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Thiopental

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Identification
Molecular formula
C11H18N2O2S
CAS number
76-75-5
IUPAC name
5-allyl-5-(1-methylbut-2-ynyl)-2-sulfanyl-1H-pyrimidine-4,6-dione
State
State

At room temperature, Thiopental is typically found as a crystalline solid. It's used in solution form as a rapid-onset short-acting anaesthetic when diluted in water or saline.

Melting point (Celsius)
162.00
Melting point (Kelvin)
435.15
Boiling point (Celsius)
370.00
Boiling point (Kelvin)
643.15
General information
Molecular weight
264.33g/mol
Molar mass
264.3300g/mol
Density
1.4130g/cm3
Appearence

Thiopental is a yellow-tinged, crystalline solid, typically in a powdered form. It has an odor that is somewhat sulfurous, reflective of its thioketone group. When exposed to air, it can absorb moisture and become clumpy.

Comment on solubility

Solubility of 5-allyl-5-(1-methylbut-2-ynyl)-2-sulfanyl-1H-pyrimidine-4,6-dione

The solubility of 5-allyl-5-(1-methylbut-2-ynyl)-2-sulfanyl-1H-pyrimidine-4,6-dione is influenced by several factors, primarily its chemical structure and polarity. Generally, compounds like this pyrimidine derivative exhibit variable solubility depending on the solvent environment. Here are a few key points regarding its solubility:

  • Polarity: The presence of the -S (sulfanyl) group and modifications on the pyrimidine ring can affect its overall solubility. Polar solvents may enhance solubility due to the potential for hydrogen bonding.
  • Solvent Compatibility: This compound is likely more soluble in organic solvents, such as dimethyl sulfoxide (DMSO) or ethanol, compared to water. It is essential to test multiple solvents to identify the best solubility conditions.
  • Concentration Dependence: As with many complex organic molecules, solubility can significantly vary with concentration. A higher concentration might lead to precipitation, whereas diluting the compound may enhance dissolved state.

In conclusion, while specific solubility data is not extensively reported for this particular compound, understanding its chemical functionality allows scientists to predict its behavior in various solvent systems. As always, it’s prudent to conduct empirical solubility tests to conclude the solubility profile accurately.

Interesting facts

Exploring 5-allyl-5-(1-methylbut-2-ynyl)-2-sulfanyl-1H-pyrimidine-4,6-dione

The compound 5-allyl-5-(1-methylbut-2-ynyl)-2-sulfanyl-1H-pyrimidine-4,6-dione belongs to a fascinating class of organic molecules with significant biochemical implications. Here are some intriguing facts about it:

  • Unique Structural Features: This compound features a pyrimidine ring, a crucial component in many biological structures, particularly nucleotides and nucleic acids. The presence of a sulfanyl (–SH) group further diversifies its chemical behavior.
  • Allylic and Alkynyl Substituents: The incorporation of both an allyl and an alkyne group not only makes the structure more complex but also enhances its reactivity. This design enables it to participate in a range of chemical reactions such as electrophilic substitutions and addition reactions, which are pivotal in organic synthesis.
  • Potential Pharmacological Applications: Compounds containing pyrimidine moieties are known to exhibit a variety of biological activities. Research suggests that similar structures could act as antitumor, antiviral, or antimicrobial agents, inspiring scientists to investigate the pharmacological potential of this compound.
  • Synthetic Versatility: The synthesis of this compound involves careful consideration of reaction conditions to safeguard functional groups while promoting the desired transformations. This aspect makes it a valuable candidate for organic chemists aiming to explore synthetic methodologies.
  • Importance in Biochemistry: By studying compounds like this, researchers can gain insights into the mechanisms of enzyme action and the structure-activity relationships of nucleobase analogs, contributing to advances in drug design and development.

In conclusion, 5-allyl-5-(1-methylbut-2-ynyl)-2-sulfanyl-1H-pyrimidine-4,6-dione serves as a prime example of how complex organic molecules can lead to significant advancements in both chemistry and medicine. As quoted by renowned chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." This encapsulates the spirit of exploration that surrounds the study of such compounds.