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NAD+

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Identification
Molecular formula
C21H27N7O14P2
CAS number
53-84-9
IUPAC name
[[5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] [5-[3-carbamoyl-4-(1-methyl-2-oxo-butyl)pyridin-1-ium-1-yl]-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphate
State
State

At room temperature, NAD+ is in a solid state. It is stable under normal conditions but should be stored in a cool, dry place to maintain its efficacy and stability.

Melting point (Celsius)
140.00
Melting point (Kelvin)
413.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
663.43g/mol
Molar mass
663.4250g/mol
Density
1.4780g/cm3
Appearence

NAD+ (Nicotinamide adenine dinucleotide) appears as a white to off-white powder. It is hygroscopic in nature and can be visibly crystalline. The compound is typically stable when kept dry and in a sealed container.

Comment on solubility

Solubility of [5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] [5-[3-carbamoyl-4-(1-methyl-2-oxo-butyl)pyridin-1-ium-1-yl]-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphate: C21H27N7O14P2

The solubility characteristics of this complex compound are of particular interest due to its multifaceted structure. The solubility can generally be influenced by a variety of factors:

  • Polarity: The presence of multiple hydroxyl (-OH) and phosphate (-PO4H2) groups generally enhances the solubility in polar solvents, such as water.
  • Hydrophobic components: The incorporation of hydrophobic moieties, such as the pyridin-1-ium and alkyl groups, may contribute to limited solubility in non-polar solvents.
  • Ionization: Under physiological conditions, the ionic character of the compound could play a significant role, affecting its bioavailability and solubility in biological systems.

Overall, while one might expect a degree of solubility in aqueous environments due to hydrophilic functional groups, it is also essential to consider the potential for precipitation or aggregation resulting from the balance of hydrophilic and hydrophobic regions. Thus, understanding its solubility is critical for applications in pharmaceuticals and material science.

Interesting facts

Interesting Facts about [5-(6-Aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] [5-[3-carbamoyl-4-(1-methyl-2-oxo-butyl)pyridin-1-ium-1-yl]-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphate

This compound is a fascinating example of a complex organic molecule that showcases the intricate relationship between pharmacology and biochemistry. Here are some intriguing aspects:

  • Structural Complexity: The compound features a unique combination of a tetracyclic structure with multiple functional groups that include amino, hydroxyl, and phosphate moieties. This complexity gives it potential biological significance.
  • Potential Therapeutic Uses: The presence of nucleobase-like structures suggests that this compound could play a role in medicinal chemistry, particularly in developing antiviral or anticancer drugs, as compounds with similar structures have demonstrated such activities in studies.
  • Bioactivity: Certain derivatives related to this compound have been studied for their ability to inhibit specific enzymes or pathways, contributing to their effectiveness in combating diseases linked to abnormal cellular processes.
  • Phosphorylation: The phosphoryl group in the chemical can enhance solubility and bioavailability, which are critical parameters for drug efficacy in biological systems. Phosphorylated compounds often exhibit greater biological activity.
  • Research and Development: Ongoing research into this compound could lead to significant advances in understanding cellular mechanisms, given its structural similarities to naturally occurring nucleotides and their metabolites.

In the words of renowned chemist Robert H. Grubbs, "Chemistry is the study of transformations." This compound embodies this philosophy as it has the potential to facilitate numerous transformations in the realm of health and disease management.

As a compound rich in elements that can interact with biological systems, the study of this molecule could provide insights that transcend typical chemical boundaries, thereby bridging the gap between chemistry and life sciences.