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Fosfomycin

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Identification
Molecular formula
C3H7O4PS2
CAS number
23155-02-4
IUPAC name
[5-acetamido-4-hydroxy-6-(1,2,3-trihydroxypropyl)tetrahydropyran-2-yl]phosphonic acid
State
State

Fosfomycin is a solid at room temperature. It is used in medication formulations as a powder to be dissolved in water before ingestion or as a coated tablet. Its stable state ensures durability and ease of transport and formulation in the pharmaceutical industry.

Melting point (Celsius)
102.00
Melting point (Kelvin)
375.15
Boiling point (Celsius)
432.00
Boiling point (Kelvin)
705.15
General information
Molecular weight
138.06g/mol
Molar mass
138.0590g/mol
Density
1.9000g/cm3
Appearence

Fosfomycin, in its pure form, typically appears as a white crystalline powder. It is highly soluble in water, which aids in its formulation for medical use. The powder is often used to make oral medications, most commonly in the form of a powder or granules for oral solution. It may absorb moisture from the air (hygroscopic) and thus is typically stored in airtight containers.

Comment on solubility

Solubility of [5-acetamido-4-hydroxy-6-(1,2,3-trihydroxypropyl)tetrahydropyran-2-yl]phosphonic acid

The compound [5-acetamido-4-hydroxy-6-(1,2,3-trihydroxypropyl)tetrahydropyran-2-yl]phosphonic acid, with the chemical formula C3H7O4PS2, exhibits unique solubility characteristics that are crucial for its applications. Understanding its solubility can provide insights into its behavior in various environments, including biological systems.

Key Solubility Insights:

  • Aqueous Solubility: Due to its phosphonic acid group, this compound is expected to have decent solubility in water, facilitating interactions in physiological conditions.
  • pH Sensitivity: The solubility may vary with pH levels. In more acidic conditions, it could potentially achieve a higher degree of protonation, enhancing its stability and solubility.
  • Interactions with Other Compounds: Its structure suggests the potential for hydrogen bonding, which could improve solubility in polar solvents.
  • Limitations: On the other hand, hydrophobic moieties may lead to reduced solubility in non-polar solvents, limiting its utility in certain applications.

As one can see, the solubility of [5-acetamido-4-hydroxy-6-(1,2,3-trihydroxypropyl)tetrahydropyran-2-yl]phosphonic acid is influenced by its functional groups, making it an intriguing subject for further study. Additionally, understanding these solubility properties can assist in optimizing formulations in pharmaceuticals and material sciences.

Interesting facts

Interesting Facts about [5-acetamido-4-hydroxy-6-(1,2,3-trihydroxypropyl)tetrahydropyran-2-yl]phosphonic acid

[5-acetamido-4-hydroxy-6-(1,2,3-trihydroxypropyl)tetrahydropyran-2-yl]phosphonic acid is a fascinating compound with a rich chemical structure and potential applications in various fields. This compound is a derivative of tetrahydropyran and showcases the interplay between different functional groups, which adds to its versatility:

  • Phosphonic Acid Motif: The phosphonic acid functional group is recognized for its ability to form strong bonds with biological molecules, making it a valuable building block in pharmaceuticals and agrochemicals.
  • Hydroxyl Groups: The presence of multiple hydroxyl groups contributes to its solubility and reactivity, allowing for diverse interactions with other chemical entities.
  • Acetamido Group: The acetamido group not only enhances the compound's stability but also plays a role in mimicking natural substrates in enzyme-catalyzed reactions.

This compound is of particular interest due to its potential applications in medicinal chemistry. It is vital to understand how its unique structure may impact:

  • Biological interactions: The intricate balance of functional groups could influence how [5-acetamido-4-hydroxy-6-(1,2,3-trihydroxypropyl)tetrahydropyran-2-yl]phosphonic acid interacts with biological targets, such as proteins and enzymes.
  • Chemical reactivity: The specific arrangement of chemical moieties may allow for unique reactivity patterns that could be harnessed in synthetic methodologies.
  • Pharmacological properties: Investigating its effects on metabolic processes may reveal promising therapeutic avenues, particularly in treating metabolic disorders.

Although research on this compound is still ongoing, its sophisticated structure and the underpinning chemistry suggest that it could pave the way for innovations in drug development and materials science. As with many such compounds, continuous exploration will help in unlocking its full potential, illustrating the ever-evolving nature of chemical science.

Synonyms
CHEMBL1161587
PD039714