Skip to main content

Clotiazepam

ADVERTISEMENT
Identification
Molecular formula
C16H15ClN2O2
CAS number
33671-46-4
IUPAC name
5-[2-(dimethylamino)ethyl]-9-methoxy-11H-benzo[b][1,4]benzodiazepin-6-one
State
State

At room temperature, Clotiazepam is in a solid state. It is a crystalline powder that does not dissolve easily in water.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
780.00
Boiling point (Kelvin)
1 053.15
General information
Molecular weight
353.83g/mol
Molar mass
353.8300g/mol
Density
1.2000g/cm3
Appearence

Clotiazepam is typically encountered as a white or off-white crystalline powder. It is usually without any smell and possesses a slightly bitter taste.

Comment on solubility

Solubility of 5-[2-(dimethylamino)ethyl]-9-methoxy-11H-benzo[b][1,4]benzodiazepin-6-one

The solubility of 5-[2-(dimethylamino)ethyl]-9-methoxy-11H-benzo[b][1,4]benzodiazepin-6-one can be influenced by several factors. Understanding its solubility is crucial for applications in pharmaceutical formulations and other chemical processes.

Key Factors Influencing Solubility:

  • Polarity: The presence of polar functional groups in the structure can enhance solubility in polar solvents, while the hydrophobic regions may promote solubility in non-polar solvents.
  • Temperature: Generally, an increase in temperature can lead to greater solubility for many compounds, as it provides the necessary energy to overcome intermolecular forces.
  • pH Levels: The ionization state of the compound can vary with pH, which may have a significant impact on its solubility, particularly for amine groups like those present in the dimethylamino substituent.
  • Solvent Type: The choice of solvent plays a key role; for example, organic solvents may dissolve this benzo[b][1,4]benzodiazepine more readily than water.

As a representative compound of its class, the solubility of 5-[2-(dimethylamino)ethyl]-9-methoxy-11H-benzo[b][1,4]benzodiazepin-6-one may follow the general trend observed in related benzodiazepines, where:

  • Most benzodiazepines are moderately soluble in organic solvents.
  • Their solubility in water is often limited, necessitating consideration of carriers for effective delivery in pharmaceutical applications.

In conclusion, the solubility of this compound will likely vary across different solvents and conditions, making a clear understanding of these parameters essential for its practical uses.

Interesting facts

Interesting Facts about 5-[2-(dimethylamino)ethyl]-9-methoxy-11H-benzo[b][1,4]benzodiazepin-6-one

This fascinating compound belongs to the class of benzodiazepines, which are well-known for their psychoactive properties. Here are some interesting aspects that highlight its significance:

  • Structural Diversity: The unique structure of this compound features a benzodiazepine core, which is fused with a methoxy group and a dimethylaminoethyl side chain, contributing to its distinctive pharmacological profile.
  • Pharmacological Potential: Compounds of this type have shown promising effects in treating anxiety, insomnia, and seizures, making them essential in the field of medicinal chemistry.
  • Research Applications: Due to its complex structure, this compound serves as a valuable tool in research aimed at understanding the mechanisms of action of benzodiazepines and their effects on the central nervous system.
  • Impact on Drug Development: The structure-activity relationship (SAR) studies of similar compounds have provided insights that aid in the design of new drugs with improved efficacy and safety profiles.
  • Historical Context: The development of benzodiazepines revolutionized the treatment of psychiatric disorders in the mid-20th century, paving the way for further research into alternative compounds that could enhance patient care.

As we continue to explore the captivating world of benzodiazepines, compounds like 5-[2-(dimethylamino)ethyl]-9-methoxy-11H-benzo[b][1,4]benzodiazepin-6-one remind us of the intricate connections between chemistry and pharmacology. Scientists and students alike are encouraged to delve into the structural complexities to uncover new therapeutic possibilities.

Synonyms
BRN 0896434
5H-Dibenzo(b,e)(1,4)diazepin-11-one, 10,11-dihydro-10-(2-(dimethylamino)ethyl)-3-methoxy-
3910-27-8
DTXSID10192349
10,11-Dihydro-11-oxo-5H-dibenzo(b,e)(1,4)diazepine, 10-(2-(dimethylamino)ethyl)-3-methoxy-
DTXCID70114840
5-25-02-00169 (beilstein handbook reference)