazepin-6-one will behave in solution.

Interesting facts

Interesting Facts about 5-[2-(Dimethylamino)ethyl]-3-methyl-11H-benzo[b][1,4]benzodiazepin-6-one

The compound 5-[2-(dimethylamino)ethyl]-3-methyl-11H-benzo[b][1,4]benzodiazepin-6-one belongs to a class of molecules known as benzodiazepines, which are frequently encountered in medicinal chemistry.

Chemical Class and Functions

Benzodiazepines are renowned for their psychoactive properties, and they offer a variety of therapeutic effects, including:

  • Anxiolytic: Reducing anxiety levels.
  • Hypnotic: Inducing sleep.
  • Muscle Relaxant: Alleviating muscle tension.
  • Anticonvulsant: Preventing seizures.

Structure and Activity

This compound's unique structure allows for:

  • Substitutions at key positions: Variations at the 5- and 2- positions lead to changes in pharmacological activity.
  • Dimethylamino group: This moiety contributes to its neuroactive properties by enhancing lipid solubility, aiding in central nervous system penetration.

Research Insights

Research into this compound has uncovered essential insights, including:

  • Potential for therapeutic application in treating various mental health disorders.
  • Importance in the development of newer drug formulations that minimize dependency and side effects.
  • Role in understanding the mechanisms of action of benzodiazepines on neurotransmitter receptors.

As part of ongoing studies, compounds like this one form the backbone of drug discovery efforts, combining biochemical knowledge with clinical applicability. The implications of such research are vast, potentially leading to innovative treatments for complex conditions.

Synonyms
BRN 0894709
5H-Dibenzo(b,e)(1,4)diazepin-11-one, 10,11-dihydro-10-(2-(dimethylamino)ethyl)-8-methyl-
1668-68-4
DTXSID30168187
5-24-04-00138 (Beilstein Handbook Reference)
10,11-Dihydro-11-oxo-5H-dibenzo(b,e)(1,4)diazepine, 10-(2-(dimethylamino)ethyl)-8-methyl-
DTXCID5090678