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Iododeoxyuridine

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Identification
Molecular formula
C9H11IN2O5P
CAS number
54-42-2
IUPAC name
[5-(4-amino-5-iodo-2-oxo-pyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate
State
State

At room temperature, iododeoxyuridine is primarily found in a solid state, ideal for storage and handling in laboratory environments. Its solid form also facilitates its use in synthesis and various experimental protocols.

Melting point (Celsius)
189.00
Melting point (Kelvin)
462.15
Boiling point (Celsius)
385.00
Boiling point (Kelvin)
658.15
General information
Molecular weight
370.06g/mol
Molar mass
370.1320g/mol
Density
1.2000g/cm3
Appearence

Iododeoxyuridine is a crystalline compound that typically appears as a white to off-white powder. It is often used in scientific research and pharmaceutical applications, where its appearance is crucial for identification and purity assessments.

Comment on solubility

Solubility of [5-(4-amino-5-iodo-2-oxo-pyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate

The compound [5-(4-amino-5-iodo-2-oxo-pyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate exhibits intriguing solubility characteristics. Understanding its solubility is crucial for its potential applications and interactions in various environments. Here are some key points to consider:

  • Aqueous Solubility: The presence of the dihydrogen phosphate group typically enhances solubility in water due to its ability to form hydrogen bonds with water molecules.
  • Organic Solvents: Given the complex organic structure, its solubility in organic solvents may vary significantly. Solvents such as dimethyl sulfoxide (DMSO) and methanol might facilitate dissolution due to their polar nature.
  • Temperature Dependence: Solubility often increases with temperature; hence, solubility studies should consider a range of temperatures to determine its full profile.
  • pH Sensitivity: As with many phosphate-containing compounds, the pH of the environment can greatly influence solubility. It may demonstrate increased solubility in acidic conditions compared to neutral or basic environments.

In summary, the solubility of [5-(4-amino-5-iodo-2-oxo-pyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate is characterized by several important factors, including its interaction with water and organic solvents, temperature, and pH. These factors make it a compound of interest for further investigations and applications in various fields.

Interesting facts

Interesting Facts about [5-(4-amino-5-iodo-2-oxo-pyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate

This compound presents a fascinating blend of pharmacological potential and structural complexity. Here are some intriguing aspects:

  • Pharmacological Applications: Due to its unique structure, this compound may play a significant role in medicinal chemistry, potentially acting as an important intermediate in the synthesis of nucleoside analogs.
  • Structural Features: The presence of the pyrimidine ring in the structure indicates the compound could exhibit important biological activity, given that pyrimidines are a common motif in many biological molecules, including DNA and RNA.
  • Potential as a Therapeutic Agent: The introduction of amino and iodo functional groups may enhance its interaction with biological targets, making it a candidate for further studies in drug development, particularly in antiviral or anticancer therapies.
  • Hydrogen Phosphate Group: The dihydrogen phosphate moiety contributes to the compound's solubility characteristics and could influence its bioavailability, essential factors in drug metabolism and efficacy.

In summary, the compound's intricate structure and potential biological applications make it a subject of interest for researchers seeking new therapeutic agents. As the field of medicinal chemistry advances, the exploration of compounds like this one could lead to groundbreaking discoveries and treatments.