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NADH

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Identification
Molecular formula
C21H27N7O14P2
CAS number
606-68-8
IUPAC name
[[5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] [5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphate
State
State

At room temperature, NADH is typically in a solid state as a crystalline powder.

Melting point (Celsius)
160.00
Melting point (Kelvin)
433.00
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.00
General information
Molecular weight
663.43g/mol
Molar mass
663.4250g/mol
Density
1.4600g/cm3
Appearence

NADH typically appears as a white or near-white crystalline powder. It is sensitive to light and moisture, and it should be handled under inert atmosphere conditions to maintain stability.

Comment on solubility

Solubility of [5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] [5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphate

The compound with the formula C21H27N7O14P2 presents an intriguing profile when it comes to its solubility characteristics. Solubility can significantly influence a compound's bioavailability, distribution, and overall efficacy. Here are some key points to consider regarding its solubility:

  • Polarity: The presence of multiple hydroxyl (-OH) and phosphate groups in the structure typically suggests that the compound is likely to be water-soluble. The polar nature of these functional groups can enhance interactions with water molecules.
  • pH Dependence: The solubility may vary with pH. Given the potential for the organism to protonate the nitrogens in the pyridinium and purine moieties, the compound's solubility could indeed be higher in acidic conditions.
  • Gel Formation: In some instances, compounds with high hydroxyl content can form gels at higher concentrations, which may further modify their solubility profile under certain conditions.
  • Interaction with Ionic Species: Being a phosphate ester, the compound may show affinity for cations, particularly under physiological conditions, which could affect its overall solubility.

Overall, while predicting the solubility of this complex compound can be challenging, it can be anticipated that the combination of its polar functional groups and specific structural characteristics may lend it a favorable solubility profile. Conducting further experimental assessments would elucidate its precise solubility behavior in different environments.

Interesting facts

Exploring the Unique Properties of a Complex Phosphate Compound

This intricate compound, a member of the class of phosphorylated adenosine derivatives, features a fascinating blend of biological and chemical significance. It embodies complex justifications for its structure, consisting of multiple functional groups that confer unique characteristics:

  • Amino Purine Moiety: The incorporation of a 6-aminopurine group highlights its connection to nucleobases, which are critical in DNA and RNA function.
  • Tetrahydrofuran Structure: The presence of the tetrahydrofuran ring contributes to the overall cyclic stability of the compound, making it noteworthy for its potential biochemical interactions.
  • Hydroxy Groups: These groups enhance the reactivity and solubility of the compound, which is important for its role in various biological processes.
  • Phosphate Functionality: The phosphate groups are essential for energy transfer and signal transduction within cells, marking this compound as potentially vital for understanding metabolic pathways.

This compound serves as an exemplary model for scientific studies focused on:

  • **Biological Activity**: Investigating how such depsipeptides influence cellular mechanisms.
  • **Drug Development**: Exploring its applications in pharmaceutical chemistry, especially concerning antibacterial or anticancer activities.
  • **Understanding Enzyme Interactions**: Researchers can utilize this compound to study how enzymes might interact with phosphorylated substrates.

In addition, the interplay of structural motifs present in this compound may foster exciting biochemical applications. As the biochemistry field continues to expand, compounds like this are pivotal. They bridge foundational science with innovative therapeutic approaches, reminding us of the endless possibilities chemistry holds.

In the words of a chemistry student: "Understanding the complexities of such compounds is not just about memorizing structures; it's about uncovering the *stories* behind them and their roles in life's many processes."


Synonyms
Endopride
alpha-Diphosphopyridine nucleotide
beta-DPN;beta-NAD;beta-Nicotinamide Adenine Dinucleotide
b-Nicotinamide adenine dinucleotide
NSC20272
SCHEMBL4363695
SCHEMBL25792097
BCP21324
STL453130
AKOS026750156
DA-35035
SY076105
DB-055710
A11563
Adenosine 5'-(trihydrogen diphosphate), hydroxide, inner salt
3-Carbamoyl-1.beta.-D-ribofuranosylpyridinium hydroxide, inner salt
a-Nicotinamide adenine dinucleotide from Saccharomyces cerevisiae
1-[(2R,3R,4S,5R)-5-{[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl phosphonato)oxy]methyl}-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda-pyridin-1-ylium