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Amoxapine

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Identification
Molecular formula
C17H16ClN3O
CAS number
14028-44-5
IUPAC name
5-(4-methylpiperazin-1-yl)-6H-benzo[b][1]benzothiepin-5-ol
State
State

At room temperature, Amoxapine is in the form of a solid, specifically a crystalline powder.

Melting point (Celsius)
159.00
Melting point (Kelvin)
432.15
Boiling point (Celsius)
561.60
Boiling point (Kelvin)
834.80
General information
Molecular weight
313.42g/mol
Molar mass
313.4210g/mol
Density
1.2646g/cm3
Appearence

Amoxapine is typically a white to off-white crystalline powder. It is used primarily as an antidepressant and may be found in the form of tablets for pharmaceutical use.

Comment on solubility

Solubility of 5-(4-methylpiperazin-1-yl)-6H-benzo[b][1]benzothiepin-5-ol

The solubility of 5-(4-methylpiperazin-1-yl)-6H-benzo[b][1]benzothiepin-5-ol can be characterized as follows:

  • Polar and Non-Polar Solvents: This compound exhibits varying solubility in different solvents. Generally, it is expected to have better solubility in polar solvents such as dimethyl sulfoxide (DMSO) or methanol due to the presence of nitrogen atoms in its structure.
  • Saturation Point: The saturation point of this compound in a given solvent is primarily influenced by its molecular structure, particularly the hydrophobic benzo[b][1]benzothiepin moiety which can lead to limited solubility in non-polar solvents.
  • Temperature Influence: Increased temperature tends to enhance solubility for many compounds, and this may also hold true for 5-(4-methylpiperazin-1-yl)-6H-benzo[b][1]benzothiepin-5-ol. Higher temperatures can disrupt intermolecular forces and aid solvation.
  • Practical Applications: Understanding its solubility is crucial, especially in the fields of pharmaceuticals where solubility can impact bioavailability and overall efficacy. Compounds with low solubility may require formulations or additives to improve their dissolution in biological systems.

In conclusion, while 5-(4-methylpiperazin-1-yl)-6H-benzo[b][1]benzothiepin-5-ol has defined solubility traits, investigating its behavior in various solvents, temperatures, and mixtures plays an important role in harnessing its full potential in applications.

Interesting facts

Interesting Facts about 5-(4-methylpiperazin-1-yl)-6H-benzo[b][1]benzothiepin-5-ol

5-(4-methylpiperazin-1-yl)-6H-benzo[b][1]benzothiepin-5-ol is a fascinating compound that belongs to a class of chemicals known as benzothiepins. This compound has garnered attention in the pharmaceutical industry due to its potential therapeutic applications. Here are some intriguing aspects:

  • Pharmacological Potential: The compound exhibits promising activity as a potential treatment for various neurological disorders. Its unique structural features may contribute to its ability to interact with specific neurotransmitter systems in the brain.
  • Structural Complexity: The intricate structure of this compound includes a combination of a benzothiepin core and a piperazine moiety, which adds to its chemical versatility and the potential for diverse reactivity.
  • Base for Drug Development: Researchers are exploring derivatives of this compound in search of more effective pharmacological agents. Its modification can lead to the creation of new compounds with improved efficacy and reduced side effects.
  • Research Interest: Several studies have highlighted the structure-activity relationship (SAR) for this compound, leading to insights that aid in understanding how variations in the molecular structure can impact biological activity.
  • Therapeutic Classification: Compounds like 5-(4-methylpiperazin-1-yl)-6H-benzo[b][1]benzothiepin-5-ol are often investigated for their antidepressant and anxiolytic effects, affirming the role of this chemical class in mental health treatment.

As scientific research continues to evolve, the significance of 5-(4-methylpiperazin-1-yl)-6H-benzo[b][1]benzothiepin-5-ol in medicinal chemistry is likely to grow, highlighting the compound's role in understanding and treating complex health conditions. As noted by a prominent researcher in the field, "The exploration of structural diversity can unveil paths to novel and effective therapeutic agents."