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Pravastatin

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Identification
Molecular formula
C23H36O7
CAS number
81093-37-0
IUPAC name
5-[(2S,4R,5R,6R,7R,11S,14S,16R)-5,14-dihydroxy-7,11-dimethyl-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadecan-6-yl]pyran-2-one
State
State

At room temperature, Pravastatin is a solid. Given its typical pharmaceutical preparation, it is commonly encountered as a powder or in tablet form as its sodium salt for ease of dissolution and bioavailability.

Melting point (Celsius)
169.00
Melting point (Kelvin)
442.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
424.54g/mol
Molar mass
424.5390g/mol
Density
1.1550g/cm3
Appearence

Pravastatin is typically a white to off-white crystalline powder. It is known for its amorphous appearance and is hygroscopic in nature. The compound is often obtained as sodium salt for pharmaceutical uses.

Comment on solubility

Solubility of 5-[(2S,4R,5R,6R,7R,11S,14S,16R)-5,14-dihydroxy-7,11-dimethyl-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadecan-6-yl]pyran-2-one

The solubility of this complex chemical compound demonstrates several intriguing characteristics that can be summarized as follows:

  • Solvent Polarity: The solubility of organic compounds often depends on the polarity of the solvent. Non-polar solvents, such as hexane, typically cannot dissolve polar compounds, whereas polar solvents like water are capable of dissolving ionic and other polar substances.
  • Hydroxy Groups Influence: The presence of multiple hydroxy groups in this compound enhances its potential solubility in polar solvents, due to hydrogen bonding interactions that facilitate better dissolution.
  • Hydrophobic Regions: The hydrophobic portions of the molecule may hinder solubility in aqueous solutions, depending on their size and structure. This balancing act between hydrophilicity and hydrophobicity plays a critical role in determining solubility.
  • Concentration Effects: As with many organic compounds, solubility can be affected by concentration. At higher concentrations, solubility may plateau, leading to precipitation if saturation is reached.
  • Temperature Dependence: Temperature can also influence solubility; generally, the solubility of solids in liquids increases with temperature, while gases tend to be less soluble at elevated temperatures.

In summary, understanding the solubility of 5-[(2S,4R,5R,6R,7R,11S,14S,16R)-5,14-dihydroxy-7,11-dimethyl-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadecan-6-yl]pyran-2-one requires careful consideration of its structural features and the surrounding environment, making it a compelling subject for further exploration in the field of chemistry.

Interesting facts

Interesting Facts about 5-[(2S,4R,5R,6R,7R,11S,14S,16R)-5,14-dihydroxy-7,11-dimethyl-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadecan-6-yl]pyran-2-one

This compound is a fascinating example of complex organic chemistry, showcasing the intricate structure and chemical functionalities that can arise from natural products. Here are some intriguing aspects of this compound:

  • Natural Product Origin: Compounds like this one often derive from natural sources, specifically from plants or microbial metabolites. They may play significant roles in biological processes.
  • Stereochemistry: The stereochemical configuration of this compound is notably complex, featuring multiple chiral centers. This intricacy implies that even slight modifications in its structure could lead to entirely different properties and biological activities.
  • Potential Applications: Due to its structure, this chemical has potential applications in pharmaceuticals, especially in the development of new drugs that target specific diseases or conditions, particularly those related to metabolic or endocrine functions.
  • Biological Activity: Many compounds with similar structures exhibit a range of biological activities, including antimicrobial, anti-inflammatory, and anticancer properties. Research into this compound might unveil new therapeutic avenues.
  • Research and Development: Ongoing research might explore the synthesis and modification of this compound to enhance its effectiveness and reduce possible side effects, demonstrating the importance of chemical innovation.

In the world of medicinal chemistry, understanding the structure-activity relationship of such complex molecules is crucial for designing novel therapeutics. It emphasizes the beauty of chemistry, where intricacy meets functionality.

Synonyms
Deacetylcinobufagin
NSC 234203
5-beta-BUFA-20,22-DIENOLIDE, 3-beta,16-beta-DIHYDROXY-14,15-beta-EPOXY-
5beta-Bufa-20,22-dienolide, 14,15beta-epoxy-3beta,16beta-dihydroxy-
Bufa-20,22-dienolide, 14,15-epoxy-3,16-dihydroxy-, (3beta,5beta,15beta,16beta)-