Skip to main content

5-[(3,5-dimethylphenoxy)methyl]oxazolidin-2-one

ADVERTISEMENT
Identification
Molecular formula
C13H17NO3
CAS number
171832-17-4
IUPAC name
5-[(3,5-dimethylphenoxy)methyl]oxazolidin-2-one
State
State

At room temperature, 5-[(3,5-dimethylphenoxy)methyl]oxazolidin-2-one is in a solid state.

Melting point (Celsius)
117.50
Melting point (Kelvin)
390.65
Boiling point (Celsius)
362.50
Boiling point (Kelvin)
635.65
General information
Molecular weight
235.27g/mol
Molar mass
235.2740g/mol
Density
1.1528g/cm3
Appearence

5-[(3,5-dimethylphenoxy)methyl]oxazolidin-2-one is a solid organic compound with a crystalline appearance. It is typically white or off-white in color and is used as an intermediate in organic synthesis.

Comment on solubility

Solubility of 5-[(3,5-dimethylphenoxy)methyl]oxazolidin-2-one

The solubility of 5-[(3,5-dimethylphenoxy)methyl]oxazolidin-2-one is a nuanced topic that reflects its molecular structure and functional groups. This compound features both hydrophobic and hydrophilic characteristics, thus influencing its solubility behavior. Here are some key points to consider:

  • Hydrophilicity: The presence of the oxazolidinone ring, containing polar carbonyl and nitrogen functionalities, typically promotes solubility in polar solvents like water.
  • Hydrophobicity: Conversely, the 3,5-dimethylphenoxy substituent contributes to a more significant hydrophobic character, which may hinder its solubility in purely aqueous environments.
  • Solvent Effects: The solubility of this compound can be enhanced in mixed solvents or organic solvents such as ethanol or acetone, where both polar and non-polar interactions can occur.
  • Temperature Dependence: As with many substances, increased temperature may improve solubility, although specific experimental data would be necessary to quantify this effect.

In conclusion, while the solubility of 5-[(3,5-dimethylphenoxy)methyl]oxazolidin-2-one is influenced by its unique structure and the interplay between its hydrophilic and hydrophobic parts, it is essential to explore empirical data to fully understand its behavior in various solvents. As they say, "The solubility spectrum can reveal the hidden complexities of chemical interactions."

Interesting facts

Interesting Facts About 5-[(3,5-Dimethylphenoxy)methyl]oxazolidin-2-one

5-[(3,5-dimethylphenoxy)methyl]oxazolidin-2-one is an intriguing compound, especially within the field of medicinal chemistry. This compound belongs to the oxazolidinone class of antibiotics, a category that has gained prominence for its efficacy against Gram-positive bacteria. Here are some intriguing aspects to consider:

  • Medicinal Relevance: Oxazolidinones have been significant in treating infections caused by resistant bacteria. Their unique mechanism of action involves inhibiting protein synthesis by binding to the bacterial ribosome.
  • Structural Characteristics: The presence of a dimethylphenoxy group within its structure lends this compound unique chemical properties, enhancing its biological activity while also influencing its pharmacokinetics.
  • Research Potential: The design and optimization of oxazolidinone derivatives are ongoing areas of research. Scientists are continually exploring modifications to improve their efficacy and reduce any potential side effects, paving the way for the development of new therapeutics.
  • Pharmacological Studies: Studies have shown that compounds like this one may also exhibit anti-inflammatory properties, which could broaden their therapeutic applications beyond infectious diseases.
  • Synthetic Challenges: The synthesis of oxazolidinones often involves sophisticated organic chemistry techniques, demanding a thorough understanding of reaction mechanisms and compound stability. This makes it an exciting challenge for chemistry students!

In summary, 5-[(3,5-dimethylphenoxy)methyl]oxazolidin-2-one represents a compelling intersection between organic chemistry and medicinal application, showcasing the importance of chemical innovation in combating microbial resistance. As researchers delve deeper, the potential for new applications and improved drug formulations remains vast.

