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Estradiol

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Identification
Molecular formula
C18H24O2
CAS number
50-28-2
IUPAC name
5-[(3S,5S,10R,13R,14S,17R)-3,5,14-trihydroxy-10,13-dimethyl-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pyran-2-one
State
State

Estradiol is typically found as a solid at room temperature.

Melting point (Celsius)
172.00
Melting point (Kelvin)
445.15
Boiling point (Celsius)
580.00
Boiling point (Kelvin)
853.15
General information
Molecular weight
288.42g/mol
Molar mass
288.4240g/mol
Density
1.2567g/cm3
Appearence

Estradiol appears as a white crystalline powder. It is odorless and stable under recommended storage conditions. The compound typically has poor solubility in water but is soluble in alcohols and some organic solvents.

Comment on solubility

Solubility of 5-[(3S,5S,10R,13R,14S,17R)-3,5,14-trihydroxy-10,13-dimethyl-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pyran-2-one

The solubility of complex organic compounds, such as 5-[(3S,5S,10R,13R,14S,17R)-3,5,14-trihydroxy-10,13-dimethyl-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pyran-2-one, can be influenced by various factors. In general, high molecular weight compounds with multiple hydroxyl (–OH) groups tend to exhibit improved solubility in polar solvents. This particular compound features multiple hydroxyl groups, which are hydrophilic and can form hydrogen bonds with water, potentially enhancing its solubility.

Consider the following aspects when evaluating solubility:

  • Polarity: The presence of hydroxyl groups typically increases the polarity of compounds, influencing their interaction with polar solvents like water.
  • Hydrogen bonding: The ability of this compound to engage in hydrogen bonding with solvents is likely to facilitate its solubility in polar environments.
  • Hydrophobic regions: Despite its polar characteristics, hydrophobic segments within the compound may hinder solubility to some degree, particularly in non-polar solvents.
  • Temperature: Solubility may increase with temperature; thus, understanding the compound's behavior under varying thermal conditions is crucial.

In conclusion, while the potential for solubility in polar solvents exists due to the abundant hydroxyl groups, empirical testing in various solvent systems would be paramount to determine the actual solubility trends of this intricate compound. As always, factors such as molecular interactions and solvent choice play a pivotal role in defining solubility profiles.

Interesting facts

Interesting Facts about 5-[(3S,5S,10R,13R,14S,17R)-3,5,14-trihydroxy-10,13-dimethyl-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pyran-2-one

This complex compound, often referred to in scientific literature for its unique structural characteristics, belongs to a larger class of molecules known for their diverse biological activities. Here are some fascinating insights:

  • Natural Origins: Many compounds similar to this one are derived from natural sources, particularly plants, which showcase a rich diversity of structural forms and functional properties.
  • Stereochemistry: The presence of multiple chiral centers in this molecule indicates a rich stereochemical landscape, which is significant for understanding how the compound interacts biologically.
  • Biological Relevance: Compounds like this often exhibit notable pharmacological activities, making them subjects of interest in medicinal chemistry and drug development.
  • Research Trails: Studies may focus on the compound's potential as a therapeutic agent, exploring various mechanisms of action against diseases.

In the world of organic chemistry, compounds with such intricate structures often prompt researchers to explore:

  • Potential modifications to enhance biological activity or selectivity
  • Methods of synthesis to produce the compound efficiently in the lab
  • Interactions with biological targets, which could lead to advances in medicinal applications

As we delve deeper into the study of complex organic compounds, it's essential to remember that understanding their structure not only sheds light on their function but also paves the way for innovations in therapeutic strategies. It’s truly a reminder of the connections between chemical structures and their profound impacts on health and biology.