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Primidone

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Identification
Molecular formula
C12H14N2O2
CAS number
125-33-7
IUPAC name
5-allyl-5-(2-hydroxypropyl)hexahydropyrimidine-2,4,6-trione
State
State

At room temperature, Primidone is in a solid state.

Melting point (Celsius)
279.00
Melting point (Kelvin)
552.15
Boiling point (Celsius)
401.00
Boiling point (Kelvin)
674.15
General information
Molecular weight
218.25g/mol
Molar mass
218.2540g/mol
Density
1.3230g/cm3
Appearence

Primidone appears as a white crystalline powder. It is tasteless and odorless.

Comment on solubility

Solubility Characteristics of 5-allyl-5-(2-hydroxypropyl)hexahydropyrimidine-2,4,6-trione

The solubility of 5-allyl-5-(2-hydroxypropyl)hexahydropyrimidine-2,4,6-trione can be influenced by various factors, including its structural features and the presence of functional groups.

  • Polar vs Non-polar: The introduction of the hydroxypropyl group contributes to polar interactions, suggesting that this compound may exhibit moderate solubility in polar solvents such as water.
  • Solvent Compatibility: It is likely to have increased solubility in alcohols and other protic solvents due to the potential for hydrogen bonding.
  • Effects of Concentration: At higher concentrations, the solubility can be affected by intermolecular interactions, which might lead to precipitation or reduced solubility.

In summary, while the exact solubility value may require empirical data, the compound's polar character implies it is expected to be soluble in a range of solvents, particularly those able to interact favorably through hydrogen bonding. Further studies are recommended to accurately characterize its solubility profile across various environments.

Interesting facts

Interesting Facts about 5-Allyl-5-(2-hydroxypropyl)hexahydropyrimidine-2,4,6-trione

5-Allyl-5-(2-hydroxypropyl)hexahydropyrimidine-2,4,6-trione is a fascinating compound that belongs to the class of pyrimidine derivatives, which are known for their significance in various biological processes. Here are some noteworthy points about this intriguing compound:

  • Versatile Applications: This compound plays a pivotal role in organic synthesis, particularly in the development of pharmacologically active molecules owing to its pyrimidine framework.
  • Biological Importance: Many pyrimidine derivatives are essential building blocks for nucleic acids, which carry genetic information. This positions 5-allyl-5-(2-hydroxypropyl)hexahydropyrimidine-2,4,6-trione as a valuable structure in research related to genetics and molecular biology.
  • Functional Groups: The presence of both allyl and hydroxypropyl groups bestows unique reactivity characteristics, potentially allowing for further derivatization and the creation of more complex molecules.
  • Chemical Behavior: This compound may exhibit interesting tautomeric forms, which can influence its chemical reactivity and interactions with other species.
  • Research Potential: Ongoing studies could unveil novel therapeutic potentials, particularly in treating diseases related to nucleic acid function or metabolism.

In summary, 5-allyl-5-(2-hydroxypropyl)hexahydropyrimidine-2,4,6-trione serves as a prime example of how relatively simple chemical structures can open doors to greater understanding and groundbreaking advancements in both chemistry and biology. With its unique properties, it's a compound that undoubtedly deserves more investigation.

Synonyms
Proxibarbal
Centralgol
Hydroxydial
Ipronal
Axeen
2537-29-3
Centralgyl
Proxibarbal [INN]
Proxibarbalum
Proxibarbalum [INN-Latin]
Centralgol (TN)
EINECS 219-803-4
HH 184
Proxibarbal (INN)
F97OMS297F
5-Allyl-5-(beta-hydroxypropyl)malonylurea
5-Allyl-5-(2-hydroxypropyl)barbituric acid
BARBITURIC ACID, 5-ALLYL-5-(2-HYDROXYPROPYL)-
PROXIBARBAL [MI]
HH-184
PROXIBARBAL [MART.]
PROXIBARBAL [WHO-DD]
5-Allilo-5-(beta-hydroksypropylo)-barbiturowy [Polish]
Kwas 5-allilo-5-(beta-hydroksy-propylo)barbiturowy [Polish]
5-Allilo-5-(beta-hydroksypropylo)-barbiturowy
5-(2-Hydroxypropyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Kwas 5-allilo-5-(beta-hydroksy-propylo)barbiturowy
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(2-hydroxypropyl)-5-(2-propenyl)-
Proxibarbalum (INN-Latin)
PROXIBARBAL (MART.)
2,4,6(1H,3H,5H)-PYRIMIDINETRIONE, 5-(2-HYDROXYPROPYL)-5-(2-PROPEN-1-YL)-
proxybarbital
N05CA22
5-(2-hydroxypropyl)-5-(prop-2-en-1-yl)-1,3-diazinane-2,4,6-trione
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(2-hydroxypropyl)-5-(2-propenyl)-(9CI)
219-803-4
Proxibarbital
Proxibarbal, (+)-
Proxibarbal, (-)-
BRN 0219840
RE966VDY2Y
Y54BSX54CS
5-(2-hydroxypropyl)-5-prop-2-enyl-1,3-diazinane-2,4,6-trione
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(2-hydroxypropyl)-5-(2-propenyl)-, (+)-
42013-22-9
Barbituric acid, 5-(2-propenyl)-5-(2-hydroxypropyl)
Ipronal, (+-)-
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(2-hydroxypropyl)-5-(2-propen-1-yl)-, (+)-
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(2-hydroxypropyl)-5-(2-propenyl)- (9CI)
42013-23-0
UNII-F97OMS297F
dl-5-Allyl-5-(2-hydroxypropyl)barbituric acid
l-5-Allyl-5-(2-hydroxypropyl)barbituric acid
l-5-Allyl-5-(beta-hydroxypropyl)barbituric acid
dl-5-Allyl-5-(beta-hydroxypropyl)barbituric acid
Barbituric acid, 5-allyl-5-(2-hydroxypropyl)-, (-)-
BARBITURIC ACID, 5-ALLYL-5-(2-HYDROXYPROPYL)-, (+-)-
UNII-RE966VDY2Y
UNII-Y54BSX54CS
(+/-)-IPRONAL
SCHEMBL715014
CHEMBL2105233
DTXSID20862980
CHEBI:134928
AKOS040753638
CS-6617
DB13253
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(2-hydroxypropyl)-5-(2-propenyl)-, (+-)-
42013-34-3
HY-101635
NS00046516
5-allyl-5-(2-hydroxypropyl)-barbituric acid
D07324
D-5-allyl-5-(beta-hydroxypropyl)barbituric acid
Q906452
D-5-ALLYL-5-(.BETA.-HYDROXYPROPYL)BARBITURIC ACID
L-5-ALLYL-5-(.BETA.-HYDROXYPROPYL)BARBITURIC ACID
2,4,6(1H,3H,5H)-PYRIMIDINETRIONE, 5-(2-HYDROXYPROPYL)-5-(2-PROPENYL)-, (-)-
2,4,6(1H,3H,5H)-PYRIMIDINETRIONE, 5-(2-HYDROXYPROPYL)-5-(2-PROPEN-1-YL)-, (-)-