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5-Amino-2-(1,3,4-oxadiazol-2-yl)phenol

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Identification
Molecular formula
C8H7N3O2
CAS number
148992-58-9
IUPAC name
5-amino-2-(1,3,4-oxadiazol-2-yl)phenol
State
State

At room temperature, 5-amino-2-(1,3,4-oxadiazol-2-yl)phenol is a solid compound. It is typically handled in its solid form, as it is not volatile and remains stable under standard environmental conditions.

Melting point (Celsius)
178.00
Melting point (Kelvin)
451.15
Boiling point (Celsius)
375.00
Boiling point (Kelvin)
648.15
General information
Molecular weight
177.16g/mol
Molar mass
177.1610g/mol
Density
1.4000g/cm3
Appearence

5-Amino-2-(1,3,4-oxadiazol-2-yl)phenol typically appears as a crystalline solid with a white to light beige color. The crystallinity and color can vary slightly based on the degree of purity and the specific conditions under which the compound was synthesized.

Comment on solubility

Solubility of 5-amino-2-(1,3,4-oxadiazol-2-yl)phenol

The solubility characteristics of 5-amino-2-(1,3,4-oxadiazol-2-yl)phenol are influenced by its molecular structure, which contains both hydrophilic and hydrophobic segments. This compound can exhibit a range of solubility behaviors based on the solvent used and the conditions applied.

Key Points on Solubility:

  • Polar Solvents: Generally, compounds with amino groups and heterocycles tend to be more soluble in polar solvents like water and methanol due to the ability to form hydrogen bonds.
  • Nonpolar Solvents: In contrast, 5-amino-2-(1,3,4-oxadiazol-2-yl)phenol may have limited solubility in nonpolar solvents due to its polar functional groups.
  • pH Dependence: The solubility may also vary with pH; for example, increased acidity can protonate the amino group, potentially enhancing solubility in aqueous solutions.
  • Temperature Effects: As with many compounds, solubility may increase with temperature, making it a variable factor in solvent selection.

In summary, the solubility of 5-amino-2-(1,3,4-oxadiazol-2-yl)phenol can be moderated by various factors including solvent type, temperature, and pH, making it essential to consider these elements when investigating its applications in scientific research or industrial processes.

Interesting facts

Interesting Facts about 5-amino-2-(1,3,4-oxadiazol-2-yl)phenol

5-amino-2-(1,3,4-oxadiazol-2-yl)phenol is a fascinating compound with a rich background in both medicinal and agricultural chemistry. This compound belongs to the class of oxadiazoles, known for their diverse applications and significant biological activities. Here are some compelling aspects of this compound:

  • Pharmaceutical Potential: The presence of the amino group and the oxadiazole ring in the molecular structure contributes to its potential as a drug design candidate. Compounds with similar structures have been studied for their antibacterial, antifungal, and antitumor activities.
  • Versatile Applications: Beyond medicinal chemistry, this compound is also explored for its use in agrochemicals. The ability to modify its structure allows for the development of herbicides and pesticides with enhanced efficacy.
  • Research Interest: Researchers are continually investigating the properties of oxadiazoles due to their unique electronic configurations, which can lead to interesting photochemical properties. This exploration opens avenues for applications in materials science, such as organic semiconductors.
  • Structure-Activity Relationship (SAR): The study of this compound contributes to the understanding of how structural modifications can influence biological activity. This is crucial in the field of medicinal chemistry for optimizing lead compounds into more effective drugs.
  • Biochemical Interactions: Early studies suggest this compound might interact with specific enzymes or receptors, making it a point of interest for biochemical research. These interactions could provide insight into mechanisms of action and help guide future synthesis.

In summary, 5-amino-2-(1,3,4-oxadiazol-2-yl)phenol represents a remarkable intersection of chemistry, biology, and technology, showcasing the continuous efforts of scientists to harness the power of small molecules for the betterment of health and agriculture.