Skip to main content

Phenobarbital

ADVERTISEMENT
Identification
Molecular formula
C12H12N2O3
CAS number
50-06-6
IUPAC name
5-allyl-5-(2-hydroxypropyl)-1-phenyl-hexahydropyrimidine-2,4,6-trione
State
State

At room temperature, phenobarbital is a crystalline solid. The physical state is typically described as solid and is stable under normal conditions.

Melting point (Celsius)
175.00
Melting point (Kelvin)
448.15
Boiling point (Celsius)
280.00
Boiling point (Kelvin)
553.15
General information
Molecular weight
232.25g/mol
Molar mass
232.2490g/mol
Density
1.1000g/cm3
Appearence

Phenobarbital typically appears as a white crystalline powder. The compound is odorless and can be sweet in taste. The crystals are generally needle-like.

Comment on solubility

Solubility of 5-allyl-5-(2-hydroxypropyl)-1-phenyl-hexahydropyrimidine-2,4,6-trione

The solubility of 5-allyl-5-(2-hydroxypropyl)-1-phenyl-hexahydropyrimidine-2,4,6-trione can be evaluated based on its structural features and functional groups. Several key factors influence the solubility of this compound:

  • Polarity: The presence of the hydroxyl group (-OH) suggests that the compound may exhibit some degree of polarity, which often correlates with solubility in polar solvents like water.
  • Hydrophobic Regions: The phenyl and allyl groups introduce hydrophobic characteristics, potentially diminishing overall solubility in polar solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds due to the hydroxyl group can enhance solubility in polar solvents, yet the hydrophobicity of other parts might counterbalance this effect.

In summary, solubility is expected to be moderate due to the combination of hydrophilic and hydrophobic components. It is essential to consider the specific solvent conditions to make more definitive assessments. Testing in various solvents may reveal interesting insights into its solubility behavior.

Interesting facts

Interesting Facts About 5-Allyl-5-(2-hydroxypropyl)-1-phenyl-hexahydropyrimidine-2,4,6-trione

This compound, 5-allyl-5-(2-hydroxypropyl)-1-phenyl-hexahydropyrimidine-2,4,6-trione, belongs to a fascinating class of organic compounds known as pyrimidines. These compounds are integral in various biochemical processes, particularly in the fields of genetics and molecular biology.

Key Features:

  • Diverse Applications: Pyrimidines and their derivatives are often utilized in pharmaceuticals, agricultural chemicals, and as essential building blocks in nucleic acids.
  • Structural Complexity: The presence of multiple functional groups in this compound, such as the allyl and hydroxypropyl groups, adds to its reactivity and versatility, making it a potential candidate for various synthetic pathways.
  • Research Potential: Compounds like this one are under investigation for their biological activities, including anti-inflammatory and anticancer properties.

Interestingly, the hexahydropyrimidine ring structure is noteworthy for its stability and can easily partake in reactions that modify its properties. As remarked by researchers, "Understanding the reactivity of such compounds can lead to innovative solutions in medicinal formulations."

Its chiral centers offer a realm of opportunities for stereochemistry studies, making it a captivating subject for students and scientists alike who are delving into asymmetric synthesis.

Conclusion:

In summary, 5-allyl-5-(2-hydroxypropyl)-1-phenyl-hexahydropyrimidine-2,4,6-trione exemplifies the intricate beauty of organic chemistry. Its complex structure and potential biological activities highlight the importance of pyrimidines in both research and industry. As the exploration of such compounds continues, it is clear that they hold significant promise for future advancements in chemical science.

Synonyms
14305-83-0
5-Allyl-5-(beta-hydroxypropyl)-N-phenylbarbituric acid
5-allyl-(beta-hydroxy)propyl-N-phenylbarbituric acid
BRN 0759146
5-Allyl-5-(2-hydroxypropyl)-1-phenyl-barbituric acid
5-Allyl-5-(beta-hydroxy)propyl-N-phenylbarbituric acid
5-Allil-(beta-idrossi)propil-N-fentilbariturico [Italian]
5-Allilo-5-(beta-hydroksypropylo)-N-fenylobarbiturowy [Polish]
5-Allil-(beta-idrossi)propil-N-fentilbariturico
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(2-hydroxypropyl)-1-phenyl-5-(2-propenyl)-
5-25-03-00295 (Beilstein Handbook Reference)
5-Allilo-5-(beta-hydroksypropylo)-N-fenylobarbiturowy
DTXSID30931732
BARBITURIC ACID, 5-ALLYL-5-(2-HYDROXYPROPYL)-1-PHENYL-
5-(2-hydroxypropyl)-1-phenyl-5-prop-2-enyl-1,3-diazinane-2,4,6-trione
6-Hydroxy-5-(2-hydroxypropyl)-3-phenyl-5-(prop-2-en-1-yl)pyrimidine-2,4(3H,5H)-dione