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NADP+

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Identification
Molecular formula
C21H29N7O17P3
CAS number
53-59-8
IUPAC name
[5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-[[hydroxy(phosphonooxy)phosphoryl]methyl]phosphinic acid
State
State

At room temperature, NADP+ is typically found as a solid. It is commercially available as a crystalline powder, which is stable under normal conditions.

Melting point (Celsius)
140.00
Melting point (Kelvin)
413.15
Boiling point (Celsius)
100.00
Boiling point (Kelvin)
373.15
General information
Molecular weight
745.42g/mol
Molar mass
745.4150g/mol
Density
1.8200g/cm3
Appearence

NADP+ (Nicotinamide adenine dinucleotide phosphate) typically appears as a white to off-white crystalline powder. However, as it often exists in the form of its sodium salt when used in biochemical applications, it might also be available as a colorless or white powder depending on its state of hydration and salt form.

Comment on solubility

Solubility Characteristics of [5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-[[hydroxy(phosphonooxy)phosphoryl]methyl]phosphinic acid

The solubility of the compound C21H29N7O17P3, which features a complex structure, can vary significantly based on several factors.

Factors Influencing Solubility

  • Polarity: The presence of multiple hydroxyl (-OH) and phosphonic acid groups contributes to the compound's polar character, which typically enhances solubility in polar solvents such as water.
  • pH Levels: The solubility may be affected by the pH of the solution. An increase in pH can deprotonate phosphonic acid groups, possibly enhancing solubility.
  • Temperature: Higher temperatures generally increase solubility, enabling greater molecular interaction in solution.

As such, one might observe:

  • A notable solubility in aqueous environments given the presence of hydrophilic groups.
  • Limited solubility in organic solvents, as nonpolar environments may fail to stabilize the compound's structure.

In conclusion, the solubility profile of this compound is not just a simple yes or no; it reflects a delicate balance influenced by its intricate chemical structure and the surrounding environmental conditions. In the words of chemists, "Succeeding in solubility often requires navigating the nuances of molecular interaction." This emphasizes the intricate interplay of structural and environmental factors affecting the solubility of complex molecules.

Interesting facts

Interesting Facts About 5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-[[hydroxy(phosphonooxy)phosphoryl]methyl]phosphinic acid

This intriguing compound, often referred to as a phosphoryl analog, plays a significant role in the realm of biochemistry and nucleotide metabolism. Here are some fascinating insights into its features and significance:

  • Biochemical Relevance: This compound is structurally related to nucleotides and has been studied for its potential interactions with specific enzymes involved in nucleotide synthesis and metabolism.
  • Amino Group Influence: The presence of the 6-aminopurine component suggests that this compound could participate in various biological processes, potentially modulating cellular functions or pathways.
  • Phosphonate Characteristics: As a phosphonic acid derivative, it is important in research for its usage as a phosphorylating agent, which can impact energy transfer processes in cells.
  • Drug Development: Given its complex structure, the compound is being investigated for pharmaceutical applications, particularly concerning antiviral and anticancer therapies.
  • Analytical Chemistry: This compound is a subject of interest in analytical chemistry, where methods like NMR and HPLC are employed to study its properties and behaviors in various chemical environments.

In quotes by researchers studying this kind of compound, one might hear, "Understanding the subtleties of nucleobase modifications can lead to major breakthroughs in drug design." This is a reflection of the growing recognition of how exerting control over nucleotide derivatives can reshape our approach to therapeutic interventions.

Thus, the study of 5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-[[hydroxy(phosphonooxy)phosphoryl]methyl]phosphinic acid truly embodies the intersection of organic chemistry, biochemistry, and pharmacology, revealing the endless possibilities offered by complex molecular architectures.

Synonyms
ATP, alpha, beta methylene
BDBM50026203
DB-089892
({[({[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)methyl](hydroxy)phosphoryl}oxy)phosphonic acid