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NADP+

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Identification
Molecular formula
C21H29N7O17P3
CAS number
53-59-8
IUPAC name
[[5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] [5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl hydrogen phosphate
State
State

At room temperature, NADP+ is typically encountered as a dry crystalline solid. It is stable under normal conditions and is commonly stored as a solid until needed for biological or chemical assays.

Melting point (Celsius)
200.00
Melting point (Kelvin)
473.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
743.40g/mol
Molar mass
743.4040g/mol
Density
1.2502g/cm3
Appearence

NADP+ typically appears as a crystalline powder when isolated. It is often sold as a salt for laboratory purposes and appears as a fine white or off-white powder.

Comment on solubility

Solubility of [5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] [5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl hydrogen phosphate (C21H29N7O17P3)

The solubility of this complex compound is a critical consideration in its applications. Understanding its solubility can provide insight into its behavior in various environments. Here are some key points to consider:

  • Water Solubility: The presence of multiple hydroxyl groups suggests that the compound may exhibit significant solubility in water, enhancing its potential bioavailability.
  • Solvent Interactions: It may dissolve readily in polar solvents, but show limited solubility in nonpolar solvents due to the hydrophilic characteristics imparted by its functional groups.
  • pH Dependency: The solubility might vary depending on the pH level of the solution, given that phosphates can be influenced by protonation and deprotonation reactions.
  • Temperature Effects: Like many chemical compounds, an increase in temperature could enhance solubility, allowing for better dispersion in solutions.

In summary, the solubility of this compound is likely varied and influenced by the surrounding environment. It is essential to evaluate solubility in specific solvents and conditions to utilize this compound effectively in practical applications.

Interesting facts

Interesting Facts about 5-(6-Aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] [5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl hydrogen phosphate

This complex chemical compound is a testament to the intricate relationships between molecular structure and biological function. Here are some fascinating insights:

  • Biochemical Significance: Compounds of this type are often involved in cellular signaling and may play roles in important biochemical processes, such as nucleotide metabolism.
  • Phosphorylation: The presence of the phosphate group in this compound suggests it could be significant in energy transfer and storage, akin to ATP's role in cellular energy dynamics.
  • Design Complexity: The structural design indicates a potential for diverse biological activities due to the synergy of the tetrahydrofuran ring and the various functional groups present.
  • Medicinal Potential: Given the incorporation of nitrogenous bases and pyridine-like structures, this compound warrants investigation for possible applications in drug design, particularly in cancer therapy or antiviral treatments.

Scientists conducting research in the field of medicinal chemistry may be particularly interested in the following:

  • How alterations in the molecular structure can influence pharmacological properties
  • The exploration of its interactions with biological targets (e.g., enzymes or receptors)
  • Its stability and behavior in biological systems, which is crucial for determining safety and efficacy

In summary, the dual presence of the tetrahydrofuran moiety and the phosphoryl functional groups renders this compound not only interesting from a theoretical point of view but also opens doors for practical applications in pharmacology. As researchers continue to explore such compounds, we may uncover novel therapeutic avenues that can significantly impact human health.

Synonyms
Dihydronicotinamide formycin dinucleotide
74927-11-0
[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
Dihydronicotinamide-adenine dinucleotide
D-Ribitol, 1-C-(7-amino-1H-pyrazolo(4,3-d)pyrimidin-3-yl)-1,4-anhydro-, 5-(trihydrogen diphosphate), 5-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide, (S)-
((5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl)methoxy-hydroxyphosphoryl) (5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl)methyl hydrogen phosphate
NFDH
CERAPP_26258
SCHEMBL12253377
SCHEMBL20208004
SCHEMBL25792100
DTXSID20861594
dihydronicotinamide adenine dinu-cleotide
NS00041065