NADP+ | Solubility of Things

Identification

Molecular formula

C₂₁H₂₉N₇O₁₇P₃

CAS number

53-59-8

IUPAC name

[[5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] [3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)tetrahydrofuran-2-yl]methyl hydrogen phosphate

State

At room temperature, NADP⁺ would be a solid in its pure, dry form, but it is typically handled in solution in biological settings.

Melting point (Celsius)

140.00

Melting point (Kelvin)

413.15

Boiling point (Celsius)

351.59

Boiling point (Kelvin)

624.74

General information

Molecular weight

743.41g/mol

Molar mass

743.4050g/mol

Density

0.1283g/cm³

Appearence

NADP⁺ is typically found in aqueous solutions as it is a coenzyme used in redox reactions. In its solid form (as a powder), it would appear as a white to off-white crystalline powder.

Comment on solubility

Solubility of [5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] [3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)tetrahydrofuran-2-yl]methyl hydrogen phosphate

The solubility of the compound C₂₁H₂₉N₇O₁₇P₃ is a complex issue, often influenced by various factors. Here are some key points to consider:

Polarity: This compound contains both polar functional groups, such as hydroxyls (-OH) and a phosphate group (-PO₄), which can lead to strong interactions with water, enhancing its solubility in polar solvents.
Hydrogen Bonding: The presence of multiple hydroxyl groups suggests a high potential for hydrogen bonding, which may aid solubility in water-based solutions.
Hydrophilicity vs. Hydrophobicity: The balance between hydrophilic (water-attracting) and hydrophobic (water-repelling) characteristics plays a crucial role. The hydrophilic components are likely to make the compound soluble in polar solvents, while any hydrophobic regions might lower overall solubility in such environments.
Concentration Effects: Even if soluble, factors such as concentration and temperature can influence solubility. For instance, solubility may increase at elevated temperatures.

In conclusion, while this compound appears to possess a high degree of potential solubility in aqueous environments due to its polar and hydrophilic nature, specific solubility behavior should be confirmed experimentally for accurate applications.

Interesting facts

Interesting Facts About [5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] [3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)tetrahydrofuran-2-yl]methyl hydrogen phosphate

This compound, often referred to by its complex name, belongs to a fascinating class of molecules that exhibit significant biological activity. Here are some engaging insights:

Versatile Applications: Compounds of this nature are often investigated for their potential in medicinal chemistry, particularly for their roles in nucleoside metabolism and as enzyme inhibitors.
Synthesis Challenges: The synthesis of this compound may involve intricate multi-step processes that can test the ingenuity of chemists, requiring selective functional group transformations and advanced purification techniques.
Biochemical Significance: Its structural components suggest a close relationship with essential biochemical pathways, hinting at potential roles in cellular signaling or metabolic regulation.
Research Potential: Given its unique structure, this compound presents opportunities for novel therapeutic applications, especially in the fields of oncology and antiviral research.

As a student of chemistry, one might consider how the intricate layering of functional groups can lead to diverse mechanisms of action. The presence of both carbamoyl and phosphoryl groups enhances the compound's reactivity and potential interactions with biological macromolecules.

In exploring this compound, consider the questions it raises about molecular design and its implications in drug development. It's a reminder of how chemistry intersects not just with biology but also with the future of medicine.