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Folinic acid

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Identification
Molecular formula
C20H23N7O7P
CAS number
1492-18-8
IUPAC name
[[5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] (2,3,4-trihydroxy-3-methyl-butyl) hydrogen phosphate
State
State

At room temperature, folinic acid is typically in a solid state. It is stored in a desiccated form to maintain stability.

Melting point (Celsius)
120.00
Melting point (Kelvin)
393.15
Boiling point (Celsius)
217.00
Boiling point (Kelvin)
490.15
General information
Molecular weight
511.49g/mol
Molar mass
511.4910g/mol
Density
2.0670g/cm3
Appearence

The compound typically appears as a white to off-white crystalline powder. It is odorless and may form fine, whitish particles in the air.

Comment on solubility

Solubility of [5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl (2,3,4-trihydroxy-3-methyl-butyl) hydrogen phosphate

This fascinating compound, with the chemical formula C20H23N7O7P, presents intriguing solubility characteristics due to its complex structure featuring multiple functional groups that can influence its interactions with solvents.

Factors Influencing Solubility

The solubility of this compound can typically be assessed based on the following factors:

  • Hydrophilicity: The presence of multiple hydroxyl groups (-OH) enhances the ability of the compound to interact with polar solvents, such as water.
  • Ionization: The phosphonate group can exist in ionic form under certain conditions, which may further improve solubility in aqueous environments.
  • Molecular Size: As the compound contains a significant molecular size attributed to its complex structure, solubility may decrease compared to smaller molecules.
  • Concentration and Temperature: As with many compounds, solubility is affected by concentration and temperature, with higher temperatures often increasing solubility.

It is noteworthy that while one might expect this compound to be soluble in polar solvents, its unique structure could lead to variances in solubility that may only be revealed through experimental investigation. As stated, "the solubility is often a dance between structure and environment" exemplifying just how intricate this relationship can be.

In summary, while the overall solubility profile of C20H23N7O7P may lean towards being soluble in polar solvents, empirical testing is essential to grasp a complete understanding of its behavior in solution.

Interesting facts

Interesting Facts about [5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl (2,3,4-trihydroxy-3-methyl-butyl) hydrogen phosphate

This compound, often referred to in biochemical circles for its complex structure, embodies the fascinating interplay between organic chemistry and biochemistry. Here are some key points that highlight its significance:

  • Phosphorylation Potential: The presence of the phosphoryl group suggests its role in transferring phosphate groups, a fundamental mechanism in cellular processes like energy transfer and signal transduction.
  • Biological Relevance: Compounds containing pyrimidine structures are widely recognized for their occurrence in nucleic acids, playing essential roles in genetic coding and regulation.
  • Synthetic Applications: Its intricate architecture makes it a potential candidate in synthesizing nucleoside analogs, which are invaluable in the development of antiviral and anticancer drugs.
  • Hydroxyl Modifications: The multiple hydroxyl groups not only enhance solubility but also facilitate interactions with biological targets, thus influencing the compound's therapeutic efficacy.
  • Research Opportunities: The pathway of studying such phosphates opens doors to discovering novel biochemical reactions and understanding enzyme interactions at a molecular level.

In summary, this compound stands out due to its potential applications in medicinal chemistry and molecular biology. The fusion of functional groups within this molecule showcases the creativity and complexity inherent in chemical research. As scientists continue to explore its properties, it remains a subject of curiosity and innovation in the field.

Synonyms
4-Diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME)
PD042053