Synonyms
METAXALONE
1665-48-1
Zorane
Methaxalonum
Metaxalon
Methoxolone
Metazolone
2-Oxazolidinone, 5-[(3,5-dimethylphenoxy)methyl]-
AHR-438
Metaxalona
Metaxalonum [Latin]
Metaxalonum [INN-Latin]
Metassalone
Metaxalona [INN-Spanish]
Metaxalonum
Flexura
NSC 170959
5-(3,5-Xyloloxymethyl)oxazolidin-2-one
CL 39,148
5-[(3,5-Xylyloxy)methyl]-2-oxazolidinone
2-Oxazolidinone, 5-((3,5-xylyloxy)methyl)-
HSDB 3236
5-((3,5-Dimethylphenoxy)methyl)-2-oxazolidinone
5-((3,5-Xylyloxy)methyl)-2-oxazolidinone
EINECS 216-777-6
UNII-1NMA9J598Y
NSC-170959
BRN 0884592
1NMA9J598Y
DTXSID3023269
2-Oxazolidinone, 5-((3,5-dimethylphenoxy)methyl)-
NSC170959
DTXCID103269
Metaxalonum (Latin)
Metaxalonum (INN-Latin)
Metaxalona (INN-Spanish)
2-Oxazolidinone, 5-[(3,5-xylyloxy)methyl]-
METAXALONE (MART.)
METAXALONE [MART.]
METAXALONE (USP-RS)
METAXALONE [USP-RS]
5-[(3,5-Dimethylphenoxy)methyl]-2-oxazolidinone
METAXALONE (USP MONOGRAPH)
METAXALONE [USP MONOGRAPH]
metaxalone tablet
216-777-6
Skelaxin
5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one
Metaxolone
Metazalone
Metassalone [DCIT]
AHR 438
5-[(3,5-Dimethylphenoxy)methyl]-1,3-oxazolidin-2-one
MFCD00867700
5-[(3,5-dimethylphenoxy)methyl]oxazolidin-2-one
5-(3,5-dimethylphenoxymethyl)-1,3-oxazolidin-2-one
MLS003106749
CHEBI:6797
NCGC00095116-01
5-(3,5-dimethylphenoxymethyl)-2-oxazolidinone
Metaxalona [Spanish]
CAS-1665-48-1
Metaxalone [USAN:INN:BAN]
SR-05000001978
5-((3,5-Dimethylphenoxy)methyl)-1,3-oxazolidin-2-one
.meta.Xalone
.meta.Zalone
.meta.Zolone
.meta.Xalon
Skelaxin (TN)
Metaxalone (Standard)
Spectrum_001741
METAXALONE [MI]
SpecPlus_000656
Metaxalone (USP/INN)
METAXALONE [INN]
Spectrum2_000548
Spectrum3_001666
Spectrum4_000612
Spectrum5_001685
METAXALONE [HSDB]
METAXALONE [USAN]
METAXALONE [VANDF]
METAXALONE [WHO-DD]
Oprea1_438855
SCHEMBL34908
BSPBio_003451
KBioGR_001164
KBioSS_002221
DivK1c_006752
SPECTRUM1504229
Metaxalone;AHR-438;Skelaxin
SPBio_000595
GTPL7609
CHEMBL1079604
METAXALONE [ORANGE BOOK]
Metaxalone, >=98% (HPLC)
HY-B0678R
KBio1_001696
KBio2_002221
KBio2_004789
KBio2_007357
KBio3_002671
HMS1922H07
HMS2093C22
Pharmakon1600-01504229
BCP28377
HY-B0678
Tox21_111428
WLN: T5MVOTJ D1OR C1 E1
2-Oxazolidinone,5-xylyloxy)methyl]-
CCG-39592
NSC758703
s3730
STL450994
STL451511
AKOS009035315
Tox21_111428_1
DB00660
FD25129
FS-3218
NSC-758703
NCGC00095116-02
NCGC00095116-03
NCGC00095116-05
SMR001821638
SY052772
SBI-0052859.P002
2-Oxazolidinone,5-dimethylphenoxy)methyl]-
DB-043656
M2578
NS00000535
5-(3,5-dimethylphenoxy)methyl-2-oxazolidinone
C07934
D00773
EN300-119839
AB00053284_04
Q6823309
SR-05000001978-1
SR-05000001978-3
BRD-A94709349-001-02-6
BRD-A94709349-001-03-4
BRD-A94709349-001-08-3
Z106952910
5-[(3,5-Dimethylphenoxy)methyl]-1,3-oxazolidin-2-one #
5-{[(3,5-dimethylphenyl)oxy]methyl}-1,3-oxazolidin-2-one
5-[(3,5-dimethylphenoxy)methyl]-4,5-dihydro-1,3-oxazol-2-ol
Metaxalone, United States Pharmacopeia (USP) Reference Standard