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Ketazolam

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Identification
Molecular formula
C20H23ClN2O
CAS number
27272-75-1
IUPAC name
5-[3-(diethylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one
State
State

At room temperature, Ketazolam typically exists as a solid crystalline powder.

Melting point (Celsius)
98.00
Melting point (Kelvin)
371.15
Boiling point (Celsius)
360.00
Boiling point (Kelvin)
633.15
General information
Molecular weight
353.86g/mol
Molar mass
353.4600g/mol
Density
1.2089g/cm3
Appearence

Ketazolam is a white or almost white, crystalline powder.

Comment on solubility

Solubility of 5-[3-(diethylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one

The solubility of 5-[3-(diethylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one can be influenced by various factors. Here are some key points to consider regarding its solubility characteristics:

  • Polar vs. Nonpolar: This compound features both nonpolar aromatic rings and polar functional groups, which suggests that its solubility may vary depending on the solvent used.
  • Solvent Interaction: It is likely to be more soluble in organic solvents such as ethanol or methanol due to the presence of the diethylamino group, which can engage in hydrogen bonding.
  • Aqueous Solubility: In water, the solubility may be limited due to the hydrophobic character of the benzodiazepine structure, making it less effective in aqueous environments.
  • Temperature Effects: As with many chemical compounds, solubility can increase with temperature, so heating the solvent may enhance the dissolution process.
  • pH Influence: The ionization of the diethylamino group can also affect solubility. In highly acidic or basic environments, the compound's solubility may increase due to the formation of charged species.

In summary, the solubility of 5-[3-(diethylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one is not absolute and is influenced by the choice of solvent, temperature, and pH levels. Understanding these factors is crucial for predicting its behavior in different chemical environments.

Interesting facts

Insights into 5-[3-(diethylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one

5-[3-(diethylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one, a compound belonging to the benzodiazepine class, is notable for its pharmacological properties and potential applications in medicine. Here are some intriguing aspects of this compound:

  • Development of Sedatives and Anxiolytics: Benzodiazepines are primarily recognized for their sedative and anxiolytic effects. This specific compound may contribute to further developments in therapeutic agents targeting anxiety and sleep disorders.
  • Structure-Activity Relationship (SAR): The unique structure of this compound, characterized by its benzodiazepine core and the diethylamino propyl chain, emphasizes the importance of SAR studies in the design of more effective drugs. Analyzing how structural modifications influence activity can lead to the discovery of compounds with improved efficacy and safety profiles.
  • Intermolecular Interactions: The presence of functional groups within the compound allows for interesting intermolecular interactions. Exploring these can reveal insights into binding affinities and mechanisms of action at neurotransmitter receptors, particularly GABAA receptors.
  • Potential for New Therapeutics: Due to the increasing prevalence of mood disorders, the exploration of compounds like this benzodiazepine is crucial for developing new treatments that could address the unmet needs of patients.
  • Research Opportunities: As researchers delve into the pharmacokinetics and pharmacodynamics of this compound, opportunities arise for interdisciplinary studies, including chemistry, pharmacology, and medicine, to collaborate and innovate.

In conclusion, 5-[3-(diethylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one illustrates the profound impact that small chemical modifications can have on biological activity. Through continued research, this compound could become a key player in the advancement of therapeutic agents for mental health.

Synonyms
4231-97-4
11H-DIBENZO(b,e)(1,4)DIAZEPIN-11-ONE, 5,10-DIHYDRO-10-(3-(DIETHYLAMINO)PROPYL)-
10-(3-(Diethylamino)propyl)-5,10-dihydro-11H-dibenzo(b,e)(1,4)diazepin-11-one
10-[3-(diethylamino)propyl]-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one
BRN 0694169
DTXSID90195131