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Trifluoromethylphenyl dihydrooxazolamine

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Identification
Molecular formula
C10H9F3N2O
CAS number
123456-78-9
IUPAC name
5-[4-(trifluoromethyl)phenyl]-4,5-dihydrooxazol-2-amine
State
State

At room temperature, Trifluoromethylphenyl dihydrooxazolamine is typically a solid.

Melting point (Celsius)
98.00
Melting point (Kelvin)
371.15
Boiling point (Celsius)
368.50
Boiling point (Kelvin)
641.70
General information
Molecular weight
216.19g/mol
Molar mass
216.1860g/mol
Density
1.3818g/cm3
Appearence

The compound is typically a crystalline solid that may appear white to off-white in color. These characteristics can depend on the degree of purity and exact physical form (e.g., powder, crystal).

Comment on solubility

Solubility of 5-[4-(trifluoromethyl)phenyl]-4,5-dihydrooxazol-2-amine

The solubility of 5-[4-(trifluoromethyl)phenyl]-4,5-dihydrooxazol-2-amine is influenced by several factors, predominantly its chemical structure. This compound contains a trifluoromethyl group, which can impart significant hydrophobic characteristics, thereby affecting its interaction with solvents. Here are key points to consider:

  • Polarity: The presence of the hydrophobic trifluoromethyl group suggests that this compound may exhibit low solubility in polar solvents such as water.
  • Solvent Compatibility: It may be more soluble in non-polar or moderately polar organic solvents, including chloroform, ethanol, or acetone.
  • Temperature Effects: Solubility can also increase with temperature; thus, heating the solvent may enhance the dissolution process.
  • pH Influence: Since the compound is an amine, its solubility can be affected by changes in pH, which can influence the protonation state of the amine.

In summary, while the precise solubility characteristics of this compound require empirical determination, its structural features suggest that it would be sparingly soluble in water but potentially more soluble in organic solvents. Further experimentation and solubility studies would provide valuable insights into its behavior in various solutions.

Interesting facts

Interesting Facts about 5-[4-(Trifluoromethyl)phenyl]-4,5-dihydrooxazol-2-amine

This intriguing compound, known as 5-[4-(trifluoromethyl)phenyl]-4,5-dihydrooxazol-2-amine, exhibits unique properties and potential applications in the realm of chemistry and pharmaceuticals. Here are some noteworthy aspects:

  • Fluorinated Compounds: The presence of the trifluoromethyl group (–CF3) is significant; it enhances the lipophilicity and metabolic stability of organic molecules, making compounds with this group candidates for development as drugs.
  • Structural Characteristics: The oxazol group (a five-membered ring containing nitrogen and oxygen) is known for its biological activity. Oxazoles are often found in bioactive compounds and can exhibit antimicrobial and anticancer properties.
  • Pharmaceutical Potential: With its distinct structure, this compound may serve as a scaffold in medicinal chemistry, allowing chemists to modify its structure to optimize biological activity. This could lead to new therapeutic agents.
  • Research Applications: Researchers are investigating compounds like this one for their roles in various fields, such as agrochemicals, where they might help in developing new pesticides or herbicides.
  • Recent Studies: A number of studies focus on the effects of fluorination in drug design, where compounds like 5-[4-(trifluoromethyl)phenyl]-4,5-dihydrooxazol-2-amine may offer insights into enhancing efficacy and reducing side effects in pharmacology.

As a final note, understanding the properties and behaviors of compounds like this can pave the way for new discoveries in material science and drug development, highlighting the diverse applications of chemistry in addressing real-world problems.

Synonyms
Fluminorex
720-76-3
MCN-1231
LUO2Z7954T
2-Oxazolamine, 4,5-dihydro-5-(4-(trifluoromethyl)phenyl)-
Fluminorex [USAN:INN]
UNII-LUO2Z7954T
5-[4-(trifluoromethyl)phenyl]-4,5-dihydro-1,3-oxazol-2-amine
FLUMINOREX [INN]
Fluminorex (USAN/INN)
FLUMINOREX [USAN]
SCHEMBL121091
CHEMBL2107247
DTXSID00862387
CHEBI:229862
NMGYDYBWRZHLHR-UHFFFAOYSA-N
AKOS014924798
NS00123794
D04210
Q5462775
2-Amino-5-(alpha,alpha,alpha-trifluoro-p-tolyl)-2-oxazoline
2-Oxazolamine, 4,5-dihydro-5-(4-(trifluoromethyl)-phenyl)-
5-[4-(triluoromethyl)phenyl]-4,5-dihydro-1,3-oxazol-2-amine
2-AMINO-5-(.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-P-TOLYL)-2-OXAZOLINE