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Furazolidone

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Identification
Molecular formula
C8H7N3O5
CAS number
67-45-8
IUPAC name
5-(5-nitro-2-furyl)-3H-1,3,4-oxadiazol-2-one
State
State

Furazolidone is typically found in the solid state at room temperature. It is a crystalline, stable powder under normal conditions. The solid state allows it to be easily formulated into tablets or powders for pharmaceutical applications.

Melting point (Celsius)
259.00
Melting point (Kelvin)
532.15
Boiling point (Celsius)
275.00
Boiling point (Kelvin)
548.15
General information
Molecular weight
225.16g/mol
Molar mass
225.1570g/mol
Density
1.4900g/cm3
Appearence

Furazolidone appears as a yellow, crystalline powder. The color is a characteristic feature due to the presence of its nitrofuran structural component. It is typically odorless or may have a slight odor characteristic of nitro compounds.

Comment on solubility

Solubility of 5-(5-nitro-2-furyl)-3H-1,3,4-oxadiazol-2-one

5-(5-nitro-2-furyl)-3H-1,3,4-oxadiazol-2-one is a unique compound with distinct solubility characteristics. Understanding its solubility profile is essential for practical applications and research. Here are some key points to consider:

  • Solvent Compatibility: This compound exhibits variable solubility in different solvents, commonly showing better solubility in polar organic solvents such as dimethyl sulfoxide (DMSO) or dimethylformamide (DMF).
  • Temperature Dependence: The solubility can be significantly influenced by temperature; typically, solubility increases with rising temperatures, which is standard behavior for most organic compounds.
  • pH Sensitivity: As a heterocyclic compound, its solubility might also be affected by the pH of the solution, displaying increased solubility in alkaline conditions.
  • Crystal Structure: The crystalline nature of the compound can impact its solubility, where more amorphous forms tend to dissolve more readily than their crystalline counterparts.

In summary, the solubility of 5-(5-nitro-2-furyl)-3H-1,3,4-oxadiazol-2-one is influenced by a combination of factors including solvent choice, temperature, pH, and physical state. Understanding how these elements interplay enables better utilization in various chemical processes and applications.

Interesting facts

Interesting Facts about 5-(5-nitro-2-furyl)-3H-1,3,4-oxadiazol-2-one

5-(5-nitro-2-furyl)-3H-1,3,4-oxadiazol-2-one is a fascinating compound with a variety of properties and applications. Here are some key points about this intriguing compound:

  • Structural Significance: The compound features a unique oxadiazole ring, which is known for its potential in various chemical reactions and applications.
  • Biological Activity: Compounds that contain a nitrofuryl group often exhibit interesting biological activities. Research into related compounds has indicated potential pharmacological properties, making this compound a candidate for further investigation in medicinal chemistry.
  • Applications in Research: This compound may serve as a valuable intermediate in the synthesis of more complex molecules, highlighting the importance of oxadiazoles in organic synthesis.
  • Interesting Reactivity: The presence of both nitro and oxadiazole functionalities can lead to various reactivity patterns, making it a subject of interest for chemists exploring new pathways for chemical transformations.

In summary, 5-(5-nitro-2-furyl)-3H-1,3,4-oxadiazol-2-one stands out due to its distinctive structural features and potential applications in both biological studies and synthetic chemistry.

Synonyms
2122-86-3
5-(5-Nitro-2-furyl)-1,3,4-oxadiazole-2-ol
DTXSID5020948
NSC 25249
BRN 0533794
DTXCID10948
AI3-52123
1,3,4-Oxadiazol-2(3H)-one, 5-(5-nitro-2-furanyl)-
1,3,4-OXADIAZOLE-2-OL, 5-(5-NITRO-2-FURYL)-
delta2-1,3,4-Oxadiazolin-5-one, 2-(5-nitro-2-furyl)-
delta2-1,3,4-Oxadiazolin-5-one, 2-(5-nitro-2-furyl)-(8CI)
633-649-9
5-(5-nitrofuran-2-yl)-3H-1,3,4-oxadiazol-2-one
NSC-25249
NSC25249
JR2H6CR3KP
5-(5-nitro-2-furyl)-1,3,4-oxadiazol-2-ol
5-(5-nitrofuran-2-yl)-1,3,4-oxadiazol-2-ol
5-(5-Nitro-2-furyl)-1,3,4-oxadiazol-2(3H)-one
CHEMBL259187
1,3,4-Oxadiazol-2(3H)-one,5-(5-nitro-2-furanyl)-
5-(5-NITRO-2-FURYL)-1,3,4-OXADIAZOL-2-ONE
Tox21_301880
AKOS013513975
NCGC00255379-01
WLN: T5OJ BNW E- CT5NN DOJ EQ
CAS-2122-86-3
DS-002763
1,4-Oxadiazole-2-ol, 5-(5-nitro-2-furyl)-
5-(5-nitro-2-furyl)-1,3,4-oxadi-azole-2-ol
Nitro-2-furyl)-1,3,4-oxadiazole-2-ol, 5-(5-
1,4-Oxadiazol-2(3H)-one, 5-(5-nitro-2-furanyl)-
5-(5-Nitro-2-furanyl)-1,3,4-oxadiazol-2(3H)-one
5-(5-Nitrofuran-2-yl)-1,3,4-oxadiazol-2(3H)-one
.DELTA.2-1,4-Oxadiazolin-5-one, 2-(5-nitro-2-furyl)-