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Gallopamil

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Identification
Molecular formula
C27H29NO4
CAS number
16662-47-8
IUPAC name
5-[4-hydroxy-3-[1-hydroxy-4-(6-hydroxy-8-methoxy-1,3-dimethyl-3,4-dihydroisoquinolin-5-yl)-8-methoxy-6-methyl-2-naphthyl]-5-methoxy-7-methyl-1-naphthyl]-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline-6,8-diol
State
State

At room temperature, Gallopamil is in a solid state. This compound remains stable under standard laboratory conditions and is commonly used in its crystalline form for pharmaceutical applications.

Melting point (Celsius)
113.00
Melting point (Kelvin)
386.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
411.53g/mol
Molar mass
410.5270g/mol
Density
1.3600g/cm3
Appearence

Gallopamil is typically found as a white to off-white crystalline powder. It may appear slightly pale depending on the purity and specific form used. Being a fine powder, it can form clumps when exposed to air for prolonged periods due to moisture absorption.

Comment on solubility

Solubility of 5-[4-hydroxy-3-[1-hydroxy-4-(6-hydroxy-8-methoxy-1,3-dimethyl-3,4-dihydroisoquinolin-5-yl)-8-methoxy-6-methyl-2-naphthyl]-5-methoxy-7-methyl-1-naphthyl]-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline-6,8-diol (C27H29NO4)

The solubility profile of this complex organic compound is influenced by its intricate molecular structure, which features multiple functional groups and a significant degree of methylation. Here are some key considerations regarding its solubility:

  • Polarity: The presence of hydroxyl (–OH) groups typically increases the compound's polarity, enhancing its potential solubility in polar solvents like water.
  • Hydrophobic Regions: Conversely, the hydrocarbon portions of the molecule may render it less soluble in water, promoting solubility in organic solvents such as ethanol or methanol.
  • Crystal Structure: The specific crystalline form can affect solubility; more amorphous forms tend to dissolve more readily than their crystalline counterparts.
  • pH Dependency: Given the presence of hydroxyl groups, solubility may also be influenced by pH levels, which can impact the ionization state of the molecule.

As a result, while the compound may exhibit moderate solubility in aqueous solutions due to its polar functional groups, a thorough experimental evaluation is essential to ascertain the exact solubility characteristics. Various solvents should be tested to understand better how this compound behaves under different conditions.

Interesting facts

Interesting Facts about 5-[4-hydroxy-3-[1-hydroxy-4-(6-hydroxy-8-methoxy-1,3-dimethyl-3,4-dihydroisoquinolin-5-yl)-8-methoxy-6-methyl-2-naphthyl]-5-methoxy-7-methyl-1-naphthyl]-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline-6,8-diol

This intricate compound, belonging to the family of isoquinolines, exhibits a wealth of fascinating properties and potential applications. Here are some notable aspects:

  • Structural Complexity: Its structure is a testament to molecular diversity, showcasing multiple functional groups and stereochemistry, which could lead to unique biological activities.
  • Biological Activity: Many isoquinoline derivatives have been studied for their pharmacological properties, including antioxidant, antimicrobial, and antitumor activities. This compound could be a candidate for further research in medicinal chemistry.
  • Synthesis Pathways: The synthesis of such complex molecules often involves multi-step reactions, including asymmetric synthesis and modified reagents that challenge the creativity of chemists in the lab.
  • Natural Products: Compounds with similar structures can often be found in nature, particularly in plants used in traditional medicine, which leads to interesting studies in ethnobotany.
  • Future Potential: As scientific research evolves, the quest for new therapeutic agents continues. The distinctive characteristics of this compound may open doors for new classes of pharmaceuticals targeting neurological disorders.

In conclusion, the study of such a complex compound not only enhances our understanding of chemical intricacies but also paves the way for innovations in drug discovery and development. The exploration of isoquinolines remains a vibrant field within organic and medicinal chemistry.