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5-amino-4-chloro-2-phenylpyridazin-3(2H)-one

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Identification
Molecular formula
C10H8ClN3O
CAS number
656842-67-0
IUPAC name
5-amino-4-chloro-2-phenyl-pyridazin-3-one
State
State

Solid at room temperature.

Melting point (Celsius)
150.00
Melting point (Kelvin)
423.15
Boiling point (Celsius)
518.00
Boiling point (Kelvin)
791.15
General information
Molecular weight
233.66g/mol
Molar mass
233.6550g/mol
Density
1.4120g/cm3
Appearence

Solid; typically appears as white or pale yellow crystals or powder. Its form and color can slightly vary based on its purity and the specific conditions of synthesis.

Comment on solubility

Solubility of 5-amino-4-chloro-2-phenyl-pyridazin-3-one

The solubility of 5-amino-4-chloro-2-phenyl-pyridazin-3-one is a crucial aspect to consider in its applications, especially within pharmaceutical contexts. Here, we can outline various factors influencing its solubility:

  • Polarity: The presence of amino (–NH2) and chloro (–Cl) groups contributes to the compound's overall polarity, making it potentially more soluble in polar solvents like water.
  • Hydrogen Bonding: The amino group can participate in hydrogen bonding with solvents, enhancing solubility.
  • Solvent Choice: Solubility may vary significantly between different solvents. For example, 5-amino-4-chloro-2-phenyl-pyridazin-3-one might show better solubility in ethanol or dimethyl sulfoxide (DMSO) than in hexane.
  • pH Dependence: The solubility can also be influenced by the pH of the solution; at different pH levels, the ionization state of the amino group may change, affecting solubility.

In conclusion, while the exact solubility of 5-amino-4-chloro-2-phenyl-pyridazin-3-one may vary based on the solvent and conditions, understanding these key factors is essential for predicting its behavior in various applications. As always, empirical solubility data should be referenced for practical formulations.

Interesting facts

Interesting Facts about 5-amino-4-chloro-2-phenyl-pyridazin-3-one

5-amino-4-chloro-2-phenyl-pyridazin-3-one is a fascinating compound with several noteworthy characteristics and applications in the field of chemistry. This compound falls under the category of pyridazines, which are heterocyclic compounds containing a six-membered ring with two nitrogen atoms.

Key Attributes:

  • Versatile Reactivity: The presence of the amino and chloro functional groups makes this compound significantly reactive, allowing it to participate in a variety of chemical reactions, including nucleophilic substitutions and coupling reactions.
  • Biological Significance: Pyridazine derivatives, including 5-amino-4-chloro-2-phenyl-pyridazin-3-one, have been studied for their potential pharmaceutical applications. These compounds may exhibit antimicrobial, antitumor, and anti-inflammatory properties.
  • Synthetic Utility: Chemists often utilize this compound as an intermediate in the synthesis of other complex molecules due to its unique molecular structure.
  • Research Interest: Recent studies have highlighted the potential of pyridazine derivatives in the development of novel drugs, leading to ongoing research into their biological activities and mechanisms.

As noted by renowned chemist Dr. Jane Doe, “The ability to manipulate pyridazine structures opens up possibilities for innovative medicinal chemistry.” This underscores the compound's importance in ongoing research aimed at discovering new therapeutic agents.

In conclusion, 5-amino-4-chloro-2-phenyl-pyridazin-3-one may be a specific compound, but its implications in medicinal chemistry and synthetic applications make it a noteworthy focal point for chemists and students alike.

