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Iomeprol

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Identification
Molecular formula
C17H27Cl2N4O4
CAS number
78649-41-9
IUPAC name
5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propyl-pyrimidin-4-amine;chloride;hydrochloride
State
State

At room temperature, Iomeprol is typically found as a solid. This state facilitates its safe handling and storage until it is required for use in imaging procedures where it can be dissolved in solution for injection purposes.

Melting point (Celsius)
0.00
Melting point (Kelvin)
0.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
777.09g/mol
Molar mass
777.0930g/mol
Density
1.4600g/cm3
Appearence

Iomeprol typically appears as a white or almost white powder. It is also available in a stable, crystalline form. The compound is designed to be highly soluble in water, making it suitable for use in various imaging applications.

Comment on solubility

Solubility of 5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propyl-pyrimidin-4-amine;chloride;hydrochloride

The compound 5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propyl-pyrimidin-4-amine;chloride;hydrochloride exhibits noteworthy solubility characteristics, primarily due to the presence of ionic functional groups in its structure. Here are some key points to consider:

  • Water Solubility: The ionic nature of the chloride and hydrochloride forms generally enhances solubility in aqueous environments, making it quite soluble in water.
  • Solubility in Organic Solvents: Depending on the specific interactions between the pyrimidine and pyridine rings, there may be variable solubility in organic solvents, which typically align with polar aprotic solvents.
  • pH Dependence: The solubility of this compound can also be affected by the pH of the solution, as ionization states of the amine group and the surrounding environment play critical roles.
  • Temperature Factors: Like many compounds, increasing temperature may enhance solubility, as kinetic energy allows more efficient interactions between solute and solvent molecules.

In summary, the solubility of this compound is enhanced by its ionic character and structural attributes, making it a fascinating subject for further exploration in various solvents and pH conditions. As always, careful consideration of the surrounding environment is essential when predicting or measuring the solubility of complex chemical compounds.

Interesting facts

Interesting Facts about 5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propyl-pyrimidin-4-amine;chloride;hydrochloride

This compound is notable for its unique structure and potential applications in various fields, particularly in medicinal chemistry. Here are some intriguing aspects:

  • Molecular Structure: The presence of both a pyrimidine and pyridine ring in its structure contributes to its biological activity. Pyridine derivatives are often noted for their ability to interact with biological targets.
  • Quaternary Amine: The compound includes a quaternary amine, indicated by the 1 in its name. This functional group is important as it can influence the compound's solubility and permeability through biological membranes.
  • Potential Medicinal Uses: Due to its distinct chemical characteristics, this compound is being investigated for its role in pharmaceuticals, possibly as an antimicrobial or anticancer agent.
  • Charged State: The inclusion of chloride and hydrochloride forms suggests its ability to exist in charged states, which may enhance its stability and solubility in aqueous environments, making it a candidate for drug formulation.
  • Research Highlight: Recent studies have highlighted the importance of pyridine-based compounds in drug development, making this compound an interesting focal point for ongoing research in synthetic chemistry.

In conclusion, the compound 5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propyl-pyrimidin-4-amine;chloride;hydrochloride stands out due to its intriguing structural elements and promising applications, serving as a great example of the intersection between organic synthesis and medicinal discovery.

