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5-[3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-amine

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Identification
Molecular formula
C9H6F3N3O
CAS number
261951-85-3
IUPAC name
5-[3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-amine
State
State

At room temperature, 5-[3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-amine is found in a solid state as a crystalline powder.

Melting point (Celsius)
153.00
Melting point (Kelvin)
426.15
Boiling point (Celsius)
388.70
Boiling point (Kelvin)
661.85
General information
Molecular weight
215.16g/mol
Molar mass
215.1730g/mol
Density
1.6130g/cm3
Appearence

This compound typically appears as a white to off-white crystalline powder. Its form can vary slightly based on the manufacturing process, but it is generally uniform in color and texture.

Comment on solubility

Solubility of 5-[3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-amine

The solubility of 5-[3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-amine is a fascinating topic, particularly because of its unique chemical structure. This compound exhibits varying degrees of solubility depending on the solvent used. Here are some key points to consider:

  • Polarity of the Solvent: The presence of the trifluoromethyl group generally increases the hydrophobic characteristics, which can diminish solubility in polar solvents like water. However, it may show greater solubility in organic solvents such as acetone or dimethyl sulfoxide (DMSO).
  • Temperature Dependency: Like many organic compounds, the solubility may increase with temperature, allowing better dissolution in a suitable solvent when heated.
  • pH Influence: The amine functional group is a weak base; hence, solubility may vary significantly with pH. In more acidic environments, protonation could lead to increased solubility.

In summary, while 5-[3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-amine may not be highly soluble in water, its solubility can be maximized in organic solvents and under specific conditions. Understanding these solubility dynamics is crucial for applications in pharmaceuticals and materials science.

Interesting facts

Interesting Facts about 5-[3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-amine

The compound 5-[3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-amine, also known in certain circles by its abbreviated forms, holds unique attributes that make it a fascinating subject in the field of chemistry. This organic compound features a distinctive oxadiazole ring, known for its role in enhancing the biological activity and stability of molecules.

Key Features

  • Versatile Functionality: The presence of the oxadiazole moiety makes this compound a potential candidate for a variety of applications, including pharmaceuticals and agrochemicals.
  • Fluorine Effects: The trifluoromethyl group attached to the phenyl ring lends the compound unique electronic properties, enhancing its lipophilicity, which can influence the compound's interaction with biological targets.
  • Structural Diversity: This compound serves as a platform for the synthesis of various derivatives, which can be tailored for specific desired properties or activities in medicinal chemistry.

One of the notable aspects of 5-[3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-amine is its potential use in drug discovery. Compounds with oxadiazole structures have been investigated for their anti-inflammatory, antimicrobial, and anticancer activities. This raises the question:

"What therapeutic potentials remain undiscovered within structures like this?"

Furthermore, research on fluorinated compounds is on the rise due to their significance in improving metabolic stability and in enhancing binding affinity in drug candidates. As a scientist exploring this compound, imagine the endless possibilities for innovation in treatment methodologies.

In conclusion, the unique structural features of 5-[3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-amine make it a noteworthy compound in the realm of chemistry, with the potential to pave the way for future scientific breakthroughs.

Synonyms
5711-64-8
2-Amino-5-(alpha,alpha,alpha-trifluoro-m-tolyl)-,1,3,4-oxadiazole
1,3,4-OXADIAZOLE, 2-AMINO-5-(alpha,alpha,alpha-TRIFLUORO-m-TOLYL)-
DTXSID60205736
DTXCID90128227
5-[3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-amine
5-(3-(Trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-amine
CHEMBL2426232
5-[3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-ylamine
SCHEMBL25184601
SFKXKVUEXCFQLZ-UHFFFAOYSA-N
BDBM50440124
MFCD01710639
AKOS000162221
AS-43478
CS-0258015
EN300-68847
F2158-1518
Z285233732