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Sulfathiazole

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Identification
Molecular formula
C9H9N3O2S2
CAS number
72-14-0
IUPAC name
5-(4-aminophenyl)sulfonylthiazol-2-amine
State
State

Sulfathiazole is typically found in a solid state at room temperature.

Melting point (Celsius)
202.00
Melting point (Kelvin)
475.15
Boiling point (Celsius)
285.00
Boiling point (Kelvin)
558.15
General information
Molecular weight
255.32g/mol
Molar mass
255.3180g/mol
Density
1.4900g/cm3
Appearence

Sulfathiazole typically appears as a white or off-white crystalline powder. It may also be found in a granular form. The compound is often used in its pure form for scientific purposes and pharmaceutical applications.

Comment on solubility

Solubility of 5-(4-aminophenyl)sulfonylthiazol-2-amine

The solubility of 5-(4-aminophenyl)sulfonylthiazol-2-amine can be quite intricate, influenced by several factors that are essential to understand when considering its use in various applications.

Factors Affecting Solubility:

  • Polarity: The presence of both amino and sulfonyl functional groups in the structure enhances its polar characteristics, potentially improving its solubility in polar solvents.
  • Temperature: Elevated temperatures often increase solubility, thus dissolving higher concentrations of the compound when heated.
  • pH Levels: The ionization state of the amino groups can vary depending on the pH, which may affect solubility in aqueous solutions.
  • Solvent Choice: Compatibility with certain solvents such as water, alcohols, or DMSO will greatly impact its solubility behavior.

It is essential to note that due to its unique structure, as stated, "The balance between hydrophilic and hydrophobic characteristics plays a pivotal role." This means that while it may dissolve easily in certain environments, it might exhibit limited solubility in others, particularly non-polar solvents.

In summary, understanding the solubility of 5-(4-aminophenyl)sulfonylthiazol-2-amine is crucial for its utilization in pharmaceuticals and other chemical applications. The interplay of various factors determines both its efficacy and functionality in different settings.

Interesting facts

5-(4-Aminophenyl)sulfonylthiazol-2-amine: An Overview

The compound 5-(4-aminophenyl)sulfonylthiazol-2-amine is a fascinating molecule in the realm of medicinal chemistry, known for its diverse applications and potential therapeutic benefits.

Key Features

  • Pharmacological Relevance: This compound has shown promise as an inhibitor in various biological pathways, making it a potential candidate for drug development.
  • Structural Elements: It features a thiazole ring, which is known for its roles in biological activity, enhancing the compound's ability to interact with biological systems.
  • Versatile Functional Groups: The presence of both amino and sulfonyl groups contributes to its chemical reactivity and pharmaceutical properties, leading to potential anti-inflammatory and anti-cancer effects.

Scientific Significance

Researchers find 5-(4-aminophenyl)sulfonylthiazol-2-amine intriguing due to its dual nature, bridging both organic synthesis and medicinal applications. As noted by scientists, “The intricate balance of functional groups aids in targeting specific enzymes, offering therapeutic avenues previously unexplored.”

Applications

  • Used in the development of novel pharmaceuticals aimed at treating chronic diseases.
  • Investigated as a tool in biochemical research for studying enzyme mechanisms.
  • Possesses potential applications in agrochemistry, especially in developing pest control agents.

The study of this compound not only adds to the fundamental understanding of thiazole-derived compounds but also opens up possibilities for innovative drug design strategies. Its unique characteristics make it a compound worth exploring further in both academic and industrial settings.

Synonyms
Thiazosulfone
THIAZOLSULFONE
Thiazosulfonum
Thiazol sulfone
Tiazosulfona
Tiazosolfone
Thiazosulfone [INN]
2-Amino-5-sulfanilylthiazole
Tiazosolfone [DCIT]
UNII-WE45JZI7YO
WE45JZI7YO
2-Amino-5-(p-aminophenylsulfonyl)thiazole
Thiazosulfonum [INN-Latin]
Tiazosulfona [INN-Spanish]
Thiazosulfone (INN)
Thiazole, 2-amino-5-sulfanilyl-
NSC 1884
THIAZOLSULFONE [MI]
THIAZOSULFONE [MART.]
DTXSID80197088
2-Thiazolamine, 5-((4-aminophenyl)sulfonyl)-
2-Thiazolamine, 5-[(4-aminophenyl)sulfonyl]-
Thiazosulfonum (INN-Latin)
Tiazosulfona (INN-Spanish)
THIAZOSULFONE (MART.)
DTXCID90119579
Thiazole, 2-amino-5-sulfanilyl-(8CI)
2-Thiazolamine, 5-((4-aminophenyl)sulfonyl)-(9CI)
473-30-3
Promizole
thiazolesulfone
Thiazolsulphone
Thiazosulfon
Thiazosulphone
5-(4-aminophenyl)sulfonyl-1,3-thiazol-2-amine
NSC-1884
2-Amino-5-sulfanilylthiazole; NSC 1884; Promizol; Promizole
Promizol
2-amino-5-(4-aminophenylsulfonyl)thiazole
Promizole (TN)
5-((4-Aminophenyl)sulfonyl)thiazol-2-amine
SCHEMBL152559
CHEMBL2107139
NSC1884
CHEBI:135045
KVEZIRCKNOTGKY-UHFFFAOYSA-N
5-(4-aminophenyl)sulfonylthiazol-2-amine
DB-338775
NS00122998
D02522
5-[(4-aminophenyl)sulfonyl]-1,3-thiazol-2-ylamine
Q27292585