Acrivastine | Solubility of Things

Identification

Molecular formula

C₂₂H₂₄N₄O₃

CAS number

70930-50-6

IUPAC name

5-amino-4-(2-hydroxy-3,4-dimethoxy-phenyl)-6-(4-methoxy-2,2-dimethyl-5-oxo-4H-imidazo[4,5-h]quinolin-8-yl)-3-methyl-pyridine-2-carboxylic acid

State

At room temperature, acrivastine is a solid compound. It usually comes in the form of a powder, which makes it easy to handle for pharmaceutical formulations and research applications.

Melting point (Celsius)

190.00

Melting point (Kelvin)

463.15

Boiling point (Celsius)

274.00

Boiling point (Kelvin)

547.15

General information

Molecular weight

387.46g/mol

Molar mass

387.4290g/mol

Density

1.3000g/cm³

Appearence

Acrivastine typically appears as a white to off-white powder. It is odorless and has a bitter taste. The powder may vary slightly in shade but is generally uniform in appearance under standard laboratory conditions.

Comment on solubility

Solubility Characteristics

The solubility of 5-amino-4-(2-hydroxy-3,4-dimethoxy-phenyl)-6-(4-methoxy-2,2-dimethyl-5-oxo-4H-imidazo[4,5-h]quinolin-8-yl)-3-methyl-pyridine-2-carboxylic acid can be influenced by various factors. Here are key points to consider:

Polarity: Due to its multiple functional groups, such as hydroxyl and amino groups, this compound exhibits both polar and non-polar characteristics, which may enhance its ability to dissolve in a variety of solvents.
Solvent Type: The solubility may be greater in polar solvents (e.g., water, ethanol) compared to non-polar solvents (e.g., hexane, toluene).
pH Dependence: The solubility can be significantly affected by the pH of the solution due to the presence of a carboxylic acid group, which may ionize and increase solubility in basic environments.
Temperature Influence: As with many organic compounds, increasing the temperature typically enhances solubility, allowing for greater interaction between the solute and solvent.

Furthermore, it is worth noting that the solubility data for such complex molecules may vary based on specific conditions and the presence of other solutes. Always consult detailed solubility charts or empirical data for precise values under varying conditions.

Interesting facts

Interesting Facts about 5-Amino-4-(2-hydroxy-3,4-dimethoxy-phenyl)-6-(4-methoxy-2,2-dimethyl-5-oxo-4H-imidazo[4,5-h]quinolin-8-yl)-3-methyl-pyridine-2-carboxylic acid

This intriguing compound is distinguished by its complexity and unique structural features that contribute to its potential applications in various fields, particularly in medicinal chemistry. Here are some remarkable aspects of this compound:

Multi-Functional Groups: The presence of amino, carboxylic acid, and methoxy groups enhances its ability to interact with biological systems, making it a candidate for drug development.
Bioactive Potential: Compounds featuring imidazoquinoline scaffolds have shown various pharmacological activities, including anti-cancer, anti-microbial, and anti-inflammatory properties.
Bioavailability: The modifications in the aromatic rings may improve the compound's bioavailability, making it more effective as a therapeutic agent.
Synthesis Interest: The synthetic routes to create such a complex molecule can be seen as a challenge and an opportunity to innovate in organic synthesis methodologies.
Structure-Activity Relationship (SAR): Understanding the relationship between the molecular structure and its biological activity offers insights that can help in the rational design of more potent derivatives.

As the scientific community continues to unravel the potential properties of such compounds, the study of 5-amino-4-(2-hydroxy-3,4-dimethoxy-phenyl)-6-(4-methoxy-2,2-dimethyl-5-oxo-4H-imidazo[4,5-h]quinolin-8-yl)-3-methyl-pyridine-2-carboxylic acid exemplifies the intersection of chemical complexity and biological significance. Its unique formulation aims to encourage future exploration in the quest for novel therapeutic solutions.