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Tadalafil

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Identification
Molecular formula
C22H19N3O4S
CAS number
171596-29-5
IUPAC name
5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonyl-phenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one
State
State

At room temperature, tadalafil is a solid.

Melting point (Celsius)
302.00
Melting point (Kelvin)
575.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
389.40g/mol
Molar mass
389.4040g/mol
Density
1.2315g/cm3
Appearence

Tadalafil is a white to off-white crystalline powder.

Comment on solubility

Solubility Characteristics

The solubility of the compound 5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonyl-phenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one, with the chemical formula C22H19N3O4S, can be influenced by a variety of factors due to its complex structure. This compound features several functional groups that can enhance or hinder its solubility in different solvents.

Factors Influencing Solubility

  • Polarity: The presence of sulfonyl and ether groups can increase polarity, potentially enhancing solubility in polar solvents like water or methanol.
  • Hydrophobic Regions: On the other hand, the propyl and methyl groups are hydrophobic, which may lead to reduced solubility in aqueous environments.
  • Temperature: Solubility may vary with temperature; generally, higher temperatures can increase solubility for many organic compounds.
  • pH Level: The protonation state of the piperazine nitrogen could alter solubility, making it more soluble under acidic conditions.

It's essential to consider these factors when evaluating the solubility of this compound, as they can significantly affect its behavior in both pharmaceutical applications and chemical reactions. In conclusion, understanding the intricate balance of hydrophilic and hydrophobic characteristics is key to accurately predicting the solubility of C22H19N3O4S in various solvents.

Interesting facts

Interesting Facts About 5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonyl-phenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one

This compound is a fascinating example of modern medicinal chemistry, particularly due to its potential therapeutic applications. Here are some interesting points about this unique chemical:

  • Targeted Activity: The structure of this compound suggests it may act on specific biological targets, making it an attractive candidate for the development of novel pharmaceuticals.
  • Sulfonamide Backbone: The presence of a sulfonamide group is notable, as compounds containing this moiety are known for their antiviral and antibacterial properties. This makes them important in the fight against various pathogens.
  • Piperazine Functionality: Incorporating a piperazine ring is a common strategy in medicinal chemistry to enhance pharmacological profiles. It can improve solubility and provide desirable interaction with biological receptors.
  • Versatile Substituents: The ethoxy and methyl groups contribute to the lipophilicity of the molecule, enabling it to cross biological membranes more effectively, which can enhance its efficacy as a drug.
  • Pyrazolo[4,3-d]pyrimidine Framework: This bicyclic structure has been increasingly researched for its variety of biological activities, including anti-inflammatory and anticancer properties. The unique arrangement of nitrogen atoms introduces interesting electronic properties.
  • Research Applications: Compounds like this are often investigated in the realms of oncology and neurology, where their ability to modulate specific pathways could lead to breakthroughs in treatment.

As we continue to explore the myriad of applications for compounds like this one, scientific research remains at the forefront of unlocking their full potential in improving human health. The combination of diverse functional groups and complex ring systems truly makes this a captivating structure in the field of medicinal chemistry!