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Flunitrazepam

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Identification
Molecular formula
C16H12FN3O3
CAS number
1622-62-4
IUPAC name
5-(2-fluorophenyl)-1-methyl-7-nitro-3H-1,4-benzodiazepin-2-one
State
State

At room temperature, Flunitrazepam is typically in a solid state. In its commercial form, it is often found as tablets. These are solid and maintain their form under normal conditions, making them suitable for oral administration.

Melting point (Celsius)
166.00
Melting point (Kelvin)
439.15
Boiling point (Celsius)
514.20
Boiling point (Kelvin)
787.35
General information
Molecular weight
313.27g/mol
Molar mass
313.2740g/mol
Density
1.5550g/cm3
Appearence

Flunitrazepam typically appears as a white to off-white crystalline powder. It is often used in its pill form, which can be white or green depending on the manufacturer and intended use. These pills might have different shapes such as round or oval and are sometimes imprinted with markings for identification purposes. The powder itself is visually similar to other benzodiazepines, presenting no distinct color or texture beyond its crystalline structure.

Comment on solubility

Solubility of 5-(2-fluorophenyl)-1-methyl-7-nitro-3H-1,4-benzodiazepin-2-one

The solubility of 5-(2-fluorophenyl)-1-methyl-7-nitro-3H-1,4-benzodiazepin-2-one (C16H12FN3O3) can be considered through the following aspects:

  • Polarity: This compound exhibits a moderate degree of polarity due to the presence of functional groups, such as the nitro group and fluorine atom. This polarity can affect its interaction with solvents.
  • Solvent Compatibility: The solubility may vary significantly in different solvents:
    • Water: It is generally expected to have low solubility in water due to its hydrophobic aromatic structure.
    • Organic Solvents: The compound may show better solubility in organic solvents such as ethanol or DMSO (dimethyl sulfoxide), which can solvate polar groups effectively.
  • Temperature: Like many chemical compounds, the solubility can be enhanced with an increase in temperature, which can facilitate better dissolution in a given solvent.

Therefore, understanding the solubility characteristics of this compound is crucial for its applications in various chemical and pharmaceutical contexts, especially in formulations where optimal bioavailability is required. As a general remark, “The solubility of a compound is key to unlocking its potential in biomolecular interactions.”

Interesting facts

Interesting Facts about 5-(2-fluorophenyl)-1-methyl-7-nitro-3H-1,4-benzodiazepin-2-one

The compound known as 5-(2-fluorophenyl)-1-methyl-7-nitro-3H-1,4-benzodiazepin-2-one is an intriguing member of the benzodiazepine family, which is well-regarded for its pharmacological significance. Here are some compelling aspects of this compound:

  • Pharmacological Role: This compound exhibits potential activity as a central nervous system depressant, similar to other benzodiazepines. It plays a crucial role in the management of anxiety and seizure disorders.
  • Research Implications: The presence of a fluorine atom, specifically in the 2-position of the phenyl ring, can impact the compound's biological properties, enhancing its potency and selectivity.
  • Synthetic Pathways: The synthesis of this compound can involve multi-step organic reactions, providing a fascinating study of chemical transformations and reaction mechanisms.
  • Chemical Structure: The unique structure of this molecule, characterized by its nitro group, offers diverse interaction capabilities with biological targets, making it a point of interest for medicinal chemists.
  • Potential Applications: Beyond its anticipated medicinal uses, compounds like this are often leveraged in drug design to develop new therapies for neuropsychiatric disorders.
  • Complementary Research: Ongoing studies may involve structural modification of the compound to enhance desired therapeutic effects while reducing side effects.

In conclusion, the exploration of 5-(2-fluorophenyl)-1-methyl-7-nitro-3H-1,4-benzodiazepin-2-one not only deepens our understanding of benzodiazepines but also prompts new inquiries into how slight modifications can lead to substantial changes in a compound's efficacy and safety profile. As Nobel laureate Richard Feynman aptly stated, "What I cannot create, I do not understand," reminding us of the potent interplay between chemistry and biology in drug development.

