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Berberine

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Identification
Molecular formula
C20H18NO4
CAS number
2086-83-1
IUPAC name
5-(3,4,5-trimethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline
State
State

At room temperature, berberine is a solid. It is typically found in the form of a crystalline powder, which is stable under normal conditions. The compound is known for its poor solubility in water, which is a factor in its preparation for various applications.

Melting point (Celsius)
176.00
Melting point (Kelvin)
449.15
Boiling point (Celsius)
355.00
Boiling point (Kelvin)
628.15
General information
Molecular weight
336.36g/mol
Molar mass
336.3620g/mol
Density
1.3600g/cm3
Appearence

Berberine appears as a bright yellow crystalline solid. It is known for its intense yellow coloration, which has made it historically significant as a dye. The compound is often encountered in a powder form used in research or as tablets in dietary supplements.

Comment on solubility

Solubility of 5-(3,4,5-trimethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline

The solubility of the compound 5-(3,4,5-trimethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline in various solvents can greatly influence its chemical behavior and potential applications. Here are some key points to consider:

  • Polar solvents: The presence of methoxy groups can enhance solubility in polar solvents like water and ethanol due to hydrogen bonding.
  • Non-polar solvents: The aromatic nature of the isoquinoline structure suggests better solubility in non-polar solvents such as hexane and toluene, driven by π-π interactions.
  • Temperature effects: An increase in temperature often enhances solubility for many compounds; thus, investigating temperature variations can yield significant insights.
  • pH dependence: As with many organic compounds, the solubility may vary with changes in pH, particularly if functional groups can gain or lose protons.

In research and practical applications, understanding the solubility characteristics of this compound is crucial, as it could lead to varied results in biological assays or chemical reactions. Consequently, a comprehensive study involving solubility tests in multiple solvents will provide a clearer picture of this compound's utility.

Interesting facts

Interesting Facts about 5-(3,4,5-trimethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline

The compound 5-(3,4,5-trimethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline is a fascinating member of the isoquinoline family, which consists of a diverse array of alkaloids known for their complex structures and remarkable biological activities. Here are some intriguing points about this compound:

  • Natural Origin: Isoquinolines are often derived from natural sources, which means that compounds like this can exhibit various biological properties. Some isoquinoline derivatives are known for their roles in traditional medicine.
  • Structural Beauty: The unique dioxolo ring in this compound contributes to its structural complexity. This feature may enhance its reactivity and biological interactions, making it an interesting topic for chemists.
  • Functional Groups: The presence of trimethoxy groups suggests potential for strong electron-donating properties. This can significantly influence the compound's reactivity and interactions with biological targets.
  • Research Potential: Given its structure and functional features, this compound could be a target for research in pharmacology, especially in the context of developing new drugs or therapies with specific mechanisms of action.
  • Biological Activity: Similar compounds in the isoquinoline class have shown various activities, including anti-inflammatory and anticancer effects. Studying this compound could reveal new insights into its potential therapeutic applications.

As researchers continue to explore the depths of such complex chemical structures, the potential for discovering novel applications remains vast. Conditions under which these compounds are synthesized and the various reactions they can undergo are key areas for future study, as they hold promise for advancements in [bioorganic chemistry](https://en.wikipedia.org/wiki/Bioorganic_chemistry) and drug development.

In summary, 5-(3,4,5-trimethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline is not merely a chemical compound; it stands at the intersection of chemistry and biology, making it a compelling area of study for scientists and students alike.