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Diazepam

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Identification
Molecular formula
C16H16N2O
CAS number
439-14-5
IUPAC name
5-[3-(methylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one
State
State

Diazepam is primarily in a solid state at room temperature. It appears as a crystalline powder.

Melting point (Celsius)
131.00
Melting point (Kelvin)
404.15
Boiling point (Celsius)
309.00
Boiling point (Kelvin)
582.15
General information
Molecular weight
284.32g/mol
Molar mass
284.7480g/mol
Density
1.3000g/cm3
Appearence

Diazepam appears as a colorless or white crystalline powder. It is odorless with a slightly bitter taste.

Comment on solubility

Solubility of 5-[3-(methylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one

The solubility of 5-[3-(methylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one is influenced by several factors due to its complex structural nature. This compound features a benzodiazepine core with a propyl side chain that is substituted with a methylamino group, contributing to its unique solubility characteristics.

Factors Affecting Solubility

  • Polarity: The presence of polar functional groups, such as the methylamino group, enhances solubility in polar solvents.
  • Hydrogen Bonding: The ability of the compound to participate in hydrogen bonding can significantly increase its solubility in polar solvents like water.
  • Temperature: As with many organic compounds, increased temperature generally leads to improved solubility.

While the specific solubility data for this compound in various solvents may not be widely available, it is often the case that benzodiazepines demonstrate variable solubility profiles based on their substitution patterns. In practical applications, it is essential to conduct empirical testing due to the compound’s structural intricacies and the diverse environments it may encounter.

In summary, understanding the solubility of this compound is crucial for its application in medicinal chemistry and pharmacology. Therefore, researchers should conduct experiments to ascertain solubility in relevant solvents to optimize formulations and therapeutic efficacy.

Interesting facts

Interesting Facts about 5-[3-(methylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one

This compound belongs to the class of benzodiazepines, which are a group of psychoactive drugs known for their sedative, anxiolytic, and muscle-relaxant properties. Benzodiazepines have a rich history and play a crucial role in modern medicine. Here are some interesting aspects of this specific compound:

  • Structural Complexity: The molecular structure of this compound features a unique combination of benzodiazepine and propyl amine components, which may contribute to its pharmacological effects.
  • Psychotropic Effects: Like many benzodiazepines, this compound has the potential for modulation of the central nervous system (CNS), making it useful in treating conditions such as anxiety, insomnia, and seizures.
  • Research Potential: The compound's distinctive structure opens up avenues for ongoing pharmacological research, particularly in terms of identifying its specific receptor affinities and therapeutic indices.
  • Design Implications: In medicinal chemistry, the incorporation of a methylamino group significantly influences the compound's biological activity, making it a point of interest for formulation strategies.
  • Safety Profile: As with all benzodiazepines, it's important to understand the safety profile, including potential withdrawal symptoms and the risk of dependency associated with prolonged use.

In summary, 5-[3-(methylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one exemplifies the fascinating intersection of chemical structure and therapeutic utility. Its ongoing study continues to shed light not only on benzodiazepine function but also on broader implications for mental health treatments.