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NAD+

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Identification
Molecular formula
C21H27N7O14P2
CAS number
53-84-9
IUPAC name
[5-(3-acetylpyridin-1-ium-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl [[5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphate
State
State

At room temperature, NAD+ typically exists as a solid in the form of sodium salt. The compound is moderately soluble in water owing to the polar nature of its sugar and phosphate groups.

Melting point (Celsius)
160.00
Melting point (Kelvin)
433.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
663.43g/mol
Molar mass
663.4250g/mol
Density
1.3677g/cm3
Appearence

NAD, or Nicotinamide adenine dinucleotide, is often encountered as a white amorphous powder when isolated in pure form. It can also appear as a crystalline powder depending on the method of preparation and its hydration state.

Comment on solubility

Solubility Characteristics

The compound [5-(3-acetylpyridin-1-ium-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl [[5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphate, with the chemical formula C21H27N7O14P2, exhibits interesting solubility properties influenced by its complex structure.

Solubility in Different Solvents

This compound's solubility can vary widely depending on the solvent used. Here are some key points to consider:

  • Aqueous Solubility: Due to its phosphoryl and hydroxyl groups, this compound tends to be soluble in water, especially in its protonated form.
  • Polar Solvents: Solvents like methanol and ethanol may enhance solubility due to polar interactions.
  • Non-Polar Solvents: The hydrophobic regions may limit solubility in organic solvents like hexane or chloroform.

Factors Influencing Solubility

The solubility of this compound can be affected by several factors:

  • pH Level: Altering the pH can change the protonation state of the nitrogen atoms, impacting solubility.
  • Temperature: Increased temperature often enhances solubility due to greater kinetic energy.
  • Concentration: At higher concentrations, the solubility may decrease due to saturation effects.

In conclusion, the solubility of the compound [5-(3-acetylpyridin-1-ium-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl [[5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphate is a prime example of how the interplay of chemical structure, solvent properties, and external conditions can create a complex solubility profile. Understanding these factors is essential for applications involving this compound.

Interesting facts

Interesting Facts about [5-(3-acetylpyridin-1-ium-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl [[5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphate

This complex compound is a fascinating example of interdisciplinary chemistry, bridging organic, medicinal, and biochemical domains. Below are some interesting aspects:

  • Structural Complexity: The molecule features a unique intertwining of pyridine, purine, and tetrahydrofuran moieties, showcasing the versatility of organic structures in biological systems.
  • Biological Significance: Compounds like this are often investigated for their potential in drug development. The presence of phosphoryl groups suggests possible roles in signaling pathways and enzyme activity regulation.
  • Pyridinium Ion: The incorporation of a pyridinium ion grants the compound enhanced solubility in biological media, making it a prime candidate for pharmacological applications.
  • Potential Applications: The design of such molecules is integral in the study of nucleic acids and the development of therapeutics aimed at genetic diseases, as they may influence RNA and DNA interactions.

As one researcher once said, "The beauty of chemistry lies in the intricate connections established through molecular design." This compound exemplifies that beauty through its sophisticated architecture and potential functional implications in biological research.

Exploring such compounds not only expands our understanding of molecular interactions but also paves the way for innovative treatments and interventions in medicine. Overall, the exploration of compounds like this is a thrilling journey into the unknown, with countless possibilities waiting to be discovered.

Synonyms
[5-(3-acetylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl [[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphate
PD040308
3-acetyl-1-[(2R,3R,4S,5R)-5-{[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl phosphonato)oxy]methyl}-3,4-dihydroxyoxolan-2-yl]-1lambda-pyridin-1-ylium