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Berberine chloride

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Identification
Molecular formula
C20H18ClNO4
CAS number
1414337-48-4
IUPAC name
5-(2,2-dimethylpropyl)-7-methyl-[1,3]dioxolo[4,5-g]isoquinolin-6-ium;chloride
State
State

At room temperature, berberine chloride is typically in a solid state. It needs to be stored away from moisture, as it can absorb water from the surroundings leading to a clumpy appearance.

Melting point (Celsius)
145.00
Melting point (Kelvin)
418.15
Boiling point (Celsius)
260.00
Boiling point (Kelvin)
533.15
General information
Molecular weight
336.36g/mol
Molar mass
372.8710g/mol
Density
1.4102g/cm3
Appearence

Berberine chloride appears as a yellow crystalline powder. It is sensitive to light and variations in pH, which can lead to color changes. The crystalline structure is well-defined, and it usually appears as a solid at room temperature.

Comment on solubility

Solubility of 5-(2,2-dimethylpropyl)-7-methyl-[1,3]dioxolo[4,5-g]isoquinolin-6-ium;chloride

The solubility of 5-(2,2-dimethylpropyl)-7-methyl-[1,3]dioxolo[4,5-g]isoquinolin-6-ium chloride exhibits unique characteristics, largely influenced by its ionic nature. As a quaternary ammonium compound, its solubility can be discussed as follows:

  • Solvent interactions: This compound is typically soluble in polar solvents, such as water and methanol, due to the presence of ionic interactions.
  • Hydration shell: The chloride ion plays a significant role in promoting solubility, as it can form a hydration shell around the cation, aiding in dissolution.
  • Temperature effect: Like many ionic compounds, an increase in temperature can enhance solubility, allowing greater interaction between solute and solvent.
  • pH influence: The solubility may be influenced by the pH of the solution; in more acidic or basic conditions, different forms of the compound may emerge, potentially affecting its dissolution properties.

In summary, while the solubility of this compound can be considered favorable in polar solvents, the exact conditions (temperature, pH) can have a notable impact on the overall solubility profile and behavior in solution.

Interesting facts

Exploring 5-(2,2-dimethylpropyl)-7-methyl-[1,3]dioxolo[4,5-g]isoquinolin-6-ium;chloride

This compound, a member of the isoquinoline family, displays a rich blend of structure and functionality that makes it particularly interesting for chemists. Here are some notable points:

  • Diverse Applications: Isoquinolines, like this one, are known for their roles in medicinal chemistry. They can act as potential candidates for the development of pharmaceuticals.
  • Unique Structure: The presence of a dioxole group in the compound adds to its complexity, providing opportunities for unique reactivity and interaction with biological systems.
  • Stability and Reactivity: The charged nature of the isoquinolinium part of the compound suggests interesting electrochemical properties, which can be exploited in various chemical reactions.
  • Biological Interest: Compounds with similar structures have been researched for their anticancer, antibacterial, and anti-inflammatory properties, making them crucial in drug design.
  • Environmental Relevance: With growing concerns over synthetic organic compounds, understanding how such compounds behave in biological and environmental systems becomes paramount for safety assessments.

As noted by researchers, "The isoquinoline scaffold provides a versatile platform for diverse structural modifications, inviting ongoing chemical exploration." This emphasizes the continual evolution of compound applications in science. The potential for innovative findings in fields ranging from pharmacology to materials science makes this compound a fascinating area of study.

In summary, 5-(2,2-dimethylpropyl)-7-methyl-[1,3]dioxolo[4,5-g]isoquinolin-6-ium;chloride not only poses intriguing theoretical questions but also offers practical pathways towards meaningful scientific advancements. The intersection of chemistry with biology and pharmacology surrounding this compound is a testament to the lasting impact of isoquinoline derivatives in modern science.

Synonyms
17105-28-1
1-Neopentyl-3-methyl-6,7-methylenedioxyisoquinoline hydrochloride
7-Methyl-5-neopentyl-1,3-dioxolo(4,5-g)isoquinoline hydrochloride
1,3-DIOXOLO(4,5-g)ISOQUINOLINE, 7-METHYL-5-NEOPENTYL-, HYDROCHLORIDE