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Neomycin

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Identification
Molecular formula
C23H46N6O13
CAS number
119-04-0
IUPAC name
5-amino-2-(aminomethyl)-6-[4,6-diamino-2-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]oxy-3-hydroxy-cyclohexoxy]tetrahydropyran-3,4-diol
State
State

Neomycin is typically found as a solid under normal conditions of temperature and pressure. Being a stable hygroscopic compound, it requires appropriate storage conditions to maintain its solid state without absorbing moisture from the environment.

Melting point (Celsius)
199.00
Melting point (Kelvin)
472.15
Boiling point (Celsius)
320.00
Boiling point (Kelvin)
593.15
General information
Molecular weight
614.64g/mol
Molar mass
614.6410g/mol
Density
1.6600g/cm3
Appearence

Neomycin typically appears as a white to off-white powder. It is generally hygroscopic, absorbing moisture from the air. Being a hygroscopic solid, it's essential to store it in a tightly closed container to maintain its integrity and efficacy.

Comment on solubility

Solubility of 5-amino-2-(aminomethyl)-6-[4,6-diamino-2-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]oxy-3-hydroxy-cyclohexoxy]tetrahydropyran-3,4-diol (C23H46N6O13)

The solubility characteristics of 5-amino-2-(aminomethyl)-6-[4,6-diamino-2-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]oxy-3-hydroxy-cyclohexoxy]tetrahydropyran-3,4-diol can be quite complex due to its extensive molecular structure and multiple functional groups. Key insights into its solubility are as follows:

  • Hydrophilicity: The presence of multiple hydroxyl (-OH) groups generally suggests a strong potential for water solubility, as these groups can form hydrogen bonds with water molecules.
  • Amine Groups: The amine (-NH2) functionalities present may further enhance solubility in polar solvents, contributing to its ability to interact favorably with water.
  • Solvation Effects: The size and steric hindrance from the bulky tetrahydropyran and cyclohexane moieties could somewhat hinder solubility in more apolar solvents or even limit the solubility in water under certain conditions.
  • Concentration Variability: Solubility may vary significantly with concentration, temperature, and pH, affecting the interactions between this compound and potential solvents.

In summary, while the numerous hydroxyl and amine groups indicate that 5-amino-2-(aminomethyl)-6-[4,6-diamino-2-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]oxy-3-hydroxy-cyclohexoxy]tetrahydropyran-3,4-diol is likely to be soluble in polar solvents, factors such as molecular size and steric hindrance must also be considered for an accurate understanding of its solubility behavior.

Interesting facts

Interesting Facts about 5-Amino-2-(aminomethyl)-6-[4,6-diamino-2-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]oxy-3-hydroxy-cyclohexoxy]tetrahydropyran-3,4-diol

This compound exhibits a complex structure that underscores the fascinating world of organic chemistry. Here are some intriguing aspects of this molecule:

  • Biological Significance: Compounds similar to this one are often involved in various biological processes, making them relevant in pharmaceutical research. Their structures can mimic natural products, leading to potential therapeutic uses.
  • Structural Complexity: The elaborate structure features multiple functional groups, including amino groups and hydroxyl groups. This complexity allows for interactions with various biological targets, which could be explored for potential drug development.
  • Potential Applications: Given its multifaceted structure, this compound may have applications in antimicrobial and antiviral drug formulations. Research into similar compounds has shown promising results in combating resistant pathogens.
  • Inspirations from Nature: The presence of sugar-like structures in its composition is reminiscent of natural products, suggesting a possible natural origin or inspiration for synthesis.
  • Synthetic Challenges: The synthesis of such a complex molecule can be quite challenging, often requiring multi-step reactions and advanced techniques in organic synthesis to construct the necessary functional groups in the correct stereochemistry.

In summary, the study of 5-amino-2-(aminomethyl)-6-[4,6-diamino-2-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]oxy-3-hydroxy-cyclohexoxy]tetrahydropyran-3,4-diol is essential in advancing our understanding of complex organic compounds and their potential in medicinal chemistry.

Synonyms
Xylostasin
50474-67-4
5-amino-2-(aminomethyl)-6-[4,6-diamino-2-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol
NSC236658
Ribostamycin sulfate salt
4,6-diamino-3-hydroxy-2-(pentofuranosyloxy)cyclohexyl 2,6-diamino-2,6-dideoxyhexopyranoside
CHEMBL300914
SCHEMBL4318426
SCHEMBL19944115
DTXSID80860346
CCG-102472
NSC-236658
Q3934263
BRD-A86073102-001-01-6
D-Streptamine,6-diamino-2,6-dideoxy-.alpha.-D-glucopyranosyl-(1.fwdarw.4)-O-[.beta.-D-ribofuranosyl-(1.fwdarw.5)]-2-deoxy-
O-2,6-dideoxy-.alpha.-D-glucopyranosyl-(1.fwdarw.4)-O-[.beta.-D-ribofuranosyl-(1.fwdarw.5)]-2-deoxystreptamine