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Kanamycin

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Identification
Molecular formula
C18H36N4O11
CAS number
70560-43-5
IUPAC name
5-amino-2-(aminomethyl)-6-[4,6-diamino-3-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]tetrahydropyran-3,4-diol
State
State

At room temperature, Kanamycin typically exists as a solid. It is usually encountered as a powder, often used in its sulfate form, which is more stable for storage and use in pharmaceutical preparations.

Melting point (Celsius)
290.00
Melting point (Kelvin)
563.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
484.52g/mol
Molar mass
484.4700g/mol
Density
1.5000g/cm3
Appearence

The compound appears as a white to off-white powder. It is typically supplied as a sulfate salt, and the appearance can vary slightly based on the form and level of hydration.

Comment on solubility

Solubility of 5-amino-2-(aminomethyl)-6-[4,6-diamino-3-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]tetrahydropyran-3,4-diol

The solubility of the compound with the formula C18H36N4O11 is influenced by its complex molecular structure, which features multiple functional groups that are hydrophilic in nature. Here are a few key points about its solubility:

  • Hydrophilic Groups: The presence of amino (–NH2) and hydroxyl (–OH) groups often leads to increased solubility in polar solvents, particularly water.
  • Hybrid Structure: The combination of hydrophobic segments alongside hydrophilic regions can result in varied solubility profiles depending on the solvent used.
  • pH Sensitivity: The solubility may also vary significantly with changes in pH. In acidic or basic environments, the ionization of the amino and hydroxyl groups can enhance solubility.
  • Solvent Dependency: While it is likely soluble in water due to its numerous polar functional groups, the solubility in organic solvents may be limited and is often less predictable.

In summary, the solubility of this compound is a delicate balance influenced by its functional groups and the environmental conditions. Testing in various solvents can provide a more comprehensive understanding of its solubility behavior, making it a fascinating subject for further investigation.

Interesting facts

Interesting Facts about 5-Amino-2-(aminomethyl)-6-[4,6-diamino-3-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]tetrahydropyran-3,4-diol

This intriguing compound, known for its complex structure and numerous functional groups, is primarily associated with medicinal chemistry and the field of pharmaceutical research. Here are some key facts that make it particularly fascinating:

  • Structural Complexity: The compound boasts a highly intricate molecular architecture involving multiple amino and hydroxyl groups, which play a vital role in its biological activity.
  • Potential Bioactivity: Compounds with similar structures are often studied for their potential as antibiotics or antimetabolites. This suggests possibilities in developing new treatments for various diseases.
  • Mechanism of Action: The presence of functional groups such as amino and hydroxyl may contribute to its ability to interact with biological targets, making it a subject of interest in enzyme inhibition studies.
  • Synthetic Pathways: The methods of synthesizing this compound can involve multiple steps, often utilizing reagents that control stereochemistry, reflecting the precision required in modern synthetic organic chemistry.
  • Research Applications: Scientists frequently explore this compound for its role in understanding metabolic pathways, providing insight into how drug modifications can lead to improved efficacy and reduced side effects.
  • Historical Context: Similar compounds have been used historically in traditional medicine, showcasing the invaluable contributions of natural products to contemporary pharmaceuticals.

The study of 5-amino-2-(aminomethyl)-6-[4,6-diamino-3-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]tetrahydropyran-3,4-diol not only highlights its individual characteristics but also serves as a reminder of the complexity and richness of chemical compounds that continue to influence many areas of science.

Synonyms
becanamycin
4,6-diamino-3-[(3-amino-3-deoxyhexopyranosyl)oxy]-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxyhexopyranoside
DivK1c_000907
SCHEMBL13018550
HMS502N09
KBio1_000907
DTXSID70859885
NINDS_000907
IDI1_000907
SW222250-1