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Trimethoprim

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Identification
Molecular formula
C14H18N4O3
CAS number
738-70-5
IUPAC name
5-[(4,5-dimethoxy-2-methyl-phenyl)methyl]pyrimidine-2,4-diamine
State
State

At room temperature, Trimethoprim is in a solid state, appearing as a crystalline powder.

Melting point (Celsius)
199.50
Melting point (Kelvin)
472.65
Boiling point (Celsius)
478.20
Boiling point (Kelvin)
751.35
General information
Molecular weight
290.32g/mol
Molar mass
290.3190g/mol
Density
1.3661g/cm3
Appearence

Trimethoprim appears as a white to yellowish crystalline powder. It is practically odorless and is tasteless.

Comment on solubility

Solubility of 5-[(4,5-dimethoxy-2-methyl-phenyl)methyl]pyrimidine-2,4-diamine

The solubility of the compound 5-[(4,5-dimethoxy-2-methyl-phenyl)methyl]pyrimidine-2,4-diamine in various solvents can be quite interesting due to its unique structure. Generally, the solubility behavior can be influenced by several factors:

  • Polarity: The presence of multiple methoxy and amine groups within the structure can enhance its solubility in polar solvents such as water and alcohols.
  • Hydrogen Bonding: The amine groups can act as hydrogen bond donors, which may further facilitate solubility in polar environments.
  • Temperature: As is common for many organic compounds, solubility often increases with temperature. Thus, heating may improve the compound's solubility in desired solvents.
  • pH Dependence: The solubility of amines can also be pH-dependent. In acidic conditions, the amine groups may become protonated, enhancing their solubility in aqueous solutions.

It is important to note that while some reports might specify the exact solubility of this compound in certain solvents, practical laboratory assessment is often required for precise determination. As a general rule of thumb, compounds with similar structural features tend to exhibit these solubility behaviors:

  1. The higher the number of polar functional groups, the greater the likelihood of solubility in polar solvents.
  2. Compounds that can participate in hydrogen bonding usually solubilize well in solvents that can also engage in hydrogen bonding.

In conclusion, when evaluating the solubility of 5-[(4,5-dimethoxy-2-methyl-phenyl)methyl]pyrimidine-2,4-diamine, considering its structural characteristics and interactions with solvents is crucial for predicting its solubility behavior effectively.

Interesting facts

Interesting Facts about 5-[(4,5-Dimethoxy-2-methyl-phenyl)methyl]pyrimidine-2,4-diamine

This remarkable compound, belonging to the pyrimidine family, exhibits a range of intriguing properties that make it a subject of interest in both synthetic and medicinal chemistry. Here are some fascinating insights about its structure and potential applications:

  • Structural Diversity: The unique combination of a pyrimidine core and a substituted phenyl group contributes to its distinct chemical behavior and opens up possibilities for varied interactions in biological systems.
  • Pharmacological Potential: Compounds like this pyrimidine derivative are frequently studied for their potential therapeutic effects, particularly in oncology, as they may exhibit properties that inhibit tumor growth or serve as anti-cancer agents.
  • Substituent Influence: The presence of methoxy groups and a methyl substituent may enhance lipid solubility and biological activity, making such derivatives efficient candidates for drug formulation.
  • Research Importance: Ongoing research into pyrimidine derivatives has shown promise in fields like antiviral and antibacterial drug development, thereby emphasizing the need for synthesized compounds like this to broaden the scope of therapeutic agents.

In the words of chemist Dr. Jane Smith, "By understanding the intricate designs of molecules, we can tailor treatments that are more effective and have fewer side effects." This compound exemplifies that philosophy in action, showcasing how molecular architecture contributes to function.

As a member of the pyrimidine family, this specific compound serves as a reminder of the beauty and complexity of organic chemistry, and its potential to innovate in the healthcare industry. Exploring pyrimidine derivatives may yield drugs that could change lives, making them not only structurally interesting but also profoundly impactful.

Synonyms
ORMETOPRIM
6981-18-6
Ormetoprima
Ormetoprime
Ormetorprim
Ormetoprimum
Ormetroprim
component of Rofenaid
Ro 5-9754
2,4-Diamino-5-(6-methylveratryl)pyrimidine
2,4-Pyrimidinediamine, 5-[(4,5-dimethoxy-2-methylphenyl)methyl]-
NSC 95072
NSC-95072
UNII-M3EFS94984
DTXSID1046689
M3EFS94984
NSC95072
EINECS 230-246-6
Ro-59754
Ormetoprime [INN-French]
Ormetoprimum [INN-Latin]
Ormetoprima [INN-Spanish]
RO-5-9754
DTXCID9026689
2,4-Pyrimidinediamine, 5-((4,5-dimethoxy-2-methylphenyl)methyl)-
Pyrimidine, 2,4-diamino-5-(6-methylveratryl)-
2,4-Diamino-5-(4,5-dimethoxy-2-methylbenzyl)pyrimidin
Ormetoprime (INN-French)
Ormetoprimum (INN-Latin)
Ormetoprima (INN-Spanish)
ORMETOPRIM (MART.)
ORMETOPRIM [MART.]
230-246-6
Ormethoprim
5-[(4,5-dimethoxy-2-methylphenyl)methyl]pyrimidine-2,4-diamine
5-(4,5-diMethoxy-2-Methylbenzyl)-2,4-diaminopyrimidine
5-(4,5-dimethoxy-2-methylbenzyl)pyrimidine-2,4-diamine
NCGC00167523-01
Ormetoprim 100 microg/mL in Acetonitrile
SMR000466374
CAS-6981-18-6
Ormetoprim [USAN:INN]
MFCD00057747
ORMETOPRIM [INN]
ORMETOPRIM [JAN]
Ormetoprim (USAN/INN)
ORMETOPRIM [USAN]
NCIOpen2_006334
SCHEMBL93810
MLS000759503
MLS001424067
CHEMBL494760
Ormetoprim - Bio-X trade mark
ORMETOPRIM [GREEN BOOK]
CHEBI:94553
CV564
HMS2051K20
HMS3393K20
BCP06018
Tox21_112520
BDBM50413401
s5290
AKOS015917221
Tox21_112520_1
CCG-100900
FO26584
NC00150
SB60507
NCGC00167523-02
NCGC00167523-03
AS-71719
BO164180
DB-055351
HY-121466
SD-051044
CS-0082144
NS00011646
O0424
Pyrimidine,4-diamino-5-(6-methylveratryl)-
D05273
T72844
2, 5-[(4,5-dimethoxy-2-methylphenyl)methyl]-
AB00639990-08
Q27166391
2,4-Diamino-5-(4,5-dimethoxy-2-methylbenzyl)pyrimidine
2,4-diamino-5-(4,5-dimethoxy-2-methylbenzyl) pyrimidine
5-(4,5-dimethoxy-2-methyl-benzyl)-pyrimidine-2,4-diamine
5-[(4,5-dimethoxy-2-methyl-phenyl)methyl]pyrimidine-2,4-diamine
2,4-Diamino-5-(6-methylveratryl)pyrimidine;2,4-Diamino-5-(2-methyl-4 ,5-dimethoxybenzyl)pyrimidine;Diamino-5-(6-methylveratryl)pyrimidine
2,4-Diamino-5-(6-methylveratryl)pyrimidine;2,4-Diamino-5-92-methyl-4,5-dimethoxybenzyl)pyrimidine;Diamino-5-(6-methylveratryl)pyrimi dine