Synonyms
flunitrazepam
Rohypnol
1622-62-4
Narcozep
Roipnol
Fluninoc
Primun
flunipam
Flunitrazepamum
Fluridrazepam
Flunitrazepamum [INN-Latin]
Silece
Ro 5-4200
flunidazepam
RO-5-4200
[3H]flunitrazepam
Rohypnol (TN)
Flunitrazepam [USAN:INN:BAN:JAN]
2H-1,4-Benzodiazepin-2-one, 5-(2-fluorophenyl)-1,3-dihydro-1-methyl-7-nitro-
5-(o-Fluorophenyl)-1,3-dihydro-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one
Hipnosedon
CCRIS 5287
Flunita
Fluscand
Hypnodorm
Valsera
5-(2-fluorophenyl)-1-methyl-7-nitro-3H-1,4-benzodiazepin-2-one
Hypnor
Primum
RO54200
HSDB 6960
EINECS 216-597-8
Ro-54200
1-Methyl-7-nitro-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2(1H)-one
1,3-Dihydro-5-(o-fluorophenyl)-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one
BRN 0702691
DEA No. 2763
UNII-620X0222FQ
N05CD03
FLUNITRAZEPAM [MI]
620X0222FQ
FLUNITRAZEPAM [INN]
FLUNITRAZEPAM [JAN]
FLUNITRAZEPAM [HSDB]
FLUNITRAZEPAM [USAN]
CHEMBL13280
FLUNITRAZEPAM [MART.]
2H-1,4-BENZODIAZEPIN-2-ONE, 1,3-DIHYDRO-5-(2-FLUOROPHENYL)-1-METHYL-7-NITRO-
FLUNITRAZEPAM [WHO-DD]
DTXSID7023065
CHEBI:31622
5-24-04-00350 (Beilstein Handbook Reference)
FLUNITRAZEPAM [EP MONOGRAPH]
5-(2-Fluorophenyl)-1-methyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one
5-(2-fluorophenyl)-1-methyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazepin-2-one
Flunitrazepamum (INN-Latin)
FLUNITRAZEPAM (MART.)
Flunitrazepan
FLUNITRAZEPAM (EP MONOGRAPH)
5-(2-Fluorophenyl)-1-methyl-7-nitro-1,3-dihydrobenzo[e][1,4]diazepin-2-one
Flunitrazepam (1.0 mg/mL in Methanol)
Flunitrazepam (1.0mg/ml in Acetonitrile)
Roofies
5-(2-Fluorophenyl)-1-methyl-7-nitro-1,3-dihydrobenzo(e)(1,4)diazepin-2-one
[3H]Rohypnol
Flunitrazepamum (Latin)
5-(2-Fluorophenyl)-1-methyl-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one
SCHEMBL44169
MLS003899224
DivK1c_000981
DTXCID103065
GTPL4193
GTPL4360
BDBM25878
HMS503E03
KBio1_000981
NINDS_000981
Flunitrazepam (JP17/USAN/INN)
Flunitrazepam, 1mg/ml in Methanol
LBC44808
UIA53364
NSC708829
Flunitrazepam 0.1 mg/ml in Methanol
Flunitrazepam 1.0 mg/ml in Methanol
AKOS005066009
DB01544
NSC-708829
IDI1_000981
SMR000058981
DB-043520
NS00007996
D01230
Q62947
A810363
Flunitrazepam, European Pharmacopoeia (EP) Reference Standard
Flunitrazepam-13C6, 100 mug/mL in methanol, certified reference material
(E)-5-(2-fluorophenyl)-1-methyl-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one
1,3-dihydro-5-(2-fluorophenyl)-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one
5-(2-Fluorophenyl)-1-methyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one #
216-597-8
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