Skip to main content

Niclosamide

ADVERTISEMENT
Identification
Molecular formula
C13H8Cl2N2O4
CAS number
1420-04-8
IUPAC name
5-(2-piperidin-1-ium-1-ylethyl)-3-(2-pyridyl)isoxazole;chloride
State
State
At room temperature, niclosamide is typically found as a solid. It is used in its salt form for pharmaceutical applications.
Melting point (Celsius)
226.00
Melting point (Kelvin)
499.15
Boiling point (Celsius)
665.00
Boiling point (Kelvin)
938.15
General information
Molecular weight
327.13g/mol
Molar mass
327.1300g/mol
Density
1.4120g/cm3
Appearence

Niclosamide appears as a yellowish or pale brown powder. It is practically insoluble in water but soluble in many organic solvents like dimethylformamide. The compound is typically available as a solid and is used in its salt form for various applications.

Comment on solubility

Solubility of 5-(2-piperidin-1-ium-1-ylethyl)-3-(2-pyridyl)isoxazole;chloride

The solubility of 5-(2-piperidin-1-ium-1-ylethyl)-3-(2-pyridyl)isoxazole;chloride is an intriguing topic, particularly due to its unique structural features. This compound is generally expected to exhibit varying solubility characteristics depending on the solvent used:

  • Aqueous Solubility: The presence of the piperidin-ium and chloride functionalities suggests that this compound may have a moderate to high solubility in polar solvents such as water. This is largely due to the ionic nature imparted by the chloride anion and the piperidinium cation.
  • Organic Solvents: In non-polar organic solvents, the solubility may be significantly lower. The hydrophobic nature of the pyridyl and isoxazole groups can act to reduce solubility in a non-polar environment.
  • Temperature Dependence: Solubility can also be influenced by temperature, typically increasing with higher temperatures in most cases, facilitating better dissolving behavior.
  • pH Sensitivity: Given the presence of the piperidin-ium group, solubility may be pH-dependent. In more alkaline conditions, the compound might experience changes in solubility due to deprotonation and the resultant ionic forms.

Overall, when considering the solubility profile, it's critical to assess both the solvent characteristics and the environmental conditions, as these factors play a significant role in determining how well this compound will dissolve. As such, various experiments can yield interesting insights into these solubility dynamics.

Interesting facts

Interesting Facts about 5-(2-piperidin-1-ium-1-ylethyl)-3-(2-pyridyl)isoxazole;chloride

The compound 5-(2-piperidin-1-ium-1-ylethyl)-3-(2-pyridyl)isoxazole;chloride is a fascinating example within the realm of pharmaceutical chemistry. Here are some intriguing insights regarding this compound:

  • Versatile Structural Components: This compound incorporates multiple functional groups, including a piperidine moiety and a pyridine ring, both of which are known for their roles in biological activity. The fusion of these structures can lead to compounds that exhibit a variety of pharmacological properties.
  • Isoxazole Ring: The isoxazole moiety is particularly interesting due to its presence in many biologically active compounds, such as anti-inflammatory and antitumor agents. The unique nitrogen-oxygen arrangement offers potential for diverse interactions in biological systems.
  • Quaternary Amines: The inclusion of a piperidin-1-ium part indicates that the compound is a quaternary ammonium salt. This property can enhance solubility and compatibility with biological membranes, making the compound more effective in reaching targets within living organisms.
  • Potential Applications: Due to its structural characteristics, this compound may be of significant interest in drug development. Researchers often explore similar structures for their effectiveness as neurotransmitter modulators, particularly in areas related to cognitive function.
  • Research Importance: Given the current focus on developing new therapeutic agents, compounds like 5-(2-piperidin-1-ium-1-ylethyl)-3-(2-pyridyl)isoxazole;chloride provide exciting possibilities for novel treatments in medicine.

In conclusion, the synthesis and study of this compound open up numerous avenues for scientific exploration and potentially lead to the discovery of effective medicinal agents. As with many compounds in the field, the intricate balance of structure and function is key to unlocking its properties.

Synonyms
3-(2-Pyridyl)-5-(2-piperidinoethyl)-isoxazole hydrochloride
2148-68-7
ISOXAZOLE, 5-(2-PIPERIDINOETHYL)-3-(2-PYRIDYL)-, HYDROCHLORIDE