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Deoxyadenosine triphosphate (dATP)

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Identification
Molecular formula
C10H16N5O12P3
CAS number
1927-31-7
IUPAC name
[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] [3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] hydrogen phosphate
State
State

dATP is typically found as a solid at room temperature. Due to its hygroscopic nature, it can also become slightly sticky or clumped if exposed to air or moisture.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
273.15
General information
Molecular weight
491.18g/mol
Molar mass
491.1820g/mol
Density
1.3270g/cm3
Appearence

Deoxyadenosine triphosphate (dATP) appears as a white crystalline powder. It is hygroscopic in nature, meaning it can absorb moisture from the air, which causes it to clump together. Therefore, it is often stored in an anhydrous state to maintain stability.

Comment on solubility

Solubility of the Compound

The solubility of the compound [5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] [3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] hydrogen phosphate (C10H16N5O12P3) can be described as follows:

  • Water Solubility: The presence of multiple hydroxyl (-OH) groups and phosphate groups in the structure generally indicates a tendency for good solubility in polar solvents such as water. The hydrophilicity associated with these functional groups enhances interactions with water molecules.
  • Solvent Compatibility: This compound may exhibit variable solubility in organic solvents. Common organic solvents such as ethanol, methanol, or dimethyl sulfoxide (DMSO) might be suitable for dissolving this compound, particularly due to its amphiphilic character.
  • Influence of pH: The solubility could also be significantly influenced by pH levels. Changes in pH can alter the ionization state of the phosphate groups, which might either enhance or diminish solubility in aqueous environments.
  • Temperature Effects: Typically, increasing the temperature may enhance solubility, allowing for a better dissolution of the compound. However, specific behavior should be validated with experimental studies.

In summary, the solubility properties of this compound are likely dominated by the presence of hydrophilic groups, enabling solubility in polar solvents and potentially allowing for variable solubility depending on environmental conditions. As stated, "the more complex the molecule, the more interesting its solubility characteristics." Experimentation is crucial to fully understand and utilize this compound's solubility in practical applications.

Interesting facts

Interesting Facts about the Compound

This compound, with its complex structure, embodies fascinating aspects relevant to both chemistry and biochemistry. Understanding its components can provide insight into its potential applications and behavior.

Key Characteristics

  • Functional Groups: The compound contains numerous functional groups, including hydroxyl, amino, and phosphonate groups, which contribute to its reactivity and biological significance.
  • Biological Relevance: Given its structure, it's likely to play roles in biochemical pathways, especially in nucleic acid metabolism, and could be a target for drug design.
  • Phosphorylation Processes: The presence of phosphorus in the form of phosphoryl suggests implications in energy transfer and signaling within biological systems.

As a scientist or student delving into this compound, consider these intriguing connections:


  • It is structurally related to purine nucleosides, indicating potential interactions with DNA and RNA.
  • The compound's complex shape might allow for unique binding interactions, making it a candidate for pharmaceutical research.
  • Its synthesis could provide insights into modern organic synthesis techniques and strategies to control stereochemistry.

In the study of this versatile molecule, one might remember the words of a renowned chemist: "Simplicity is the ultimate sophistication." The intricate nature of this compound challenges us to uncover its underlying simplicity, ultimately leading to significant discoveries.

Synonyms
[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] hydrogen phosphate
31416-98-5
85-61-0
NSC20274
SCHEMBL26753
DTXSID00859136
S00343a
4-(((((((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)-2-hydroxy-N-((Z)-3-hydroxy-3-((2-mercaptoethyl)imino)propyl)-3,3-dimethylbutanimidic acid
MFCD00065465
NSC-20274
SY225369
NS00013541
[5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methyl 3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl dihydrogen diphosphate