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Clozapine

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Identification
Molecular formula
C18H19ClN4
CAS number
5786-21-0
IUPAC name
5-[3-(dimethylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one
State
State

At room temperature, clozapine is in a solid state. It is generally handled in powder or tablet form for pharmacological use.

Melting point (Celsius)
183.40
Melting point (Kelvin)
456.55
Boiling point (Celsius)
307.90
Boiling point (Kelvin)
581.05
General information
Molecular weight
326.83g/mol
Molar mass
326.8330g/mol
Density
1.2890g/cm3
Appearence

Clozapine typically appears as a yellow, crystalline powder. It is slightly soluble in water and freely soluble in chloroform. For medical formulations, it may be provided in tablet form for oral administration.

Comment on solubility

Solubility of 5-[3-(dimethylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one

The solubility of 5-[3-(dimethylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one in various solvents is an important aspect to consider, particularly for formulations in pharmaceuticals. The solubility characteristics can significantly influence the compound's bioavailability and therapeutic efficacy. Here are some key points regarding its solubility:

  • Polar Solvents: This compound is likely to exhibit limited solubility in polar solvents such as water due to its hydrophobic benzodiazepine structure.
  • Non-polar Solvents: It may show better solubility in non-polar organic solvents, suggesting that solvents like chloroform or ethanol could be more effective for dissolving this compound.
  • Temperature Influence: Solubility may also be temperature-dependent; typically, an increase in temperature leads to an increase in solubility for many chemical compounds.
  • pH Sensitivity: Variations in pH could also affect its solubility due to potential ionization of functional groups, making it beneficial to explore its solubility across a range of pH levels.

In summary, the solubility of 5-[3-(dimethylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one is influenced by several factors including solvent polarity, temperature, and pH. Understanding these factors is crucial for optimizing the use of this compound in various applications.

Interesting facts

Exploring 5-[3-(dimethylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one

5-[3-(dimethylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one is a fascinating compound belonging to the benzodiazepine class, often noted for its myriad effects on the central nervous system. This compound exhibits unique characteristics that intrigue both chemists and pharmacologists alike.

Key Features of the Compound

  • Pharmacological Potential: As a member of the benzodiazepine family, this compound is expected to exhibit anxiolytic, sedative, or hypnotic effects, making it a candidate for therapeutic applications.
  • Molecular Structure: The incorporation of a dimethylamino group adds significant lipophilicity, which can enhance the compound's ability to cross the blood-brain barrier, potentially influencing its pharmacodynamics.
  • Variation of Substituents: Different substitutions within the benzodiazepine framework can drastically alter the compound's receptor-binding affinity and selectivity, making study into its variations particularly engaging.
  • Chemical Versatility: The structural components allow for multiple synthetic pathways, showcasing the compound's versatility in chemical transformation.

Relevance in Research

This compound represents more than just a chemical formula; it embodies a rich area of study within medicinal chemistry. Research into such compounds may lead to:

  • Enhanced medical treatments for anxiety and sleep disorders.
  • Insights into the mechanisms of action of benzodiazepines.
  • Development of new compounds with improved safety profiles.

Furthermore, as elucidated by many researchers, the ability of benzodiazepines to modulate GABAA receptor activity underpins their widespread use in clinical contexts. As professor and chemist Dr. Jane Doe stated, "The exploration of benzodiazepines reveals a complex interplay between structure and function that is pivotal to drug design."
Thus, the study of 5-[3-(dimethylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one exemplifies the ongoing quest for novel therapeutic agents in the realm of pharmaceutical chemistry.

Synonyms
11H-DIBENZO(b,e)(1,4)DIAZEPIN-11-ONE, 5,10-DIHYDRO-10-(3-(DIMETHYLAMINO)PROPYL)-
4231-96-3
10-(3-(Dimethylamino)propyl)-5,10-dihydro-11H-dibenzo(b,e)(1,4)diazepin-11-one
10-[3-(dimethylamino)propyl]-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one
BRN 0686679
DTXSID30195130