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Iodixanol

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Identification
Molecular formula
C35H44I6N6O15
CAS number
92339-11-2
IUPAC name
5-[[3-[3,5-bis[[2,3-dihydroxy-1-(hydroxymethyl)propyl]carbamoyl]-2,4,6-triiodo-N-methyl-anilino]-3-oxo-propanoyl]-methyl-amino]-N1,N3-bis[2,3-dihydroxy-1-(hydroxymethyl)propyl]-2,4,6-triiodo-benzene-1,3-dicarboxamide
State
State

Iodixanol is solid at room temperature; however, it is commonly used in a liquid form when dissolved in water or other solvents for applications such as contrast media in medical imaging.

Melting point (Celsius)
162.00
Melting point (Kelvin)
435.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
1550.24g/mol
Molar mass
1 550.2410g/mol
Density
1.6350g/cm3
Appearence

Iodixanol appears as a white crystalline powder. When prepared as a solution for medical imaging, it is clear, colorless to pale yellow in color.

Comment on solubility

Solubility of 5-[[3-[3,5-bis[[2,3-dihydroxy-1-(hydroxymethyl)propyl]carbamoyl]-2,4,6-triiodo-N-methyl-anilino]-3-oxo-propanoyl]-methyl-amino]-N1,N3-bis[2,3-dihydroxy-1-(hydroxymethyl)propyl]-2,4,6-triiodo-benzene-1,3-dicarboxamide

The solubility of the compound with the formula C35H44I6N6O15 presents an intriguing scenario due to its complex structure and the presence of multiple functional groups. Understanding its solubility can be approached through several key factors:

  • Hydrophilicity vs. Hydrophobicity: The numerous hydroxyl (-OH) groups suggest a degree of hydrophilicity, promoting solubility in polar solvents such as water.
  • Presence of Iodine: The six iodine atoms in the structure can impart significant hydrophobic characteristics, potentially reducing overall solubility in aqueous solutions.
  • Interactions with Solvents: The specific interactions between the compound and solvents can determine solubility. Polar non-protic solvents may enhance solubility due to favorable hydrogen bonding.
  • Temperature Influence: Solubility tends to increase with temperature in many compounds; however, the unique structure of this molecule may lead to variable outcomes.

In summary, the solubility of this compound can be influenced by:

  1. **Functional groups present** - multifunctional nature may enhance solubility in specific solvents.
  2. **Molecular weight** - higher weights may hinder solubility.
  3. **Intermolecular forces** - the balance between dispersive forces and polar interactions play a crucial role.

In practical terms, this compound may demonstrate moderate solubility in aqueous environments, and further experimentation would be necessary to quantify this aspect accurately.

Interesting facts

Interesting Facts about 5-[[3-[3,5-bis[[2,3-dihydroxy-1-(hydroxymethyl)propyl]carbamoyl]-2,4,6-triiodo-N-methyl-anilino]-3-oxo-propanoyl]-methyl-amino]-N1,N3-bis[2,3-dihydroxy-1-(hydroxymethyl)propyl]-2,4,6-triiodo-benzene-1,3-dicarboxamide

This fascinating compound, often referred to in the literature as a form of targeted agent, is particularly significant due to its intricate structure and potential applications in medicinal chemistry.

Key Features

  • Complexity: The compound boasts a highly complex molecular framework, which includes multiple functional groups that enhance its biological activity.
  • Iodine Content: With three iodine atoms incorporated into its structure, this compound showcases the importance of halogenated groups in enhancing therapeutic efficacy and imaging capabilities.
  • Biocompatibility: The presence of multiple hydroxyl groups suggests a degree of biocompatibility, potentially allowing for interactions with biological molecules.
  • Applications: This compound could be studied for its potential role in improving targeting in drug delivery systems, particularly in cancer therapy, where precision is crucial.

Potential Benefits

Researchers are excited about compounds with such multifunctionality because they can:

  • Enable targeted therapies with reduced side effects compared to traditional chemotherapies.
  • Facilitate the development of imaging agents that can improve visualization of tumors.
  • Be modified to enhance their efficacy based on the specific biological pathways of interest.

Conclusion

This compound serves as an excellent example of how chemical modifications can lead to innovative solutions in biomedical applications. As scientists continue to explore its properties and mechanisms, new avenues for utilizing its unique characteristics will likely emerge, paving the way for advances in both research and therapeutic approaches.

Synonyms
iotrolan
Iotrol
79770-24-4
Isovist
Iotrovist
Osmovist
Osmovist 190
Osmovist 240
Iotrolanum
Iotrolum
Isovist 300
DL-3117
Iotrolanum [Latin]
Iotrolum [INN-Latin]
DL 3-117
SH 437
UNII-16FL47B687
ZK 39482
ZK 39 482
Compound ZK 39482
1,3-Benzenedicarboxamide, 5,5'-((1,3-dioxo-1,3-propanediyl)bis(methylimino))bis(N,N'-bis(2,3-dihydroxy-1-(hydroxymethyl)propyl)-2,4,6-triiodo-
16FL47B687
ZK-39482
ZK-39-482
2,4,6-triiodo-5-[methyl-[3-oxo-3-[2,4,6-triiodo-N-methyl-3,5-bis(1,3,4-trihydroxybutan-2-ylcarbamoyl)anilino]propanoyl]amino]-1-N,3-N-bis(1,3,4-trihydroxybutan-2-yl)benzene-1,3-dicarboxamide
5,5'-(Malonylbis(methylimino))bis(N,N'-bis(2,3-dihydroxy-1-(hydroxymethyl)propyl)-2,4,6-triiodoisophthalamide)
DTXSID0023165
Iotrolanum (Latin)
Iotrolum (INN-Latin)
IOTROLAN (MART.)
IOTROLAN [MART.]
IOTROLAN (EP MONOGRAPH)
IOTROLAN [EP MONOGRAPH]
Iotrolan [USAN:INN:BAN:JAN]
IOTROLAN [USAN]
IOTROLAN [INN]
IOTROLAN [JAN]
IOTROLAN [MI]
IOTROLAN [VANDF]
Isovist 300 (TN)
IOTROLAN [WHO-DD]
SCHEMBL25535
Iotrolan (JAN/USAN/INN)
IOTROLAN [ORANGE BOOK]
Iotrolan for system suitability
DTXCID303165
CHEMBL1200555
CHEBI:31715
SH-L-437D
V08AB06
DB09487
1,3-Benzenedicarboxamide, 5,5'-((1,3-dioxo-1,3-propanediyl)bis(methylimino))bis(N,N'-bis(2,3-dihydroxy-1-(hydroxymethyl)propyl))-2,4,6-triiodo-
DA-54358
HY-107992
CS-0031118
NS00005779
D01714
EN300-19767814
Q6064149
2,4,6-triiodo-5-{N-methyl-2-[methyl({2,4,6-triiodo-3,5-bis[(1,3,4-trihydroxybutan-2-yl)carbamoyl]phenyl})carbamoyl]acetamido}-N1,N3-bis(1,3,4-trihydroxybutan-2-yl)benzene-1,3-dicarboxamide
5,5'-[(1,3-dioxopropane-1,3-diyl)bis(methylimino)]bis{N,N'-bis[2,3-dihydroxy-1-(hydroxymethyl)propyl]-2,4,6-triiodobenzene-1,3-dicarboxamide}