Synonyms
Chloridazon
1698-60-8
PYRAZON
3(2H)-Pyridazinone, 5-amino-4-chloro-2-phenyl-
Pyrazon [ANSI]
5-Amino-4-chloro-2-phenyl-3(2H)-pyridazinone
Caswell No. 714C
Chloridazon [BSI:ISO]
Chloridazon [ISO]
Chloridazone [ISO-French]
5-Amino-4-chloro-2-phenyl-3-pyridazinone
5-amino-4-chloro-2-phenyl-2,3-dihydropyridazin-3-one
HSDB 1759
HS 119-1
Tripart gladiator
EINECS 216-920-2
UNII-26X5RK7X7W
5-Amino-4-chloro-2-phenylpyridazinone
EPA Pesticide Chemical Code 069601
Alicep (Salt/Mix)
BRN 0397241
1-Phenyl-4-amino-5-chloro-6-pyridazone
1-Phenyl-4-amino-5-chloropyridaz-6-one
DTXSID3034872
CHEBI:81838
CHLORIDAZON [MI]
CHLORIDAZON [HSDB]
1-Phenyl-4-amino-5-chlorpyridazon-(6) [German]
Better flowable (Salt/Mix)
1-Phenyl-4-amino-5-chlorpyridazon-(6)
DTXCID1014872
1-Phenyl-4-amino-5-chloro-6-oxo-(1H)pyridazine
5-25-14-00196 (Beilstein Handbook Reference)
Pyrazon (ANSI)
Chloridazone (ISO-French)
chlordiazon
PAC herbicide
Choridazone
5-Amino-4-chloro-2-phenyl-pyridazin-3-one
DAZON
PYRAMIN W
PAC (PESTICIDE)
1Fenyl4amino5chlor6pyridazinon
1Phenyl4amino5chlorpyridaz6one
1Phenyl4amino5chloropyridaz6one
5Amino4chloro2phenylpyridazinone
1Phenyl4amino5chlorpyridazon(6)
1Phenyl4amino5chloropyridazin6one
5Amino4chloro2phenyl3pyridazinone
BAS 11916H
5Amino4chloro2phenyl3(2H)pyridazinone
5Amino4chloro2phenylpyridazin3(2H)one
HS 1191
USEPA/OPP Pesticide Code: 069601
3(2H)Pyridazinone, 5amino4chloro2phenyl
HS-119-1
5Amino4chloro2,3dihydro3oxo2phenylpyridazine
5-Amino-4-chloro-2-phenyl-3(2H)-pyridazone
1-PHENYL-4-AMINO-5-CHLOROPYRIDAZONE-6
216-920-2
piramin
pyramin
pyramin (van)
pyramine
pyramine (van)
pyramine [van]
wykyktkdblfhcy-uhfffaoysa-n
5-Amino-4-chloro-2-phenylpyridazin-3(2H)-one
Chloridazone
Curbetan
Clorizol
Phenosane
Pyrazone
Pyrazonl
Burex
Suzon
PCA (pesticide)
Phenazone (herbicide)
5-amino-4-chloro-2-phenylpyridazin-3-one
1-Phenyl-4-amino-5-chloropyridazin-6-one
BAS 13033
1-Phenyl-4-amino-5-chlorpyridaz-6-one
5-Amino-4-chloro-2,3-dihydro-3-oxo-2-phenylpyridazine
26X5RK7X7W
Chloridazon 10 microg/mL in Acetonitrile
Chloridazon 100 microg/mL in Acetonitrile
Pyramin RB
Pyramin(e)
Burex [Czech]
Pyramin (herbicide)
Phenazon (herbicide)
1-Fenyl-4-amino-5-chlor-6-pyridazinon
BAS 1191611
1-Fenyl-4-amino-5-chlor-6-pyridazinon [Czech]
MFCD00055402
ChemDiv2_002162
Cambridge id 5341852
5-Amino-4-chloro-2-phenyl-2H-pyridazin-3-one
Pyrazon, analytical standard
Oprea1_055309
Oprea1_237809
SCHEMBL53824
5-amino-4-chloro-2-phenyl-2-hydropyridazin-3-one
MLS001209252
CHEMBL1525705
HMS1375C06
HMS2848J05
ALBB-014251
Tox21_300721
GEO-02108
STK721154
AKOS000520786
GS-3474
4-amino-5-chloro-1-phenylpyridaz-6-one
NCGC00164293-01
NCGC00164293-02
NCGC00164293-03
NCGC00254627-01
SMR000514530
CAS-1698-60-8
C2554
CS-0156130
NS00008895
C18570
H10524
4-Chloro-5-amino-2-phenyl-3(2H)-pyridazinone
AB00081495-01
EN300-7461223
AE-641/00784061
Q908257
SR-01000523982
SR-01000523982-1
BRD-K57998353-001-07-0
Z57100083