Synonyms
Amprolium hydrochloride
137-88-2
Amprolium HCl
amprolium
Amprol
Mepyrium
Thiacoccid
Amprovine
Corid
Amprol 25
Amprolsol vet
Corid vet
Amprol 25 per cent
Corid 20%
Amprolium (hydrochloride)
AMPROCIDUM
1-((4-Amino-2-propylpyrimidin-5-yl)methyl)-2-methylpyridin-1-ium chloride hydrochloride
3053-18-7
EINECS 205-307-5
NSC 523454
NSC-523454
UNII-95CO6N199Q
DTXSID0045547
1-([4-Amino-2-propyl-5-pyrimidinyl]methyl)-2-methylpyridinium chloride
95CO6N199Q
MFCD00078831
Pyridinium, 1-[(4-amino-2-propyl-5-pyrimidinyl)methyl]-2-methyl-, chloride, hydrochloride (1:1:1)
DTXCID8025547
NSC523454
UNII-71M75T660B
NCGC00017020-01
CAS-137-88-2
EINECS 204-458-4
AMPROLIUM (USP-RS)
AMPROLIUM [USP-RS]
AMPROLIUM HYDROCHLORIDE FOR VETERINARY USE
Amprolium (INN-Latin)
Amprolio (INN-Spanish)
AMPROLIUM (USP MONOGRAPH)
AMPROLIUM [USP MONOGRAPH]
5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propylpyrimidin-4-amine;chloride;hydrochloride
DTXSID9048140
NSC 755872
NSC-755872
Cocciprol
CocciAid
AMPROLIUM HYDROCHLORIDE FOR VETERINARY USE (EP MONOGRAPH)
AMPROLIUM HYDROCHLORIDE FOR VETERINARY USE [EP MONOGRAPH]
1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-methylpyridinium chloride monohydrochloride
1-(4-Amino-2-n-propyl-5-pyrimidinylmethyl)-2-methylpyridinium Chloride Hydrochloride
1-[(4-Amino-2-propyl-5-pyrimidinyl)methyl]-2-methylpyridinium chloride monohydrochloride
Amprolium (TN)
PYRIDINIUM, 1-((4-AMINO-2-PROPYL-5-PYRIMIDINYL)METHYL)-2-METHYL-, CHLORIDE, HYDROCHLORIDE (1:1:1)
Prestwick_880
AmproMed for Calves
EINECS 221-272-9
Amprol128
Amprid FOR CALVES
AMPROMED For Cattle
AmproMed P for Poultry
1-[(4-Amino-2-propyl-5-pyrimidinyl)methyl]-2-picolinium chloride monohydrochloride
Hydrochloride, Amprolium
AmproMed-P FOR POULTRY
Amprolium [USP:INN:BAN]
Cocci-Cure C FOR CALVES
Pyridinium, 1-((4-amino-2-propyl-5-pyrimidinyl)methyl)-2-methyl-, chloride, monohydrochloride
Cocci Cure P FOR POULTRY
MLS002154169
SCHEMBL204023
SPECTRUM1500124
Boviprol 9.6% Oral Solution
AMPROLIUM [GREEN BOOK]
amprolium chloride hydrochloride
CORIDType A Medicated Article
Amprolium 9.6% Oral Solution
HY-B0937AR
CHEMBL1318296
DTXCID5028112
HY-B0937A
Amprolium-P 9.6% Oral Solution
PJBQYZZKGNOKNJ-UHFFFAOYSA-M
HMS1568A17
HMS1920E03
Pharmakon1600-01500124
Amprol 25Type A Medicated Article
Tox21_110740
Amprolium (hydrochloride) (Standard)
CCG-39883
NSC755872
s4144
AKOS015951353
Tox21_110740_1
CS-5293
FA32000
Pyridinium, chloride, monohydrochloride
2-Picolinium, 1-((4-amino-2-propyl-5-pyrimidinyl)methyl)-, chloride, hydrochloride
2-Picolinium, 1-((4-amino-2-propyl-5-pyrimidinyl)methyl)-, chloride, monohydrochloride
AMPROLIUM HYDROCHLORIDE [WHO-DD]
NCGC00017020-02
NCGC00017020-03
NCGC00094589-01
NCGC00094589-02
NCGC00263460-01
2-Picolinium, chloride, monohydrochloride
AS-13051
SMR001233467
SY052505
AMPROL 128, Corid 20% Soluble Powder
A2572
NS00079171
SW197002-3
D07571
I10002
AB00053832_02
Amprovine 9.6% Solution, CORID 9.6% Oral Solution
Q27888479
Amprolium hydrochloride, VETRANAL(TM), analytical standard
Amprolium, United States Pharmacopeia (USP) Reference Standard
Amprol 25% Type A Medicated Article, Corid 25% Type A Medicated Article
1-[(4-Amino-2-propyl-5-pyrimidinyl)methyl]-2-methylpyridin-1-ium Chloride Hydrochloride
1-[(4-Amino-2-propyl-5-pyrimidinyl)methyl]-2-methylpyridinium Chloride Hydrochloride
2-Picolinium,1-[(4-amino-2-propyl-5-pyrimidinyl)methyl]-,chloride,hydrochloride
205-307-5