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NADPH

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Identification
Molecular formula
C21H30N7O17P3
CAS number
53-57-6
IUPAC name
[[5-(3-acetylpyridin-1-ium-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] [5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl hydrogen phosphate
State
State

At room temperature, NADPH is generally in a solid state and can be dehydrated to yield a powder form. It is hygroscopic and may absorb moisture from the air.

Melting point (Celsius)
184.00
Melting point (Kelvin)
457.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
273.15
General information
Molecular weight
745.42g/mol
Molar mass
745.4210g/mol
Density
1.2610g/cm3
Appearence

NADPH, or Nicotinamide adenine dinucleotide phosphate, appears as a fine white to off-white crystalline powder. It is often available in its sodium salt form, which shares this appearance.

Comment on solubility

Solubility of the Compound

The solubility of the compound C21H30N7O17P3 is a critical aspect that can influence its application in various fields. Understanding the solubility characteristics can provide valuable insights into its behavior in different environments.


Factors Affecting Solubility

  • Polarity: The presence of multiple functional groups such as hydroxy and phosphoryl may enhance the compound's solubility in polar solvents like water.
  • Hydrogen Bonding: The ability to form hydrogen bonds with solvent molecules can significantly increase solubility. In this compound, the hydroxyl groups can act as hydrogen bond donors or acceptors.
  • Molecular Interactions: The structure includes aromatic components, which can interact differently with various solvents, potentially affecting solubility.

Given these factors, it is hypothesized that the compound is likely to exhibit moderately high solubility in polar solvents while demonstrating reduced solubility in non-polar solvents. Further experimental data would be vital to quantify these solubility characteristics accurately. As stated in chemical literature, "Understanding solubility is paramount as it influences not only the bioavailability of pharmaceutical compounds but also their stability and effectiveness."

Interesting facts

Interesting Facts about [5-(3-acetylpyridin-1-ium-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] [5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl hydrogen phosphate

This complex compound is a fascinating example of how chemical structures can convey multiple functions in biochemical applications. The compound features a unique combination of pyridine and purine derivatives, which are known for their roles in biological systems, including nucleic acid and energy metabolism.

  • Versatile Applications: The structural components of this compound suggest potential applications in medicinal chemistry, particularly as a drug precursor or a biochemical probe.
  • Enzymatic Interactions: The dihydroxy-tetrahydrofuran portion is likely to facilitate interactions with various enzymes, such as kinases and phosphatases, playing a crucial role in cellular signaling.
  • Phosphate Group Diversity: The presence of the hydrogen phosphate group indicates that this compound can participate in energy transfer processes similar to ATP, thus hinting at its potential involvement in metabolic pathways.

Moreover, the presence of multiple functional groups enhances the compound's ability to engage in hydrogen bonding, which is vital for its solubility in biological media and its interactions with biomolecules. As noted by many researchers, compounds like this demonstrate how the intricate design of a molecule can lead to diverse biological activities.

Overall, the compound's structural complexity not only makes it an interesting subject for study in organic chemistry but also reflects its potential significance in life sciences. As such, further research into its properties could unveil more exciting applications in drug design and therapeutic interventions.

Synonyms
AcPyAD
3-Acetylpyridine diphosphopyridine nucleotide
KPVQNXLUPNWQHM-UHFFFAOYSA-O
DPN, 3-acetyl pyridine derivative
NSC20275
NSC-20275
Acetyl-3-pyridine adenine dinucleotide
3-acetyl-1-(5-{[({[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy(hydroxy)phosphoryl)oxy]methyl}-3,4-dihydroxyoxolan-2-yl)-1??-pyridin-1-ylium