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Trazodone

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Identification
Molecular formula
C19H22N4O1
CAS number
19794-93-5
IUPAC name
5-[2-(dimethylamino)ethyl]-8-methoxy-11-methyl-benzo[b][1,4]benzodiazepin-6-one
State
State

At room temperature, trazodone is in a solid state. It is stable under normal conditions and interacts with moisture, which requires it to be stored in a dry environment.

Melting point (Celsius)
87.80
Melting point (Kelvin)
360.80
Boiling point (Celsius)
368.30
Boiling point (Kelvin)
641.30
General information
Molecular weight
371.85g/mol
Molar mass
371.8470g/mol
Density
1.4200g/cm3
Appearence

Trazodone is typically found as a white crystalline powder, which may appear slightly off-white depending on purity. It is usually supplied in tablet form for medical use, appearing as white to off-white tablets, sometimes film-coated.

Comment on solubility

Solubility of 5-[2-(dimethylamino)ethyl]-8-methoxy-11-methyl-benzo[b][1,4]benzodiazepin-6-one

The solubility of 5-[2-(dimethylamino)ethyl]-8-methoxy-11-methyl-benzo[b][1,4]benzodiazepin-6-one can be influenced by several structural properties and environmental factors. Understanding its solubility characteristics is crucial for applications in pharmaceuticals and related fields.

Key Factors Affecting Solubility:

  • Polarity: The presence of a dimethylamino group and a methoxy group suggests a degree of polar character, which may enhance solubility in polar solvents.
  • Hydrogen Bonding: The ability of the compound to form hydrogen bonds can significantly impact its solubility in water and organic solvents.
  • pH Dependence: The ionization state of the compound may vary with pH, affecting its solubility in aqueous solutions, especially if it bears a protonable amine group.
  • Molecular Size: The relatively large and complex structure could result in limited solubility in certain solvents.

This compound is likely to exhibit different solubility profiles in various solvents. As stated, "like dissolves like," so it will show better solubility in solvents with similar polarities. In organic solvents, it may achieve higher solubility due to weak interactions such as Van der Waals forces.

Ultimately, obtaining a precise solubility value requires empirical measurements, as theoretical predictions can only provide a broad understanding of solubility behaviors.

Interesting facts

Interesting Facts about 5-[2-(Dimethylamino)ethyl]-8-methoxy-11-methyl-benzo[b][1,4]benzodiazepin-6-one

This compound, belonging to the benzodiazepine class of drugs, is renowned for its chemical structure which offers intriguing properties and potential therapeutic uses. Here are some noteworthy aspects:

  • Benzodiazepine Family: As part of the benzodiazepine family, this compound exhibits sedative, anxiolytic, and anticonvulsant effects, making it valuable in pharmacology.
  • Dimethylamino Group: The presence of a dimethylamino group contributes to its lipophilicity, enhancing its ability to penetrate the blood-brain barrier, which is crucial for its psychoactive properties.
  • Medicinal Applications: Compounds like this one are often investigated for their potential to manage anxiety disorders, insomnia, and muscle spasms due to their calming effects.
  • Research Interest: This specific compound is an ongoing subject of research; studies frequently focus on optimizing its efficacy and safety profile while minimizing potential side effects such as dependency.
  • Structure-Activity Relationship (SAR): Understanding the SAR of this compound can lead to the development of new derivatives with enhanced therapeutic benefits and reduced risks.

Based on its unique characteristics, scientists are continually exploring the extensive possibilities of this compound and its derivatives in both academic and clinical settings. Whether for medicinal chemistry or drug design, the insights garnered from studying such compounds can pave the way for innovative treatments in mental health and beyond.