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Clotrimazole

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Identification
Molecular formula
C10H9ClN2S
CAS number
23593-75-1
IUPAC name
5-(4-chlorophenyl)-1-methyl-imidazole-2-thiol
State
State

Clotrimazole is typically in a solid state at room temperature.

Melting point (Celsius)
147.00
Melting point (Kelvin)
420.20
Boiling point (Celsius)
445.30
Boiling point (Kelvin)
718.50
General information
Molecular weight
220.71g/mol
Molar mass
220.7200g/mol
Density
1.2000g/cm3
Appearence

Clotrimazole typically appears as a white or slightly yellow crystalline powder.

Comment on solubility

Solubility of 5-(4-chlorophenyl)-1-methyl-imidazole-2-thiol

The solubility of 5-(4-chlorophenyl)-1-methyl-imidazole-2-thiol can be influenced by various factors, including temperature, pH, and the presence of other solutes. This compound, which contains a thiol group (-SH), may exhibit unique solubility characteristics due to its chemical structure.


Solubility Characteristics:

  • Polar vs Non-Polar: The presence of the thiol functional group generally contributes to an increase in polarity, suggesting that this compound may be more soluble in polar solvents such as water or alcohols.
  • Solvent Compatibility: Given its structural features, it may also find solubility in various organic solvents like dimethyl sulfoxide (DMSO) or acetonitrile, which can interact favorably with polar and non-polar regions.
  • pH Dependence: The solubility might be pH-dependent, as the ionization of the thiol group can lead to varying solubility in acidic or alkaline environments.
  • Temperature Factors: An increase in temperature generally increases solubility for most solids, so higher temperatures may enhance the solubility of this compound.

In summary, while specific numerical solubility values may not always be readily available, it’s reasonable to suggest that 5-(4-chlorophenyl)-1-methyl-imidazole-2-thiol could demonstrate significant solubility in both polar and suitably chosen organic solvents, influenced by environmental conditions. Understanding these solubility properties can be crucial for applications involving this compound.

Interesting facts

Interesting Facts about 5-(4-chlorophenyl)-1-methyl-imidazole-2-thiol

5-(4-chlorophenyl)-1-methyl-imidazole-2-thiol is a fascinating compound that bridges the worlds of organic chemistry and medicinal applications. Here are some intriguing insights about this versatile molecule:

  • Biological Significance: This compound is recognized for its potential as a pharmacophore, which is a molecular framework that can be used for drug design targeting various biological pathways.
  • Structural Features: The presence of both a thiol group and a substituted aromatic ring offers interesting reactivity patterns, making it a significant compound for synthesizing derivatives and studying their biological activities.
  • Research Applications: Its unique structure has led to applications in fields such as cancer research, antifungal agents, and as a marker in biochemical pathways. For instance, imidazole derivatives are often studied for their role in enzyme inhibition.
  • Chlorinated Aromatics: The 4-chlorophenyl substituent enhances the compound's lipophilicity, potentially improving its bioavailability in biological systems.
  • Environmental Impact: The study of such compounds is essential to understanding their environmental behavior, particularly in how chlorinated compounds can persist and accumulate.

As scientists continue to explore the chemical properties and therapeutic potential of 5-(4-chlorophenyl)-1-methyl-imidazole-2-thiol, its contributions may extend into new drug discovery and development avenues.